KEGG   ORTHOLOGY: K06255Help
Entry
K06255                      KO                                     

Name
HSPG2
Definition
heparan sulfate proteoglycan 2 (perlecan)
Pathway
ECM-receptor interaction
Hepatitis B
Proteoglycans in cancer
Disease
H00493  
Heparan sulfate proteoglycan gene defects
H01777  
Schwartz-Jampel syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
  Infectious diseases
   05161 Hepatitis B
    K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Cell adhesion molecules and their ligands [BR:ko04516]
 2. Integrin Family
  Beta1 integrins
   VLA-2
    ITGB1; integrin beta 1
     K06255 HSPG2; heparan sulfate proteoglycan 2 (perlecan)
 7. Others
  DAG1; dystroglycan 1
   K06255 HSPG2; heparan sulfate proteoglycan 2 (perlecan)
Proteoglycans [BR:ko00535]
 Extracellular matrix (ECM) proteoglycans
  Basement membrane proteoglycans
   K06255  HSPG2; heparan sulfate proteoglycan 2 (perlecan)
BRITE hierarchy
Genes
HSA: 
3339(HSPG2)
PTR: 
100613114(HSPG2)
PPS: 
100969025(HSPG2)
GGO: 
101138254(HSPG2)
PON: 
100446648(HSPG2)
NLE: 
100603335(HSPG2)
MCC: 
707213(HSPG2)
MCF: 
102145976(HSPG2)
CSAB: 
103225428(HSPG2)
RRO: 
104663240(HSPG2)
RBB: 
108538399(HSPG2)
CJC: 
100413695(HSPG2)
SBQ: 
101035920(HSPG2)
MMU: 
15530(Hspg2)
RNO: 
313641(Hspg2)
CGE: 
100689041(Hspg2)
NGI: 
103746433(Hspg2)
HGL: 
101700294(Hspg2)
CCAN: 
109694908(Hspg2)
OCU: 
100340334(HSPG2)
TUP: 
102493755(HSPG2)
CFA: 
403440(HSPG2)
AML: 
100467831(HSPG2)
UMR: 
103666798(HSPG2)
ORO: 
101366326(HSPG2)
FCA: 
101094520(HSPG2)
PTG: 
102954270(HSPG2)
AJU: 
106977608(HSPG2)
BTA: 
444872(HSPG2)
BOM: 
102271087(HSPG2)
BIU: 
PHD: 
CHX: 
102188640(HSPG2)
OAS: 
101122677(HSPG2)
SSC: 
100517288(HSPG2)
CFR: 
102522322(HSPG2)
CDK: 
105088891(HSPG2)
BACU: 
103016583(HSPG2)
LVE: 
103071665(HSPG2)
ECB: 
100071701(HSPG2)
EPZ: 
103558488(HSPG2)
EAI: 
106840047(HSPG2)
MYB: 
MYD: 
102756550(HSPG2)
HAI: 
109396746(HSPG2)
RSS: 
109435009(HSPG2)
PALE: 
102887886(HSPG2)
LAV: 
100668646(HSPG2)
TMU: 
MDO: 
100617792(HSPG2)
SHR: 
OAA: 
GGA: 
429806(HSPG2)
MGP: 
100549236(HSPG2)
CJO: 
107323300(HSPG2)
APLA: 
101796910(HSPG2)
ACYG: 
106048619(HSPG2)
GFR: 
102033967(HSPG2)
FAB: 
101809010(HSPG2)
PHI: 
102108967(HSPG2)
PMAJ: 
CCW: 
104698588(HSPG2)
FPG: 
101918976(HSPG2)
FCH: 
102055079(HSPG2)
CLV: 
106145640(HSPG2)
EGZ: 
104133199(HSPG2)
ASN: 
102377486(HSPG2)
AMJ: 
CMY: 
102942490(HSPG2)
CPIC: 
ACS: 
PVT: 
110073100(HSPG2)
PBI: 
103053870(HSPG2)
GJA: 
107111588(HSPG2)
XLA: 
108696836(hspg2.L)
XTR: 
100494785(hspg2)
NPR: 
108802213(HSPG2)
DRE: 
565429(hspg2)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
103021689(hspg2)
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
102217130(hspg2)
PRET: 
103467813(hspg2)
NFU: 
107390415(hspg2)
CSEM: 
103385274(hspg2)
LCF: 
108888875(hspg2)
HCQ: 
109520187(hspg2)
BPEC: 
110159404(hspg2)
SASA: 
ELS: 
105028690(hspg2)
SFM: 
108939266(hspg2)
LCM: 
102366028(HSPG2)
CMK: 
103181437(hspg2)
BFO: 
SPU: 
APLC: 
SKO: 
DPA: 
FCD: 
DPX: 
TUT: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
NVE: 
EPA: 
ADF: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1569102
  Authors
Murdoch AD, Dodge GR, Cohen I, Tuan RS, Iozzo RV
  Title
Primary structure of the human heparan sulfate proteoglycan from basement membrane (HSPG2/perlecan). A chimeric molecule with multiple domains homologous to the low density lipoprotein receptor, laminin, neural cell adhesion molecules, and epidermal growth factor.
  Journal
J Biol Chem 267:8544-57 (1992)
  Sequence
[hsa:3339]
Reference
  Authors
Whitelock JM, Melrose J, Iozzo RV
  Title
Diverse cell signaling events modulated by perlecan.
  Journal
Biochemistry 47:11174-83 (2008)
DOI:10.1021/bi8013938

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