KEGG   ORTHOLOGY: K06030Help
Entry
K06030                      KO                                     

Name
MFN2, FZO1
Definition
mitofusin 2 [EC:3.6.5.-]
Pathway
ko04137  Mitophagy - animal
ko04214  Apoptosis - fly
ko04621  NOD-like receptor signaling pathway
Disease
H00264  Charcot-Marie-Tooth disease (CMT)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Transport and catabolism
   04137 Mitophagy - animal
    K06030  MFN2, FZO1; mitofusin 2
  Cell growth and death
   04214 Apoptosis - fly
    K06030  MFN2, FZO1; mitofusin 2
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    K06030  MFN2, FZO1; mitofusin 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.5  Acting on GTP to facilitate cellular and subcellular movement
    3.6.5.-  
     K06030  MFN2, FZO1; mitofusin 2
Membrane trafficking [BR:ko04131]
 Autophagy
  Mitophagy
   PINK1-Parkin associated proteins
    K06030  MFN2, FZO1; mitofusin 2
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Mitochondrial dynamics
   Fission and Fusion factors
    K06030  MFN2, FZO1; mitofusin 2
BRITE hierarchy
Other DBs
COG: COG0699
TC: 9.B.25.1 9.B.25.2
Genes
HSA: 9927(MFN2)
PTR: 457958(MFN2)
PPS: 100973903(MFN2)
GGO: 101135459(MFN2)
PON: 100172672(MFN2)
NLE: 100599174(MFN2)
MCC: 100427191(MFN2)
MCF: 101926564(MFN2)
CSAB: 103225593(MFN2)
RRO: 104659369 104668934(MFN2)
RBB: 108539352(MFN2)
CJC: 100412019(MFN2)
SBQ: 101041459(MFN2)
MMU: 170731(Mfn2)
RNO: 100911485 64476(Mfn2)
CGE: 100763273(Mfn2)
NGI: 103747475(Mfn2)
HGL: 101715674(Mfn2)
CCAN: 109683965(Mfn2)
OCU: 100350119(MFN2)
TUP: 102474328(MFN2)
CFA: 487439(MFN2)
AML: 100470367(MFN2)
UMR: 103666645(MFN2)
ORO: 101369854(MFN2)
FCA: 101101068(MFN2)
PTG: 102972369(MFN2)
AJU: 106989449(MFN2)
BTA: 534574(MFN2)
BOM: 102264443(MFN2)
BIU: 109570412(MFN2)
PHD: 102325080(MFN2)
CHX: 102181325(MFN2)
OAS: 101110526(MFN2)
SSC: 100512354(MFN2)
CFR: 102504460(MFN2)
CDK: 105107041(MFN2)
BACU: 103019535(MFN2)
LVE: 103081252(MFN2)
OOR: 101289484(MFN2)
ECB: 100055966(MFN2)
EPZ: 103552179(MFN2)
EAI: 106836664(MFN2)
MYB: 102246147(MFN2)
MYD: 102763805(MFN2)
HAI: 109381283(MFN2)
RSS: 109460675(MFN2)
PALE: 102881288(MFN2)
LAV: 100657545(MFN2)
TMU: 101360670
MDO: 100013425(MFN2)
SHR: 100915154 100928115(MFN2)
GGA: 419484(MFN2)
MGP: 100542450(MFN2)
CJO: 107323369(MFN2)
APLA: 101791051(MFN2)
ACYG: 106040209(MFN2)
TGU: 100230233(MFN2)
GFR: 102032568(MFN2)
FAB: 101815947(MFN2)
PHI: 102110409(MFN2)
PMAJ: 107213712(MFN2)
CCW: 104693246(MFN2)
FPG: 101921025(MFN2)
FCH: 102053459(MFN2)
CLV: 102088591(MFN2)
EGZ: 104133089(MFN2)
AAM: 106482467(MFN2)
ASN: 102374370(MFN2)
AMJ: 102572527(MFN2)
PSS: 102447012(MFN2)
CMY: 102944655(MFN2)
CPIC: 101943561(MFN2)
ACS: 100557065(mfn2)
PVT: 110073212(MFN2)
PBI: 103066015(MFN2)
GJA: 107111574(MFN2)
XLA: 108697551(mfn2.S) 431918(mfn2.L)
XTR: 549268(mfn2)
NPR: 108798426(MFN2)
DRE: 567448(mfn2)
IPU: 108265739(mfn2)
AMEX: 103030025(mfn2)
TRU: 101071552(mfn2)
LCO: 104932314(mfn2)
MZE: 101476877(mfn2)
OLA: 101170481(mfn2)
XMA: 102236418(mfn2)
PRET: 103466977(mfn2)
NFU: 107390565(mfn2)
CSEM: 103384844(mfn2)
LCF: 108900504(mfn2)
HCQ: 109528670(mfn2)
SASA: 106572197(mfn2)
ELS: 105013857(mfn2)
SFM: 108924939(mfn2)
LCM: 102356846(MFN2)
CMK: 103181399(mfn2)
CIN: 100186475(mfn2)
SPU: 590207
APLC: 110982308
SKO: 102800824
DME: Dmel_CG3869(Marf) Dmel_CG4568(fzo)
DSI: Dsimw501_GD16797(Dsim_GD16797) Dsimw501_GD28586(Dsim_GD28586)
DMO: Dmoj_GI15189(Dmoj_Marf) Dmoj_GI26396
MDE: 101901601
AAG: 5564882
AME: 410263(Marf)
BIM: 100746892
BTER: 100646597
AEC: 105151679
ACEP: 105620404
PBAR: 105426270
HST: 105190222
CFO: 105253002
LHU: 105671492
PGC: 109854036
NVI: 100121959
TCA: 658690
DPA: 109540118
NVL: 108566432
BMOR: 101737843
PMAC: 106718413
PRAP: 111000195
PXY: 105382934
API: 100166803
DNX: 107168084
ZNE: 110831218
FCD: 110846703
TUT: 107361953
CEL: CELE_ZK1248.14(fzo-1)
CBR: CBG02514(Cbr-fzo-1)
BMY: Bm1_09110
TSP: Tsp_07217
MYI: 110450460
OBI: 106881618
SHX: MS3_04534
EPA: 110251765
HMG: 100205666
SCE: YBR179C(FZO1)
ERC: Ecym_7066
KMX: KLMA_10794(FZO1)
NCS: NCAS_0B01990(NCAS0B01990)
NDI: NDAI_0C05690(NDAI0C05690)
TPF: TPHA_0A01290(TPHA0A01290)
TBL: TBLA_0H03810(TBLA0H03810)
TDL: TDEL_0A05160(TDEL0A05160)
KAF: KAFR_0I00690(KAFR0I00690)
CAL: CAALFM_C404260CA(FZO1)
CAUR: QG37_02485
SLB: AWJ20_1158(FZO1)
NCR: NCU00436(uvs-5)
NTE: NEUTE1DRAFT82395(NEUTE1DRAFT_82395)
MGR: MGG_05209
MAJ: MAA_05849
CMT: CCM_09450
BFU: BCIN_03g01740(Bcfzo1)
MBE: MBM_01833
ANI: AN6897.2
ANG: ANI_1_676124(An14g04870)
ABE: ARB_03335
TVE: TRV_04155
PNO: SNOG_10786(SNOG_10785)
PTE: PTT_11757
SPO: SPBC1706.03(fzo1)
CNE: CNF03260
CNB: CNBF1520
ABP: AGABI1DRAFT120610(AGABI1DRAFT_120610)
ABV: AGABI2DRAFT119324(AGABI2DRAFT_119324)
MGL: MGL_1150
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Chen KH, Guo X, Ma D, Guo Y, Li Q, Yang D, Li P, Qiu X, Wen S, Xiao RP, Tang J
  Title
Dysregulation of HSG triggers vascular proliferative disorders.
  Journal
Nat Cell Biol 6:872-83 (2004)
DOI:10.1038/ncb1161
  Sequence
[hsa:9927]
Reference
  Authors
Chen Y, Dorn GW 2nd
  Title
PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria.
  Journal
Science 340:471-5 (2013)
DOI:10.1126/science.1231031
  Sequence
[hsa:9927]
Reference
PMID:9786948
  Authors
Hermann GJ, Thatcher JW, Mills JP, Hales KG, Fuller MT, Nunnari J, Shaw JM
  Title
Mitochondrial fusion in yeast requires the transmembrane GTPase Fzo1p.
  Journal
J Cell Biol 143:359-73 (1998)
DOI:10.1083/jcb.143.2.359
  Sequence
[sce:YBR179C]

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