KEGG   ORTHOLOGY: K06059Help
Entry
K06059                      KO                                     

Name
ADAM17, TACE, CD156b
Definition
disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Pathway
ko04330  Notch signaling pathway
ko05010  Alzheimer's disease
ko05120  Epithelial cell signaling in Helicobacter pylori infection
Module
M00682  Notch signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04330 Notch signaling pathway
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00682  Notch signaling
     K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Peptidases [BR:ko01002]
 Metallo Peptidases
  Family M12: astacin/adamalysin family
   K06059  ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-5
    ITGB1; integrin beta 1
     K06059 ADAM17, TACE, CD156b; disintegrin and metalloproteinase domain-containing protein 17
CD molecules [BR:ko04090]
 Proteins
  K06059  CD156b, ADAM17; a disintegrin and metalloproteinase domain 17
BRITE hierarchy
Genes
HSA: 6868(ADAM17)
PTR: 459018(ADAM17)
PPS: 100988650(ADAM17)
GGO: 101152705(ADAM17)
PON: 100439426(ADAM17)
NLE: 100605134(ADAM17)
MCC: 694429(ADAM17)
MCF: 102116784(ADAM17)
CSAB: 103220846(ADAM17)
RRO: 104675213(ADAM17)
RBB: 108516165(ADAM17)
CJC: 100406520(ADAM17)
SBQ: 101049053(ADAM17)
MMU: 11491(Adam17)
RNO: 57027(Adam17)
CGE: 100684971(Adam17)
NGI: 103747629(Adam17)
HGL: 101720924(Adam17)
CCAN: 109695934(Adam17)
OCU: 100101613(ADAM17)
TUP: 102496316(ADAM17)
CFA: 475662(ADAM17)
AML: 100482770(ADAM17)
UMR: 103675912(ADAM17)
ORO: 101378266(ADAM17)
FCA: 101089004(ADAM17)
PTG: 102948618(ADAM17)
AJU: 106982950(ADAM17)
BTA: 517541(ADAM17)
BOM: 102279111(ADAM17)
BIU: 109566404(ADAM17)
PHD: 102319953(ADAM17)
CHX: 102188327(ADAM17)
OAS: 101116815(ADAM17)
SSC: 397343(ADAM17)
CFR: 102508816(ADAM17)
CDK: 105091236(ADAM17)
BACU: 103004501(ADAM17)
LVE: 103086820(ADAM17)
OOR: 101272366(ADAM17)
ECB: 100072496(ADAM17)
EPZ: 103543937 103560849(ADAM17)
EAI: 106847480(ADAM17)
MYB: 102256292(ADAM17)
MYD: 102767398(ADAM17)
HAI: 109386655(ADAM17)
RSS: 109460495(ADAM17)
PALE: 102894565(ADAM17)
LAV: 100663807(ADAM17)
TMU: 101350544
MDO: 100032069(ADAM17)
SHR: 100926795(ADAM17)
OAA: 100086345(ADAM17)
GGA: 421931(ADAM17)
MGP: 100549409(ADAM17)
CJO: 107312200(ADAM17)
APLA: 101794295(ADAM17)
ACYG: 106030708(ADAM17)
TGU: 100225922(ADAM17)
GFR: 102034165(ADAM17)
FAB: 101814343(ADAM17)
PHI: 102106429(ADAM17)
PMAJ: 107201529(ADAM17)
CCW: 104685448(ADAM17)
FPG: 101924106(ADAM17)
FCH: 102055911(ADAM17)
CLV: 102098173(ADAM17)
EGZ: 104127159(ADAM17)
AAM: 106494759(ADAM17)
ASN: 102373202(ADAM17)
AMJ: 102560812(ADAM17)
PSS: 102454376(ADAM17)
CMY: 102933390(ADAM17)
CPIC: 101938160(ADAM17)
ACS: 100563907(adam17)
PVT: 110080585(ADAM17)
PBI: 103060091(ADAM17)
GJA: 107112820(ADAM17)
XLA: 108718238(adam17.S) 733430(adam17.L)
XTR: 100492947(adam17)
NPR: 108789869(ADAM17)
DRE: 324142(adam17a) 560657(adam17b)
IPU: 108257789 108270063(Adam17)
TRU: 101063716(adam17) 101075639
LCO: 104922135(adam17) 104938532
NCC: 104953609(adam17)
XMA: 102222153 102227287(adam17)
PRET: 103457157(adam17) 103458871
NFU: 107377926 107392286(adam17)
CSEM: 103377555(adam17) 103381366
LCF: 108888136(adam17) 108891569
HCQ: 109526133(adam17) 109531720
BPEC: 110155414(adam17) 110164254
ELS: 105016077(adam17) 105017805
SFM: 108921884(adam17)
LCM: 102367618(ADAM17)
CMK: 103187122(adam17)
CIN: 100175230
SPU: 585715
APLC: 110985040
SKO: 102803736
DME: Dmel_CG7908(Tace)
DSI: Dsimw501_GD21492(Dsim_GD21492)
MDE: 101891592
AAG: 5563722
AME: 551599
BIM: 100745543
BTER: 100645870
SOC: 105197464
AEC: 105143101
ACEP: 105623272
PBAR: 105427116
HST: 105184135
LHU: 105669279
PGC: 109861730
NVI: 100119121
TCA: 663540
DPA: 109537991
NVL: 108563900
BMOR: 101742406
PRAP: 111003508
API: 100158671
DNX: 107167450
ZNE: 110836194
FCD: 110845600
CEL: CELE_ZK154.7(adm-4)
CBR: CBG16796(Cbr-adm-4)
TSP: Tsp_02601
OBI: 106881514
SHX: MS3_01883
EPA: 110250562
ADF: 107358831
HMG: 100210793
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9034191
  Authors
Moss ML, Jin SL, Milla ME, Bickett DM, Burkhart W, Carter HL, Chen WJ, Clay WC, Didsbury JR, Hassler D, Hoffman CR, Kost TA, Lambert MH, Leesnitzer MA, McCauley P, McGeehan G, Mitchell J, Moyer M, Pahel G, Rocque W, Overton LK, Schoenen F, Seaton T, Su JL, Becherer JD, et al.
  Title
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
  Journal
Nature 385:733-6 (1997)
DOI:10.1038/385733a0
  Sequence
[hsa:6868]
Reference
  Authors
Thathiah A, Blobel CP, Carson DD
  Title
Tumor necrosis factor-alpha converting enzyme/ADAM 17 mediates MUC1 shedding.
  Journal
J Biol Chem 278:3386-94 (2003)
DOI:10.1074/jbc.M208326200

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