KEGG   ORTHOLOGY: K05747Help
Entry
K05747                      KO                                     

Name
WAS
Definition
Wiskott-Aldrich syndrome protein
Pathway
Chemokine signaling pathway
Adherens junction
Fc gamma R-mediated phagocytosis
Regulation of actin cytoskeleton
Bacterial invasion of epithelial cells
Pathogenic Escherichia coli infection
Shigellosis
Salmonella infection
Choline metabolism in cancer
Disease
H00100  
Neutropenic disorders
H00107  
Other well-defined immunodeficiency syndromes
H00978  
Thrombocytopenia (THC)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K05747  WAS; Wiskott-Aldrich syndrome protein
  Cellular commiunity
   04520 Adherens junction
    K05747  WAS; Wiskott-Aldrich syndrome protein
 Organismal Systems
  Immune system
   04666 Fc gamma R-mediated phagocytosis
    K05747  WAS; Wiskott-Aldrich syndrome protein
   04062 Chemokine signaling pathway
    K05747  WAS; Wiskott-Aldrich syndrome protein
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K05747  WAS; Wiskott-Aldrich syndrome protein
  Infectious diseases
   05130 Pathogenic Escherichia coli infection
    K05747  WAS; Wiskott-Aldrich syndrome protein
   05132 Salmonella infection
    K05747  WAS; Wiskott-Aldrich syndrome protein
   05131 Shigellosis
    K05747  WAS; Wiskott-Aldrich syndrome protein
   05100 Bacterial invasion of epithelial cells
    K05747  WAS; Wiskott-Aldrich syndrome protein
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actin-binding proteins
    WASP / WAVE
     K05747  WAS; Wiskott-Aldrich syndrome protein
BRITE hierarchy
Genes
HSA: 
7454(WAS) 8976(WASL)
PTR: 
463688(WASL)
PPS: 
100977168(WAS) 100988895(WASL)
GGO: 
PON: 
100171409(WASL) 100452449(WAS)
NLE: 
100581906(WASL) 100598058(WAS)
MCC: 
MCF: 
CJC: 
100411440(WASL) 100412947(WAS)
MMU: 
22376(Was) 73178(Wasl)
RNO: 
317371(Was) 682507(Wasl)
CGE: 
100757697(Wasl) 100769113(Was)
NGI: 
103727083(Wasl) 103741643(Was)
HGL: 
101700594(Wasl) 101704700(Was)
OCU: 
100347053(WASL) 100354471(WAS)
TUP: 
102469132(WAS) 102482798(WASL)
CFA: 
475213(WASL) 491867(WAS)
AML: 
UMR: 
103663384(WAS) 103676615(WASL)
FCA: 
101095243(WASL) 101095721(WAS)
PTG: 
102951203(WAS) 102972678(WASL)
BTA: 
100336547(WAS) 281577(WASL)
BOM: 
102271473(WAS) 102284135(WASL)
PHD: 
102316881(WASL) 102337766(WAS)
CHX: 
102183859(WAS) 102188466(WASL)
OAS: 
101106932(WASL) 101114336(WAS)
SSC: 
100525017(WASL)
CFR: 
102504610(WASL) 102512738(WAS)
BACU: 
103010568(WASL) 103013907(WAS)
LVE: 
103073648(WAS) 103082660(WASL)
ECB: 
MYB: 
102242874(WAS) 102251680(WASL)
MYD: 
102757603(WASL) 102763663(WAS)
PALE: 
102878816(WASL) 102888774(WAS)
MDO: 
100013566(WASL) 100018699(WAS)
SHR: 
OAA: 
100076423(WASL) 100089883(WAS)
GGA: 
417750(WASL)
MGP: 
APLA: 
101797340(WASL)
TGU: 
100228869(WASL)
FAB: 
101817185(WASL)
PHI: 
FPG: 
101918244(WASL)
FCH: 
102048671(WASL)
CLV: 
102095528(WASL)
ASN: 
102370091(WAS) 102383791(WASL)
AMJ: 
102561988(WAS) 102573657(WASL)
PSS: 
102458122(WASL)
CMY: 
102933050(WASL) 102938058(WAS)
ACS: 
PBI: 
103051900(WAS) 103055172(WASL)
XLA: 
XTR: 
407864(wasl) 496673(was)
DRE: 
100009637(wasla) 335158(wasb) 394034(waslb) 571256(wasa)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
409218(WASp)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG01563(Cbr-wsp-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
PIC: 
CNE: 
CNB: 
CGI: 
TMS: 
DSQ: 
PSQ: 
ADL: 
UMA: 
PFP: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
EHX: 
NGR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Miki H, Takenawa T
  Title
Regulation of actin dynamics by WASP family proteins.
  Journal
J Biochem 134:309-13 (2003)
Reference
  Authors
Cory GO, Garg R, Cramer R, Ridley AJ
  Title
Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott-Aldrich Syndrome protein.
  Journal
J Biol Chem 277:45115-21 (2002)
  Sequence
[hsa:7454]

DBGET integrated database retrieval system