KEGG   ORTHOLOGY: K05699Help
Entry
K05699                      KO                                     

Name
ACTN1_4
Definition
actinin alpha 1/4
Pathway
ko04510  Focal adhesion
ko04520  Adherens junction
ko04530  Tight junction
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05146  Amoebiasis
ko05203  Viral carcinogenesis
ko05322  Systemic lupus erythematosus
Disease
H00626  Focal segmental glomerulosclerosis
H01740  Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cellular community - eukaryotes
   04510 Focal adhesion
    K05699  ACTN1_4; actinin alpha 1/4
   04520 Adherens junction
    K05699  ACTN1_4; actinin alpha 1/4
   04530 Tight junction
    K05699  ACTN1_4; actinin alpha 1/4
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05699  ACTN1_4; actinin alpha 1/4
 Organismal Systems
  Immune system
   04670 Leukocyte transendothelial migration
    K05699  ACTN1_4; actinin alpha 1/4
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K05699  ACTN1_4; actinin alpha 1/4
  Immune diseases
   05322 Systemic lupus erythematosus
    K05699  ACTN1_4; actinin alpha 1/4
  Infectious diseases
   05146 Amoebiasis
    K05699  ACTN1_4; actinin alpha 1/4
Membrane trafficking [BR:ko04131]
 Exocytosis
  Small GTPases and associated proteins
   Rab associated proteins
    K05699  ACTN1_4; actinin alpha 1/4
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    Cross-linking proteins
     K05699  ACTN1_4; actinin alpha 1/4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K05699  ACTN1_4; actinin alpha 1/4
  Exosomal proteins of colorectal cancer cells
   K05699  ACTN1_4; actinin alpha 1/4
  Exosomal proteins of bladder cancer cells
   K05699  ACTN1_4; actinin alpha 1/4
BRITE hierarchy
Genes
HSA: 81(ACTN4) 87(ACTN1)
PTR: 452993(ACTN1) 456010(ACTN4)
PPS: 100979183(ACTN1) 100981951(ACTN4)
GGO: 101138551(ACTN1) 101144840(ACTN4)
PON: 100174343(ACTN4) 100460195(ACTN1)
NLE: 100588862(ACTN4) 100596303(ACTN1)
MCC: 693666(ACTN4) 711994(ACTN1)
MCF: 102125329(ACTN4) 102127552(ACTN1)
CSAB: 103229232(ACTN1) 103234638(ACTN4)
RRO: 104659630(ACTN1) 104679965(ACTN4)
RBB: 108533731(ACTN1) 108539029(ACTN4)
CJC: 100392168(ACTN4) 100406377(ACTN1)
SBQ: 101039348(ACTN1) 101050047(ACTN4)
MMU: 109711(Actn1) 60595(Actn4)
RNO: 63836(Actn4) 81634(Actn1)
CGE: 100755831(Actn1) 100766890(Actn4)
NGI: 103749304(Actn1) 103750716(Actn4)
HGL: 101710271(Actn4) 101711839(Actn1)
OCU: 100341378(ACTN1) 100351066(ACTN4)
TUP: 102493901(ACTN4) 102494430(ACTN1)
CFA: 480369(ACTN1) 484526(ACTN4)
AML: 100467263(ACTN4) 100472341(ACTN1)
UMR: 103661071(ACTN4) 103674291(ACTN1)
ORO: 101363974(ACTN4) 101368696(ACTN1)
FCA: 101093978(ACTN4) 101097986(ACTN1)
PTG: 102963733(ACTN4) 102965456(ACTN1)
AJU: 106971540(ACTN1) 106980245(ACTN4)
BTA: 522269(ACTN4) 524770(ACTN1)
BOM: 102275865(ACTN4) 102287647(ACTN1)
BIU: 109565282(ACTN1) 109572506(ACTN4)
PHD: 102336545(ACTN1) 102343227(ACTN4)
CHX: 102176966(ACTN1) 102179802(ACTN4)
OAS: 101111737(ACTN4) 101122194(ACTN1)
SSC: 100513412(ACTN1) 100517284(ACTN4)
CFR: 102511098(ACTN4) 102515180(ACTN1)
CDK: 105086159(ACTN1) 105101782(ACTN4)
BACU: 103010879(ACTN1) 103018854(ACTN4)
LVE: 103070717(ACTN4) 103088628(ACTN1)
OOR: 101278864(ACTN4) 101284859(ACTN1)
ECB: 100053070(ACTN1) 100066343(ACTN4)
EPZ: 103540812(ACTN4) 103547163(ACTN1)
EAI: 106836069(ACTN4) 106843321(ACTN1)
MYB: 102247194(ACTN1) 102250785(ACTN4)
MYD: 102762055(ACTN4) 102773341(ACTN1)
HAI: 109382080(ACTN1) 109395369(ACTN4)
RSS: 109448310(ACTN1) 109458056(ACTN4)
PALE: 102884236(ACTN4) 102887929(ACTN1)
LAV: 100655307(ACTN4) 100661051(ACTN1)
MDO: 100010983(ACTN4) 100023431(ACTN1)
SHR: 100917501(ACTN4) 100924961(ACTN1)
OAA: 100089387
GGA: 373918(ACTN1) 396024(ACTN4)
MGP: 100539916(ACTN1) 100547916
APLA: 101795217(ACTN1)
ACYG: 106031661(ACTN1)
TGU: 100221879(ACTN1)
GFR: 102033981 102042336(ACTN1)
FAB: 101814028(ACTN1)
PHI: 102100036(ACTN4) 102100480(ACTN1) 102102229
PMAJ: 107206008(ACTN1)
CCW: 104683694(ACTN1)
FPG: 101912082(ACTN1)
FCH: 102048669(ACTN1) 102059725
CLV: 102088244(ACTN1) 102090066
EGZ: 104122105(ACTN1)
AAM: 106496060 106498254(ACTN1)
ASN: 102378883(ACTN4) 102381557(ACTN1)
AMJ: 102573872(ACTN4) 106736747(ACTN1)
PSS: 102451042(ACTN4) 102453609(ACTN1)
CMY: 102929632(ACTN4) 102932714(ACTN1)
CPIC: 101932600(ACTN4) 101945411(ACTN1)
ACS: 100553987(actn1) 100566396(actn4)
PVT: 110075766(ACTN4) 110076389(ACTN1)
PBI: 103053907(ACTN1) 103054269(ACTN4)
GJA: 107106834(ACTN4) 107112209(ACTN1)
XLA: 399422(actn1.L) 431885 446865(actn4.S) 734930
XTR: 448522(actn4) 780123(actn1)
NPR: 108794113(ACTN1) 108804987(ACTN4)
DRE: 322221(actn4) 560400(actn1)
IPU: 108261236 108280413(actn4)
AMEX: 103022122(actn4) 103031817(actn1)
TRU: 101075286 101078391(actn4)
OLA: 101155449 101169077(actn1)
XMA: 102222656(actn4) 102233488
PRET: 103458304(actn1) 103475218(actn4)
NFU: 107380143(actn4) 107391737
CSEM: 103377927(actn4) 103381068(actn1)
HCQ: 109517259 109529370(actn4)
BPEC: 110157588(actn1) 110165853
SASA: 100380299(actn1) 106580854(actn4) 106600942 106612603
ELS: 105025529 105026813(actn4)
SFM: 108919448(actn1) 108924087 108928746(actn4)
LCM: 102356889(ACTN4) 102358724(ACTN1)
CMK: 103175234(actn1) 103190613
SPU: 592971
SKO: 100374060
DME: Dmel_CG4376(Actn)
DSI: Dsimw501_GD28856(Dsim_GD28856)
MDE: 101887563
AGA: AgaP_AGAP001497(ACTN_ANOGA)
AAG: 5568986
AME: 725782(Actn)
BIM: 100749119
BTER: 100652204
SOC: 105201176
AEC: 105146320
ACEP: 105620710
PBAR: 105426241
HST: 105189773
CFO: 105250976
LHU: 105673416
PGC: 109863707
NVI: 100118107
TCA: 661042
DPA: 109535688
NVL: 108556321
BMOR: 101742794
PMAC: 106710704
PRAP: 111004138
API: 100159279
DNX: 107170710
ZNE: 110832782
FCD: 110844414
TUT: 107360403
CEL: CELE_W04D2.1(atn-1)
CBR: CBG23504(Cbr-atn-1)
BMY: Bm1_51465
TSP: Tsp_06092
CRG: 105326760
MYI: 110459175
OBI: 106875711
LAK: 106156043
EPA: 110233331
ADF: 107344902
HMG: 100215556
AQU: 100633045
DFA: DFA_04278(abpA)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2349951
  Authors
Youssoufian H, McAfee M, Kwiatkowski DJ
  Title
Cloning and chromosomal localization of the human cytoskeletal alpha-actinin gene reveals linkage to the beta-spectrin gene.
  Journal
Am J Hum Genet 47:62-72 (1990)
  Sequence
[hsa:87]
Reference
  Authors
Nikolopoulos SN, Spengler BA, Kisselbach K, Evans AE, Biedler JL, Ross RA
  Title
The human non-muscle alpha-actinin protein encoded by the ACTN4 gene suppresses tumorigenicity of human neuroblastoma cells.
  Journal
Oncogene 19:380-6 (2000)
DOI:10.1038/sj.onc.1203310
  Sequence
[hsa:81]

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