KEGG   ORTHOLOGY: K06059Help
Entry
K06059                      KO                                     

Name
ADAM17, TACE, CD156b
Definition
disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Pathway
Notch signaling pathway
Alzheimer's disease
Epithelial cell signaling in Helicobacter pylori infection
Module
M00682  
Notch signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04330 Notch signaling pathway
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00682  Notch signaling
     K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Peptidases [BR:ko01002]
 Metallo Peptidases
  Family M12: astacin/adamalysin family
   K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-5
    ITGB1; integrin beta 1
     K06059 ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Cellular antigens [BR:ko04090]
 Proteins
  K06059  CD156b, ADAM17; a disintegrin and metalloproteinase domain 17
BRITE hierarchy
Genes
HSA: 
6868(ADAM17)
PTR: 
459018(ADAM17)
PPS: 
100988650(ADAM17)
GGO: 
PON: 
100439426(ADAM17)
NLE: 
100605134(ADAM17)
MCC: 
694429(ADAM17)
MCF: 
102116784(ADAM17)
CSAB: 
103220846(ADAM17)
RRO: 
104675213(ADAM17)
CJC: 
100406520(ADAM17)
SBQ: 
101049053(ADAM17)
MMU: 
11491(Adam17)
RNO: 
57027(Adam17)
CGE: 
100684971(Adam17)
NGI: 
103747629(Adam17)
HGL: 
101720924(Adam17)
OCU: 
100101613(ADAM17)
TUP: 
102496316(ADAM17)
CFA: 
475662(ADAM17)
AML: 
100482770(ADAM17)
UMR: 
103675912(ADAM17)
FCA: 
101089004(ADAM17)
PTG: 
102948618(ADAM17)
BTA: 
517541(ADAM17)
BOM: 
102279111(ADAM17)
PHD: 
102319953(ADAM17)
CHX: 
102188327(ADAM17)
OAS: 
101116815(ADAM17)
SSC: 
CFR: 
102508816(ADAM17)
BACU: 
103004501(ADAM17)
LVE: 
103086820(ADAM17)
ECB: 
100072496(ADAM17)
MYB: 
102256292(ADAM17)
MYD: 
102767398(ADAM17)
PALE: 
102894565(ADAM17)
LAV: 
100663807(ADAM17)
MDO: 
100032069(ADAM17)
SHR: 
100926795(ADAM17)
OAA: 
100086345(ADAM17)
GGA: 
421931(ADAM17)
MGP: 
100549409(ADAM17)
CJO: 
107312200(ADAM17)
APLA: 
101794295(ADAM17)
TGU: 
100225922(ADAM17)
GFR: 
102034165(ADAM17)
FAB: 
101814343(ADAM17)
PHI: 
102106429(ADAM17)
CCW: 
104685448(ADAM17)
FPG: 
101924106(ADAM17)
FCH: 
102055911(ADAM17)
CLV: 
102098173(ADAM17)
AAM: 
106494759(ADAM17)
ASN: 
102373202(ADAM17)
AMJ: 
102560812(ADAM17)
PSS: 
102454376(ADAM17)
CMY: 
102933390(ADAM17)
ACS: 
100563907(adam17)
PBI: 
103060091(ADAM17)
GJA: 
107112820(ADAM17)
XLA: 
733430(adam17.L)
XTR: 
100492947(adam17)
DRE: 
324142(adam17a) 560657(adam17b)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102367618(ADAM17)
CMK: 
103187122(adam17)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD21492(Dsim_GD21492)
DWI: 
DYA: 
Dyak_GE10847(dyak_GLEANR_10737)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
CEL: 
CBR: 
CBG16796(Cbr-adm-4)
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
ADF: 
HMG: 
TAD: 
AQU: 
MBR: 
SRE: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9034191
  Authors
Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Becherer JD, et al.
  Title
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
  Journal
Nature 385:733-6 (1997)
  Sequence
[hsa:6868]
Reference
  Authors
Thathiah A, Blobel CP, Carson DD
  Title
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.
  Journal
J Biol Chem 278:3386-94 (2003)

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