KEGG   ORTHOLOGY: K05731Help
Entry
K05731                      KO                                     

Name
TIAM1
Definition
T-lymphoma invasion and metastasis-inducing protein 1
Pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04530  Tight junction
ko04810  Regulation of actin cytoskeleton
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04015 Rap1 signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
   04024 cAMP signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 Cellular Processes
  Cellular community - eukaryotes
   04530 Tight junction
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K05731  TIAM1; T-lymphoma invasion and metastasis-inducing protein 1
BRITE hierarchy
Genes
HSA: 7074(TIAM1)
PTR: 473949(TIAM1)
PPS: 100967869(TIAM1)
GGO: 101125464(TIAM1)
PON: 100431618(TIAM1)
NLE: 100605316(TIAM1)
MCC: 702288(TIAM1)
MCF: 101865530(TIAM1)
CSAB: 103217191(TIAM1)
RRO: 104664652(TIAM1)
RBB: 108536834(TIAM1)
CJC: 100390844(TIAM1)
SBQ: 101042162(TIAM1)
MMU: 21844(Tiam1)
RNO: 304109(Tiam1)
CGE: 100756100(Tiam1)
NGI: 103736475(Tiam1)
HGL: 101711984(Tiam1)
CCAN: 109700897(Tiam1)
OCU: 100338333(TIAM1)
TUP: 102500733(TIAM1)
CFA: 487731(TIAM1)
AML: 100478016 105242089(TIAM1)
UMR: 103673212(TIAM1)
ORO: 101365424(TIAM1)
FCA: 101094530(TIAM1)
PTG: 102955456(TIAM1)
AJU: 106977842(TIAM1)
BTA: 536517(TIAM1)
BOM: 102283572(TIAM1)
BIU: 109562052(TIAM1)
PHD: 102343415(TIAM1)
CHX: 102170463(TIAM1)
OAS: 101103280(TIAM1)
SSC: 100524587(TIAM1)
CFR: 102519655(TIAM1)
CDK: 105086777(TIAM1)
BACU: 103016623(TIAM1)
LVE: 103073449(TIAM1)
OOR: 101280455(TIAM1)
ECB: 100052764(TIAM1)
EPZ: 103550555(TIAM1)
EAI: 106847274(TIAM1)
MYB: 102243024(TIAM1)
MYD: 102761891(TIAM1)
HAI: 109393508(TIAM1)
RSS: 109446603(TIAM1)
PALE: 102883973(TIAM1)
LAV: 100675466(TIAM1)
TMU: 101352570
MDO: 100015064(TIAM1)
SHR: 100920711(TIAM1)
GGA: 418491(TIAM1)
MGP: 100540208(TIAM1)
CJO: 107322765(TIAM1)
APLA: 101803496(TIAM1)
ACYG: 106043428(TIAM1)
TGU: 100219509(TIAM1)
GFR: 102040520(TIAM1)
FAB: 101806275(TIAM1)
PHI: 102109961(TIAM1)
PMAJ: 107213264(TIAM1)
CCW: 104684195(TIAM1)
FPG: 101914291(TIAM1)
FCH: 102057263(TIAM1)
CLV: 102098791(TIAM1)
EGZ: 104128218(TIAM1)
AAM: 106494979(TIAM1)
ASN: 102385589(TIAM1)
AMJ: 106737085(TIAM1)
PSS: 102446695(TIAM1)
CMY: 102934808(TIAM1)
CPIC: 101936219(TIAM1)
ACS: 100555790(tiam1)
PVT: 110080375(TIAM1)
PBI: 103061969(TIAM1)
GJA: 107108355 107109049(TIAM1)
XLA: 108707884 735176(tiam1.S)
XTR: 734013(tiam1)
NPR: 108787811(TIAM1)
DRE: 567621(tiam1a)
IPU: 108277166(tiam1) 108278361
AMEX: 103029595(tiam1) 103039111
TRU: 101072336 101079238(tiam1)
LCO: 104923304(tiam1) 104923828
MZE: 101474606(tiam1) 101482226
SFM: 108936219(tiam1) 108941465
LCM: 102353813(TIAM1)
CMK: 103185540(tiam1)
SPU: 583804
APLC: 110974361
SKO: 100367282
DME: Dmel_CG34418(sif)
MDE: 101894603
AAG: 5564449
AME: 725970(GB10237)
BIM: 100746246
BTER: 100647149
SOC: 105200529
AEC: 105150007
ACEP: 105617831
PBAR: 105429920
HST: 105190880
CFO: 105255221
LHU: 105677918
PGC: 109857162
NVI: 100115302
TCA: 662876
DPA: 109533127
BMOR: 101739475
PMAC: 106714985
PRAP: 110994691
PXY: 105384178
API: 100163095
ZNE: 110840486
FCD: 110854079
TUT: 107366482
CRG: 105331449
MYI: 110455449
OBI: 106871954
LAK: 106178751
EPA: 110250002
ADF: 107335564
AQU: 109581571
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Minard ME, Kim LS, Price JE, Gallick GE
  Title
The role of the guanine nucleotide exchange factor Tiam1 in cellular migration, invasion, adhesion and tumor progression.
  Journal
Breast Cancer Res Treat 84:21-32 (2004)
DOI:10.1023/B:BREA.0000018421.31632.e6
Reference
  Authors
Shepherd TR, Klaus SM, Liu X, Ramaswamy S, DeMali KA, Fuentes EJ
  Title
The Tiam1 PDZ domain couples to Syndecan1 and promotes cell-matrix adhesion.
  Journal
J Mol Biol 398:730-46 (2010)
DOI:10.1016/j.jmb.2010.03.047
Reference
PMID:7999144
  Authors
Habets GG, Scholtes EH, Zuydgeest D, van der Kammen RA, Stam JC, Berns A, Collard JG
  Title
Identification of an invasion-inducing gene, Tiam-1, that encodes a protein with homology to GDP-GTP exchangers for Rho-like proteins.
  Journal
Cell 77:537-49 (1994)
DOI:10.1016/0092-8674(94)90216-X
  Sequence
[mmu:21844]

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