KEGG   ORTHOLOGY: K05450Help
Entry
K05450                      KO                                     

Name
PDGFC_D
Definition
platelet derived growth factor C/D
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04540  Gap junction
ko04810  Regulation of actin cytoskeleton
ko05215  Prostate cancer
ko05218  Melanoma
ko05231  Choline metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04015 Rap1 signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04010 MAPK signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04072 Phospholipase D signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
   04151 PI3K-Akt signaling pathway
    K05450  PDGFC_D; platelet derived growth factor C/D
  Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05450  PDGFC_D; platelet derived growth factor C/D
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05450  PDGFC_D; platelet derived growth factor C/D
   04540 Gap junction
    K05450  PDGFC_D; platelet derived growth factor C/D
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05450  PDGFC_D; platelet derived growth factor C/D
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
   05218 Melanoma
    K05450  PDGFC_D; platelet derived growth factor C/D
   05215 Prostate cancer
    K05450  PDGFC_D; platelet derived growth factor C/D
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K05450  PDGFC_D; platelet derived growth factor C/D
Cytokines and growth factors [BR:ko04052]
 Growth factors
  Growth factors (RTK binding)
   K05450  PDGFC_D; platelet derived growth factor C/D
BRITE hierarchy
Other DBs
GO: 0005161
Genes
HSA: 56034(PDGFC) 80310(PDGFD)
PTR: 466765(PDGFD) 736477(PDGFC)
PPS: 100982459(PDGFC) 100992738(PDGFD)
GGO: 101134877(PDGFD) 101144807(PDGFC)
PON: 100172718(PDGFD) 100437861(PDGFC)
NLE: 100585549(PDGFC) 100586178(PDGFD)
MCC: 700236(PDGFC) 704310(PDGFD)
MCF: 101925936(PDGFD) 102132043(PDGFC)
CSAB: 103236438(PDGFC) 103248362(PDGFD)
RRO: 104655283(PDGFD) 104658109(PDGFC)
RBB: 108529019(PDGFC) 108534757(PDGFD)
CJC: 100393010(PDGFC) 100398033(PDGFD)
SBQ: 101038849(PDGFC) 101049234(PDGFD)
MMU: 54635(Pdgfc) 71785(Pdgfd)
RNO: 66018(Pdgfd) 79429(Pdgfc)
CGE: 100756952(Pdgfd) 100765334(Pdgfc)
NGI: 103731702(Pdgfd) 103751038(Pdgfc)
HGL: 101696768(Pdgfd) 101710927(Pdgfc)
CCAN: 109701575(Pdgfc) 109702404(Pdgfd)
OCU: 100008912(PDGFD) 100350272(PDGFC)
TUP: 102485007(PDGFD) 102487522(PDGFC)
CFA: 479460(PDGFD) 482666(PDGFC)
AML: 100479872(PDGFD) 100481171(PDGFC)
UMR: 103658054(PDGFC) 103662543(PDGFD)
ORO: 101363701(PDGFD) 101378889(PDGFC)
FCA: 101084984(PDGFD) 101088742(PDGFC)
PTG: 102949957(PDGFD) 102970530(PDGFC)
AJU: 106974876(PDGFC) 106976474(PDGFD)
BTA: 525931(PDGFD) 613787(PDGFC)
BOM: 102273267(PDGFD) 102274384(PDGFC)
BIU: 109569805(PDGFD) 109571395(PDGFC)
PHD: 102331529(PDGFC) 102341549(PDGFD)
CHX: 102168651(PDGFD) 102168934(PDGFC)
OAS: 101112600(PDGFC) 101117784(PDGFD)
SSC: 100515267(PDGFC) 100524161(PDGFD)
CFR: 102508964(PDGFC) 102515439(PDGFD)
CDK: 105101177(PDGFC) 105103704(PDGFD)
BACU: 103015925(PDGFD) 103019677(PDGFC)
LVE: 103076387(PDGFC) 103085046(PDGFD)
OOR: 101278539(PDGFC) 101290342(PDGFD)
ECB: 100061488(PDGFD) 100062015(PDGFC)
EPZ: 103547315(PDGFC) 103558709(PDGFD)
EAI: 106833032(PDGFC) 106843123(PDGFD)
MYB: 102240259(PDGFD) 102248385(PDGFC)
MYD: 102766117(PDGFC) 102772727(PDGFD)
HAI: 109372936(PDGFC) 109394938(PDGFD)
RSS: 109437504(PDGFD) 109448190(PDGFC)
PALE: 102890668(PDGFC) 102894123(PDGFD)
LAV: 100661451(PDGFD) 100672750(PDGFC)
MDO: 100011261(PDGFD) 100023701(PDGFC)
SHR: 100916102(PDGFD) 100928148(PDGFC)
OAA: 100078558(PDGFD) 100079757(PDGFC)
GGA: 395469(PDGFC) 418978(PDGFD)
MGP: 100543088(PDGFD) 100547981(PDGFC) 104917613
CJO: 107308377(PDGFD) 107313060(PDGFC)
APLA: 101789650(PDGFC) 101798843(PDGFD)
ACYG: 106032364(PDGFC) 106034125(PDGFD)
TGU: 100217775(PDGFC) 100221512(PDGFD)
GFR: 102035549(PDGFC) 102044886(PDGFD)
FAB: 101806397(PDGFD) 101808607(PDGFC)
PHI: 102106969(PDGFC) 102112153(PDGFD)
PMAJ: 107203600(PDGFC) 107209392(PDGFD)
CCW: 104690110(PDGFD) 104697317(PDGFC)
FPG: 101910328(PDGFD) 101915028(PDGFC)
FCH: 102048020(PDGFC) 102052290(PDGFD)
CLV: 102087107(PDGFC) 102088608(PDGFD)
EGZ: 104124151(PDGFC) 104133608(PDGFD)
AAM: 106491877(PDGFC) 106495523(PDGFD)
ASN: 102378690(PDGFC) 102380973(PDGFD)
AMJ: 102569106(PDGFC) 102572032(PDGFD)
PSS: 102445898(PDGFD) 102452310(PDGFC)
CMY: 102930493(PDGFD) 102939099(PDGFC)
CPIC: 101938348(PDGFD) 101944573(PDGFC)
ACS: 100551866(pdgfd) 100568114(pdgfc)
PVT: 110072781(PDGFC) 110091114(PDGFD)
PBI: 103051428(PDGFC) 103065334(PDGFD)
GJA: 107126145(PDGFD) 107126248(PDGFC)
XLA: 108699243(pdgfc.L) 108706647(pdgfc.S) 108707572 108709984(pdgfd.S)
XTR: 100492060(pdgfd) 100494492(pdgfc)
DRE: 100535718(pdgfd) 560564(pdgfc)
IPU: 108269254(pdgfc) 108277755(pdgfd)
AMEX: 103040737(pdgfc) 103045444(pdgfd)
TRU: 101062634(pdgfc) 101063213(pdgfd)
LCO: 104928604(pdgfc) 104929855(pdgfd) 109137149
NCC: 104952384(pdgfc) 104961516(pdgfd)
MZE: 101466155(pdgfc) 101473381(pdgfd)
OLA: 101159654(pdgfc) 101163754(pdgfd)
XMA: 102217846(pdgfc) 102220475(pdgfd)
PRET: 103471839(pdgfc) 103474493(pdgfd)
NFU: 107379856(pdgfc) 107380445(pdgfd)
CSEM: 103378536(pdgfd) 103390671(pdgfc)
LCF: 108885187(pdgfc) 108886631(pdgfd)
HCQ: 109525495(pdgfd) 109526276(pdgfc)
BPEC: 110153706(pdgfc) 110174393(pdgfd)
ELS: 105024074(pdgfd) 105027646(pdgfc)
SFM: 108924448(pdgfc) 108930808 108932118(pdgfd)
LCM: 102351685(PDGFD) 102356509(PDGFC)
CMK: 103182267(pdgfc) 103185765(pdgfd)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tsai YJ, Lee RK, Lin SP, Chen YH
  Title
Identification of a novel platelet-derived growth factor-like gene, fallotein, in the human reproductive tract.
  Journal
Biochim Biophys Acta 1492:196-202 (2000)
DOI:10.1016/S0167-4781(00)00066-X
  Sequence
[hsa:56034]
Reference
  Authors
Fang L, Yan Y, Komuves LG, Yonkovich S, Sullivan CM, Stringer B, Galbraith S, Lokker NA, Hwang SS, Nurden P, Phillips DR, Giese NA
  Title
PDGF C is a selective alpha platelet-derived growth factor receptor agonist that is highly expressed in platelet alpha granules and vascular smooth muscle.
  Journal
Arterioscler Thromb Vasc Biol 24:787-92 (2004)
DOI:10.1161/01.ATV.0000120785.82268.8b
  Sequence
[mmu:54635]

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