KEGG   ORTHOLOGY: K06059Help
Entry
K06059                      KO                                     

Name
ADAM17, TACE
Definition
disintegrin and metalloproteinase domain-containing protein 17 [EC:3.4.24.86]
Pathway
Notch signaling pathway
Alzheimer's disease
Epithelial cell signaling in Helicobacter pylori infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04330 Notch signaling pathway
    K06059  ADAM17, TACE; disintegrin and metalloproteinase domain-containing protein 17
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K06059  ADAM17, TACE; disintegrin and metalloproteinase domain-containing protein 17
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K06059  ADAM17, TACE; disintegrin and metalloproteinase domain-containing protein 17
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.86  ADAM 17 endopeptidase
     K06059  ADAM17, TACE; disintegrin and metalloproteinase domain-containing protein 17
Peptidases [BR:ko01002]
 Metallo Peptidases
  Family M12: astacin/adamalysin family
   K06059  ADAM17, TACE; disintegrin and metalloproteinase domain-containing protein 17
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-5
    ITGB1; integrin beta 1
     K06059 ADAM17, TACE; disintegrin and metalloproteinase domain-containing protein 17
Cellular antigens [BR:ko04090]
 Proteins
  K06059  CD156b, ADAM17; a disintegrin and metalloproteinase domain 17
BRITE hierarchy
Genes
HSA: 
6868(ADAM17)
PTR: 
459018(ADAM17)
PPS: 
100988650(ADAM17)
GGO: 
PON: 
100439426(ADAM17)
MCC: 
694429(ADAM17)
MCF: 
102116784(ADAM17)
MMU: 
11491(Adam17)
RNO: 
57027(Adam17)
CGE: 
100684971(Adam17)
HGL: 
101720924(Adam17)
TUP: 
102496316(ADAM17)
CFA: 
475662(ADAM17)
AML: 
100482770(ADAM17)
FCA: 
101089004(ADAM17)
PTG: 
102948618(ADAM17)
BTA: 
517541(ADAM17)
BOM: 
102279111(ADAM17)
PHD: 
102319953(ADAM17)
CHX: 
102188327(ADAM17)
OAS: 
101116815(ADAM17)
SSC: 
397343(ADAM17)
CFR: 
102508816(ADAM17)
BACU: 
103004501(ADAM17)
LVE: 
103086820(ADAM17)
ECB: 
100072496(ADAM17)
MYB: 
102256292(ADAM17)
MYD: 
102767398(ADAM17)
PALE: 
102894565(ADAM17)
MDO: 
100032069(ADAM17)
SHR: 
100926795(ADAM17)
OAA: 
100086345(ADAM17)
GGA: 
421931(ADAM17)
MGP: 
100549409(ADAM17)
TGU: 
100225922(ADAM17)
FAB: 
101814343(ADAM17)
PHI: 
102106429(ADAM17)
APLA: 
101794295(ADAM17)
FPG: 
101924106(ADAM17)
FCH: 
102055911(ADAM17)
CLV: 
102098173(ADAM17)
ASN: 
102373202(ADAM17)
AMJ: 
102560812(ADAM17)
PSS: 
102454376(ADAM17)
CMY: 
102933390(ADAM17)
ACS: 
100563907(adam17)
PBI: 
103060091(ADAM17)
XLA: 
733430(adam17)
XTR: 
100492947(adam17)
DRE: 
324142(adam17a) 560657(adam17b)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102367618(ADAM17)
CMK: 
103187122(adam17)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
551599(GB18818)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG16796(Cbr-adm-4)
LOA: 
TSP: 
SMM: 
HMG: 
TAD: 
MBR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Klein T, Bischoff R
  Title
Active metalloproteases of the A Disintegrin and Metalloprotease (ADAM) family: biological function and structure.
  Journal
J Proteome Res 10:17-33 (2011)

DBGET integrated database retrieval system