KEGG   ORTHOLOGY: K05856Help
Entry
K05856                      KO                                     

Name
LCK
Definition
lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
Pathway
NF-kappa B signaling pathway
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
HTLV-I infection
Primary immunodeficiency
Disease
H00093  
Combined immunodeficiencies (CIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04660 T cell receptor signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04658 Th1 and Th2 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04659 Th17 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  Development
   04380 Osteoclast differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 Human Diseases
  Immune diseases
   05340 Primary immunodeficiency
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  Infectious diseases
   05166 HTLV-I infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  Src family
   K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   CD2 family
    CD48, BCM1; CD48 antigen
     K05856 LCK; lymphocyte cell-specific protein tyrosine kinase
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3932(LCK)
PTR: 
456715(LCK)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
717704(LCK)
MCF: 
CSAB: 
RRO: 
RBB: 
CJC: 
SBQ: 
MMU: 
16818(Lck)
RNO: 
313050(Lck)
CGE: 
NGI: 
HGL: 
CCAN: 
OCU: 
TUP: 
CFA: 
478151(LCK)
AML: 
UMR: 
FCA: 
PTG: 
AJU: 
BTA: 
508890(LCK)
BOM: 
BIU: 
PHD: 
CHX: 
OAS: 
SSC: 
CFR: 
CDK: 
BACU: 
LVE: 
ECB: 
EPZ: 
EAI: 
MYB: 
MYD: 
HAI: 
RSS: 
PALE: 
LAV: 
MDO: 
SHR: 
OAA: 
GGA: 
396460(LCK)
MGP: 
CJO: 
APLA: 
ACYG: 
GFR: 
FAB: 
PHI: 
PMAJ: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
PSS: 
CMY: 
CPIC: 
ACS: 
PVT: 
PBI: 
GJA: 
XLA: 
100036955(lck.L) 108708930(lck.S)
XTR: 
NPR: 
DRE: 
414333(lck)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
SPAR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3493153
  Authors
Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak TW
  Title
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.
  Journal
Eur J Immunol 16:1643-6 (1986)
DOI:10.1002/eji.1830161229
  Sequence
[hsa:3932]
Reference
PMID:8293463
  Authors
Weiss A, Littman DR
  Title
Signal transduction by lymphocyte antigen receptors.
  Journal
Cell 76:263-74 (1994)
DOI:10.1016/0092-8674(94)90334-4
Reference
  Authors
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM
  Title
Centrosome docking at the immunological synapse is controlled by Lck signaling.
  Journal
J Cell Biol 192:663-74 (2011)
DOI:10.1083/jcb.201008140

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