KEGG   ORTHOLOGY: K06277Help
Entry
K06277                      KO                                     

Name
RAPGEF1, GRF2
Definition
Rap guanine nucleotide exchange factor 1
Pathway
Rap1 signaling pathway
Focal adhesion
Neurotrophin signaling pathway
Insulin signaling pathway
Renal cell carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 Cellular Processes
  Cell communication
   04510 Focal adhesion
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
  Nervous system
   04722 Neurotrophin signaling pathway
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
 Human Diseases
  Cancers
   05211 Renal cell carcinoma
    K06277  RAPGEF1, GRF2; Rap guanine nucleotide exchange factor 1
BRITE hierarchy
Genes
HSA: 
2889(RAPGEF1)
PTR: 
464812(RAPGEF1)
PPS: 
100972192(RAPGEF1)
GGO: 
101140063(RAPGEF1)
PON: 
100444262(RAPGEF1)
MCC: 
715272(RAPGEF1)
MCF: 
102137533(RAPGEF1)
MMU: 
107746(Rapgef1)
RNO: 
63881(Rapgef1)
CGE: 
HGL: 
101714387(Rapgef1)
TUP: 
102490444(RAPGEF1)
CFA: 
491286(RAPGEF1)
AML: 
FCA: 
101099507(RAPGEF1)
BTA: 
520454(RAPGEF1)
BOM: 
102286409(RAPGEF1)
PHD: 
102316375(RAPGEF1)
CHX: 
102176334(RAPGEF1)
SSC: 
100511735(RAPGEF1)
CFR: 
102521802(RAPGEF1)
ECB: 
100069527(RAPGEF1)
MYB: 
102249993(RAPGEF1)
MDO: 
SHR: 
100914252(RAPGEF1)
OAA: 
GGA: 
417173(RAPGEF1)
MGP: 
100538909(RAPGEF1)
TGU: 
100223502(RAPGEF1)
FAB: 
101819251(RAPGEF1)
PHI: 
102101609(RAPGEF1)
APLA: 
101796594(RAPGEF1)
FPG: 
101920279(RAPGEF1)
FCH: 
102051437(RAPGEF1)
CLV: 
102093050(RAPGEF1)
ASN: 
102376116(RAPGEF1)
XLA: 
444199(rapgef1)
XTR: 
733953(rapgef1)
DRE: 
394101(rapgef1b) 558635(rapgef1a)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102362033(RAPGEF1)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE16444(Dyak_C3G)
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
409856(GB18294)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CBR: 
BMY: 
LOA: 
TSP: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
DDI: 
DPP: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9266971
  Authors
van den Berghe N, Cool RH, Horn G, Wittinghofer A
  Title
Biochemical characterization of C3G: an exchange factor that discriminates between Rap1 and Rap2 and is not inhibited by Rap1A(S17N).
  Journal
Oncogene 15:845-50 (1997)

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