KEGG   ORTHOLOGY: K06463Help
Entry
K06463                      KO                                     

Name
FCGR3, CD16
Definition
low affinity immunoglobulin gamma Fc region receptor III
Pathway
Phagosome
Osteoclast differentiation
Natural killer cell mediated cytotoxicity
Leishmaniasis
Staphylococcus aureus infection
Tuberculosis
Systemic lupus erythematosus
Disease
H00080  
Systemic lupus erythematosus
H00090  
NK cell defects
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
  Development
   04380 Osteoclast differentiation
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
 Human Diseases
  Immune diseases
   05322 Systemic lupus erythematosus
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
  Infectious diseases
   05150 Staphylococcus aureus infection
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
   05152 Tuberculosis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
   05140 Leishmaniasis
    K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
Cellular antigens [BR:ko04090]
 Proteins
  K06463  CD16a, FCGR3A; Fc fragment of IgG, low affinity IIIa, receptor for (CD16)
  K06463  CD16b, FCGR3B; Fc fragment of IgG, low affinity IIIb, receptor for (CD16)
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Receptors
  K06463  FCGR3, CD16; low affinity immunoglobulin gamma Fc region receptor III
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
2214(FCGR3A) 2215(FCGR3B)
PTR: 
457457(FCGR3A) 745350(FCGR3A)
GGO: 
PON: 
100453994(FCGR3A)
NLE: 
101176357(FCGR3A)
MCC: 
720006(FCGR3)
MCF: 
102140945(FCGR3)
CSAB: 
RRO: 
CJC: 
SBQ: 
MMU: 
246256(Fcgr4)
RNO: 
116591(Fcgr2a) 304966(Fcgr3a)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
102499391(FCGR3B)
CFA: 
478984(FCGR3A)
AML: 
UMR: 
FCA: 
493677(FCGR3A)
PTG: 
BTA: 
281766(FCGR3A)
BOM: 
PHD: 
CHX: 
OAS: 
100192433(FCGR3A)
SSC: 
397684(FCGR3B)
CFR: 
BACU: 
LVE: 
ECB: 
100051526(CD16)
MYB: 
102247789(FCGR3B)
MYD: 
102754425(FCGR3A)
PALE: 
LAV: 
MDO: 
SHR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2526846
  Authors
Ravetch JV, Perussia B
  Title
Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions.
  Journal
J Exp Med 170:481-97 (1989)
  Sequence
[hsa:2214 2215]
Reference
  Authors
Jing Y, Ni Z, Wu J, Higgins L, Markowski TW, Kaufman DS, Walcheck B
  Title
Identification of an ADAM17 cleavage region in human CD16 (FcgammaRIII) and the engineering of a non-cleavable version of the receptor in NK cells.
  Journal
PLoS One 10:e0121788 (2015)

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