KEGG   ORTHOLOGY: K05731Help
Entry
K05731                      KO                                     

Name
TIAM1
Definition
T-lymphoma invasion and metastasis-inducing protein 1
Pathway
Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Chemokine signaling pathway
Tight junction
Regulation of actin cytoskeleton
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04015 Rap1 signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04024 cAMP signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 Cellular Processes
  Cellular community - eukaryotes
   04530 Tight junction
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
BRITE hierarchy
Genes
HSA: 
7074(TIAM1)
PTR: 
473949(TIAM1)
PPS: 
100967869(TIAM1)
GGO: 
101125464(TIAM1)
PON: 
100431618(TIAM1)
NLE: 
100605316(TIAM1)
MCC: 
702288(TIAM1)
MCF: 
101865530(TIAM1)
CSAB: 
103217191(TIAM1)
RRO: 
104664652(TIAM1)
CJC: 
100390844(TIAM1)
SBQ: 
101042162(TIAM1)
MMU: 
21844(Tiam1)
RNO: 
304109(Tiam1)
CGE: 
100756100(Tiam1)
NGI: 
103736475(Tiam1)
HGL: 
101711984(Tiam1)
OCU: 
100338333(TIAM1)
TUP: 
102500733(TIAM1)
CFA: 
487731(TIAM1)
AML: 
UMR: 
103673212(TIAM1)
FCA: 
101094530(TIAM1)
PTG: 
102955456(TIAM1)
AJU: 
106977842(TIAM1)
BTA: 
536517(TIAM1)
BOM: 
102283572(TIAM1)
PHD: 
102343415(TIAM1)
CHX: 
102170463(TIAM1)
OAS: 
101103280(TIAM1)
SSC: 
100524587(TIAM1)
CFR: 
102519655(TIAM1)
BACU: 
103016623(TIAM1)
LVE: 
103073449(TIAM1)
ECB: 
100052764(TIAM1)
MYB: 
102243024(TIAM1)
MYD: 
102761891(TIAM1)
HAI: 
109393508(TIAM1)
PALE: 
102883973(TIAM1)
LAV: 
100675466(TIAM1)
MDO: 
100015064(TIAM1)
SHR: 
100920711(TIAM1)
GGA: 
418491(TIAM1)
MGP: 
100540208(TIAM1)
CJO: 
107322765(TIAM1)
APLA: 
101803496(TIAM1)
TGU: 
100219509(TIAM1)
GFR: 
102040520(TIAM1)
FAB: 
101806275(TIAM1)
PHI: 
102109961(TIAM1)
CCW: 
104684195(TIAM1)
FPG: 
101914291(TIAM1)
FCH: 
102057263(TIAM1)
CLV: 
102098791(TIAM1)
AAM: 
106494979(TIAM1)
ASN: 
102385589(TIAM1)
AMJ: 
106737085(TIAM1)
PSS: 
102446695(TIAM1)
CMY: 
102934808(TIAM1)
CPIC: 
101936219(TIAM1)
ACS: 
100555790(tiam1)
PBI: 
103061969(TIAM1)
GJA: 
XLA: 
108707884 735176(tiam1.S)
XTR: 
734013(tiam1)
DRE: 
567621(tiam1a)
IPU: 
TRU: 
TNG: 
LCO: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102353813(TIAM1)
CMK: 
103185540(tiam1)
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
725970(GB10237)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
LGI: 
CRG: 
OBI: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Minard ME, Kim LS, Price JE, Gallick GE
  Title
The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.
  Journal
Breast Cancer Res Treat 84:21-32 (2004)
Reference
  Authors
Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ
  Title
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
  Journal
J Mol Biol 398:730-46 (2010)
Reference
PMID:7999144
  Authors
Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A, Collard JG
  Title
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with  homology to GDP-GTP exchangers for Rho-like proteins.
  Journal
Cell 77:537-49 (1994)
  Sequence
[mmu:21844]

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