KEGG   ORTHOLOGY: K06478Help
Entry
K06478                      KO                                     

Name
PTPRC, CD45
Definition
receptor-type tyrosine-protein phosphatase C [EC:3.1.3.48]
Pathway
Cell adhesion molecules (CAMs)
T cell receptor signaling pathway
Fc gamma R-mediated phagocytosis
Primary immunodeficiency
Disease
H00091  
T-B+Severe combined immunodeficiencies (SCIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C
 Organismal Systems
  Immune system
   04660 T cell receptor signaling pathway
    K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C
   04666 Fc gamma R-mediated phagocytosis
    K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C
 Human Diseases
  Immune diseases
   05340 Primary immunodeficiency
    K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class I PTPs (Classical)
   Receptor PTPs
    K06478  PTPRC, CD45; receptor-type tyrosine-protein phosphatase C
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Immune system
   SIGLEC family
    CD22, SIGLEC2; CD22 antigen
     K06478 PTPRC, CD45; receptor-type tyrosine-protein phosphatase C
Cellular antigens [BR:ko04090]
 Proteins
  K06478  CD45, PTPRC; protein tyrosine phosphatase, receptor type, C
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
5788(PTPRC)
PTR: 
457607(PTPRC)
PPS: 
100990077(PTPRC)
GGO: 
101139739(PTPRC)
PON: 
100446144(PTPRC)
NLE: 
100605782(PTPRC)
MCC: 
712657(PTPRC)
MCF: 
102116047(PTPRC)
RRO: 
104658267(PTPRC)
CJC: 
100385061(PTPRC)
MMU: 
19264(Ptprc)
RNO: 
24699(Ptprc)
CGE: 
100761948(Ptprc)
NGI: 
103731886(Ptprc)
HGL: 
101710515(Ptprc)
OCU: 
100358807(PTPRC)
TUP: 
102477324(PTPRC)
CFA: 
490255(PTPRC)
AML: 
100474611(PTPRC)
UMR: 
103657689(PTPRC)
FCA: 
101097123(PTPRC)
PTG: 
102954348(PTPRC)
BTA: 
407152(PTPRC)
BOM: 
102286212(PTPRC)
PHD: 
102332865(PTPRC)
CHX: 
102173490(PTPRC)
OAS: 
101102917(PTPRC)
SSC: 
100522631(PTPRC) 396634(PTPRC)
CFR: 
102505369(PTPRC)
BACU: 
103016733(PTPRC)
LVE: 
103075494(PTPRC)
ECB: 
100061950(PTPRC)
MYB: 
102253269(PTPRC)
MYD: 
102758118(PTPRC)
PALE: 
102898377(PTPRC)
MDO: 
100026890(PTPRC)
SHR: 
100914830(PTPRC)
OAA: 
100074271(PTPRC)
GGA: 
386580(PTPRC)
MGP: 
100546661(PTPRC)
APLA: 
101800593(PTPRC)
TGU: 
100228668(PTPRC)
GFR: 
102035230(PTPRC)
FAB: 
101816312(PTPRC)
PHI: 
102108683(PTPRC)
CCW: 
104695412(PTPRC)
FPG: 
101920198(PTPRC)
FCH: 
102049881(PTPRC)
CLV: 
102089795(PTPRC)
ASN: 
102377892(PTPRC)
AMJ: 
102574965(PTPRC)
PSS: 
102450126(PTPRC)
CMY: 
102934899(PTPRC)
ACS: 
100563672(ptprc)
PBI: 
103054746(PTPRC)
XTR: 
100493434(ptprc)
DRE: 
559154(ptprc)
TRU: 
445949(ptprc)
MZE: 
OLA: 
101167945(ptprc)
XMA: 
102221561(ptprc)
LCM: 
102364296(PTPRC)
CMK: 
103174770(ptprc)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2824653
  Authors
Streuli M, Hall LR, Saga Y, Schlossman SF, Saito H
  Title
Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens.
  Journal
J Exp Med 166:1548-66 (1987)
  Sequence
[hsa:5788]
Reference
  Authors
Hermiston ML, Xu Z, Weiss A
  Title
CD45: a critical regulator of signaling thresholds in immune cells.
  Journal
Annu Rev Immunol 21:107-37 (2003)
Reference
PMID:2845400
  Authors
Charbonneau H, Tonks NK, Walsh KA, Fischer EH
  Title
The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine  phosphatase.
  Journal
Proc Natl Acad Sci U S A 85:7182-6 (1988)
  Sequence
[hsa:5788]

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