KEGG   ORTHOLOGY: K06470Help
Entry
K06470                      KO                                     

Name
CD28
Definition
CD28 antigen
Pathway
Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Intestinal immune network for IgA production
Type I diabetes mellitus
Measles
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Graft-versus-host disease
Viral myocarditis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06470  CD28; CD28 antigen
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K06470  CD28; CD28 antigen
   04672 Intestinal immune network for IgA production
    K06470  CD28; CD28 antigen
 Human Diseases
  Immune diseases
   05322 Systemic lupus erythematosus
    K06470  CD28; CD28 antigen
   05323 Rheumatoid arthritis
    K06470  CD28; CD28 antigen
   05320 Autoimmune thyroid disease
    K06470  CD28; CD28 antigen
   05330 Allograft rejection
    K06470  CD28; CD28 antigen
   05332 Graft-versus-host disease
    K06470  CD28; CD28 antigen
  Cardiovascular diseases
   05416 Viral myocarditis
    K06470  CD28; CD28 antigen
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K06470  CD28; CD28 antigen
  Infectious diseases
   05162 Measles
    K06470  CD28; CD28 antigen
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   B7-CD28 family
    CD80; CD80 antigen
     K06470 CD28; CD28 antigen
    CD86; CD86 antigen
     K06470 CD28; CD28 antigen
    ICOSLG, ICOSL; inducible T-cell co-stimulator ligand
     K06470 CD28; CD28 antigen
CD molecules [BR:ko04090]
 Proteins
  K06470  CD28; CD28 antigen (Tp44)
BRITE hierarchy
Genes
HSA: 
940(CD28)
PTR: 
470617(CD28)
PPS: 
100992093(CD28)
GGO: 
101127818(CD28)
PON: 
100450920(CD28)
NLE: 
100605914(CD28)
MCC: 
705313(CD28)
MCF: 
102146670(CD28)
CSAB: 
103217686(CD28)
RRO: 
104653590(CD28)
RBB: 
108537220(CD28)
CJC: 
100408536(CD28)
SBQ: 
101043195(CD28)
MMU: 
12487(Cd28)
RNO: 
25660(Cd28)
CGE: 
100769830(Cd28)
NGI: 
103744474(Cd28)
HGL: 
101699716(Cd28)
CCAN: 
109694003(Cd28)
OCU: 
100008998(CD28)
TUP: 
102483105(CD28)
CFA: 
403646(CD28)
AML: 
100477902(CD28)
UMR: 
103659772(CD28)
FCA: 
493802(CD28)
PTG: 
102954958(CD28)
AJU: 
106976711(CD28)
BTA: 
281050(CD28)
BOM: 
102282765(CD28)
BIU: 
109569809(CD28)
PHD: 
102319784(CD28)
CHX: 
102179142(CD28)
OAS: 
443480(CD28)
SSC: 
100515419(CD28)
CFR: 
102507848(CD28)
CDK: 
105098982(CD28)
BACU: 
103017404(CD28)
LVE: 
103071468(CD28)
ECB: 
100067829(CD28)
EPZ: 
103557389(CD28)
EAI: 
106828142(CD28)
MYB: 
102239113(CD28)
MYD: 
102773613(CD28)
HAI: 
109393950(CD28)
RSS: 
109445009(CD28)
PALE: 
102884019(CD28)
LAV: 
100661033(CD28)
MDO: 
100017932(CD28)
SHR: 
100921336(CD28)
OAA: 
100082570(CD28)
GGA: 
396249(CD28)
MGP: 
100126555(CD28)
CJO: 
107316578(CD28)
APLA: 
101803044(CD28)
ACYG: 
106030065(CD28)
TGU: 
100224836(CD28)
GFR: 
102040186(CD28)
FAB: 
101806823(CD28)
PHI: 
102114220(CD28)
CCW: 
104693812(CD28)
FPG: 
101923995(CD28)
FCH: 
102057651(CD28)
CLV: 
102087821(CD28)
AAM: 
106492392(CD28)
ASN: 
102377160(CD28)
AMJ: 
102568525(CD28)
PSS: 
102445987(CD28)
CMY: 
102947562(CD28)
CPIC: 
101945326(CD28)
ACS: 
100566176(cd28)
XLA: 
100036969(cd28.L) 108703047(cd28.S)
XTR: 
100126210(cd28)
NPR: 
108785030(CD28)
SRX: 
SANH: 
SGH: 
IPU: 
MZE: 
CSEM: 
103389879(cd28)
LCF: 
SASA: 
ELS: 
SFM: 
LCM: 
102357005(CD28)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2825196
  Authors
Aruffo A, Seed B
  Title
Molecular cloning of a CD28 cDNA by a high-efficiency COS cell expression system.
  Journal
Proc Natl Acad Sci U S A 84:8573-7 (1987)
DOI:10.1073/pnas.84.23.8573
  Sequence
[hsa:940]
Reference
PMID:8617933
  Authors
Blotta MH, Marshall JD, DeKruyff RH, Umetsu DT
  Title
Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis.
  Journal
J Immunol 156:3133-40 (1996)
Reference
  Authors
Chen L.
  Title
Co-inhibitory molecules of the B7-CD28 family in the control of T-cell immunity.
  Journal
Nat Rev Immunol 4:336-47 (2004)
DOI:10.1038/nri1349

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