KEGG   ORTHOLOGY: K06476Help
Entry
K06476                      KO                                     

Name
ITGA2B
Definition
integrin alpha 2B
Pathway
Rap1 signaling pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Pathways in cancer
Small cell lung cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
Disease
H00226  
Glanzmann thrombasthenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K06476  ITGA2B; integrin alpha 2B
   04151 PI3K-Akt signaling pathway
    K06476  ITGA2B; integrin alpha 2B
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06476  ITGA2B; integrin alpha 2B
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06476  ITGA2B; integrin alpha 2B
  Cellular commiunity
   04510 Focal adhesion
    K06476  ITGA2B; integrin alpha 2B
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06476  ITGA2B; integrin alpha 2B
   04611 Platelet activation
    K06476  ITGA2B; integrin alpha 2B
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06476  ITGA2B; integrin alpha 2B
   05222 Small cell lung cancer
    K06476  ITGA2B; integrin alpha 2B
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06476  ITGA2B; integrin alpha 2B
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06476  ITGA2B; integrin alpha 2B
   05414 Dilated cardiomyopathy (DCM)
    K06476  ITGA2B; integrin alpha 2B
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06476  ITGA2B; integrin alpha 2B
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06476  ITGA2B; integrin alpha 2B
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Others
   ICAM4; intercellular adhesion molecule 4
    alpha IIb beta 3
     K06476 ITGA2B; integrin alpha 2B
 5. Cadherin Family
  Classic Cadherins
   Vertebrate Type II classic cadherins
    CDH6; cadherin 6, type 2, K-cadherin
     alpha IIb  beta 3
      K06476 ITGA2B; integrin alpha 2B
 7. Others
  TNFSF5, CD40L; tumor necrosis factor (ligand) superfamily, member 5
   alpha IIb beta 3
    K06476 ITGA2B; integrin alpha 2B
Cellular antigens [BR:ko04090]
 Proteins
  K06476  CD41, ITGA2B; integrin, alpha 2b
BRITE hierarchy
Genes
HSA: 
3674(ITGA2B)
PTR: 
454730(ITGA2B)
PPS: 
100991197(ITGA2B)
GGO: 
101136113(ITGA2B)
PON: 
100452800(ITGA2B)
NLE: 
100601385(ITGA2B)
MCC: 
714955(ITGA2B)
MCF: 
102119413(ITGA2B)
RRO: 
104654717(ITGA2B)
CJC: 
100408748(ITGA2B)
MMU: 
16399(Itga2b)
RNO: 
685269(Itga2b)
CGE: 
100762814(Itga2b)
NGI: 
103738294(Itga2b)
HGL: 
101714332(Itga2b)
OCU: 
100008734(ITGA2B)
TUP: 
102493954(ITGA2B)
CFA: 
403789(ITGA2B)
AML: 
100484185(ITGA2B)
UMR: 
103665592(ITGA2B)
FCA: 
101100930(ITGA2B)
PTG: 
102951724(ITGA2B)
BTA: 
515011(ITGA2B)
BOM: 
102275560(ITGA2B)
PHD: 
102319110(ITGA2B)
CHX: 
102183451(ITGA2B)
OAS: 
101115719(ITGA2B)
SSC: 
397059(ITGA2B)
CFR: 
102521427(ITGA2B)
BACU: 
102999724(ITGA2B)
LVE: 
103075356(ITGA2B)
ECB: 
100009697(ITGA2B)
MYB: 
102252761(ITGA2B)
MYD: 
102767172(ITGA2B)
PALE: 
102883900(ITGA2B)
MDO: 
100023354(ITGA2B)
SHR: 
100932021(ITGA2B)
MGP: 
APLA: 
101792319(ITGA2B)
GFR: 
106632013(ITGA2B)
FAB: 
101814120(ITGA2B)
PHI: 
102101807(ITGA2B)
FPG: 
101913845(ITGA2B)
FCH: 
102046031(ITGA2B)
ASN: 
102372475(ITGA2B)
AMJ: 
102570562(ITGA2B)
CMY: 
102942431(ITGA2B)
ACS: 
100557235(itga2b)
PBI: 
103054796(ITGA2B)
GJA: 
XLA: 
100191022(itga2b.1) 495051(itga2b.2)
XTR: 
100158580(itga2b.1) 100495138(itga2b.2)
DRE: 
445380(itga2b)
XMA: 
102221313(itga2b)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2439501
  Authors
Poncz M, Eisman R, Heidenreich R, Silver SM, Vilaire G, Surrey S, Schwartz E, Bennett JS
  Title
Structure of the platelet membrane glycoprotein IIb. Homology to the alpha subunits of the vitronectin and fibronectin membrane receptors.
  Journal
J Biol Chem 262:8476-82 (1987)
  Sequence
[hsa:3674]
Reference
  Authors
Ye F, Petrich BG, Anekal P, Lefort CT, Kasirer-Friede A, Shattil SJ, Ruppert R, Moser M, Fassler R, Ginsberg MH
  Title
The mechanism of kindlin-mediated activation of integrin alphaIIbbeta3.
  Journal
Curr Biol 23:2288-95 (2013)

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