KEGG   ORTHOLOGY: K06481Help
Entry
K06481                      KO                                     

Name
ITGA2, CD49b
Definition
integrin alpha 2
Pathway
ko04145  Phagosome
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04611  Platelet activation
ko04640  Hematopoietic cell lineage
ko04810  Regulation of actin cytoskeleton
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05222  Small cell lung cancer
ko05410  Hypertrophic cardiomyopathy (HCM)
ko05412  Arrhythmogenic right ventricular cardiomyopathy (ARVC)
ko05414  Dilated cardiomyopathy (DCM)
Disease
H01235  Bleeding disorder platelet-type
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06481  ITGA2, CD49b; integrin alpha 2
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06481  ITGA2, CD49b; integrin alpha 2
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06481  ITGA2, CD49b; integrin alpha 2
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06481  ITGA2, CD49b; integrin alpha 2
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06481  ITGA2, CD49b; integrin alpha 2
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06481  ITGA2, CD49b; integrin alpha 2
   04611 Platelet activation
    K06481  ITGA2, CD49b; integrin alpha 2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06481  ITGA2, CD49b; integrin alpha 2
   05205 Proteoglycans in cancer
    K06481  ITGA2, CD49b; integrin alpha 2
   05222 Small cell lung cancer
    K06481  ITGA2, CD49b; integrin alpha 2
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06481  ITGA2, CD49b; integrin alpha 2
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06481  ITGA2, CD49b; integrin alpha 2
   05414 Dilated cardiomyopathy (DCM)
    K06481  ITGA2, CD49b; integrin alpha 2
  Infectious diseases
   05165 Human papillomavirus infection
    K06481  ITGA2, CD49b; integrin alpha 2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K06481  ITGA2, CD49b; integrin alpha 2
  Exosomal proteins of bladder cancer cells
   K06481  ITGA2, CD49b; integrin alpha 2
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06481  ITGA2, CD49b; integrin alpha 2
CD molecules [BR:ko04090]
 Proteins
  K06481  CD49b, ITGA2; integrin, alpha 2
BRITE hierarchy
Genes
HSA: 3673(ITGA2)
PTR: 471550(ITGA2)
PPS: 100978441(ITGA2)
GGO: 101127372(ITGA2)
NLE: 100588661(ITGA2)
MCC: 703572(ITGA2)
MCF: 102133302(ITGA2)
CSAB: 103221285(ITGA2)
RRO: 104672477(ITGA2)
RBB: 108522903(ITGA2)
CJC: 100403636(ITGA2)
SBQ: 101041311(ITGA2)
MMU: 16398(Itga2)
RNO: 170921(Itga2)
CGE: 100774579(Itga2)
NGI: 103734059(Itga2)
HGL: 101702532(Itga2)
CCAN: 109696854(Itga2)
OCU: 100101621(ITGA2)
TUP: 102476022(ITGA2)
CFA: 489208(ITGA2)
AML: 100476403(ITGA2)
UMR: 103664633(ITGA2)
ORO: 101375601(ITGA2)
FCA: 101090237(ITGA2)
PTG: 102958888(ITGA2)
AJU: 106976293(ITGA2)
BTA: 281872(ITGA2)
BOM: 102281399(ITGA2)
BIU: 109574862(ITGA2)
PHD: 102317742(ITGA2)
CHX: 102172198(ITGA2)
OAS: 101119848(ITGA2)
SSC: 397483(ITGA2)
CFR: 102522915(ITGA2)
CDK: 105084263(ITGA2)
BACU: 103016586(ITGA2)
LVE: 103085988(ITGA2)
OOR: 101276348 101282448(ITGA2)
ECB: 100063367(ITGA2)
EPZ: 103558080(ITGA2)
EAI: 106843345(ITGA2)
MYB: 102244336(ITGA2)
MYD: 102760052(ITGA2)
HAI: 109382125(ITGA2)
RSS: 109449706(ITGA2)
PALE: 102897185(ITGA2)
LAV: 100674705(ITGA2)
TMU: 101358848
MDO: 100031498(ITGA2)
GGA: 100857227(ITGA2)
CJO: 107305978(ITGA2)
APLA: 101802508(ITGA2)
ACYG: 106035652(ITGA2)
TGU: 100221336(ITGA2)
GFR: 102038455(ITGA2)
FAB: 101818939(ITGA2)
PHI: 102108289(ITGA2)
PMAJ: 107216191(ITGA2)
CCW: 104686657(ITGA2)
FPG: 101915932(ITGA2)
FCH: 102056680(ITGA2)
CLV: 102091733(ITGA2)
EGZ: 104131629(ITGA2)
AAM: 106489819 106499982(ITGA2)
ASN: 102382534(ITGA2)
AMJ: 102562789(ITGA2)
PSS: 102452981(ITGA2)
CMY: 102938513(ITGA2)
CPIC: 101948248(ITGA2)
ACS: 100564306(itga2)
PVT: 110073896(ITGA2)
PBI: 103048386(ITGA2)
GJA: 107116970(ITGA2)
XLA: 373743(itga2.L)
XTR: 100492714(itga2)
NPR: 108799979(ITGA2)
DRE: 100536533(itga2.2)
IPU: 108276854(itga2)
AMEX: 103040237(itga2)
TRU: 101065018(itga2)
LCO: 104922975(itga2)
NCC: 104961568(itga2)
MZE: 101463902(itga2)
OLA: 101174027(itga2)
XMA: 102225347(itga2)
PRET: 103469997(itga2)
NFU: 107394288(itga2)
CSEM: 103397740(itga2)
LCF: 108896084(itga2)
HCQ: 109526498(itga2)
BPEC: 110172107(itga2)
ELS: 105014941(itga2)
SFM: 108925115(itga2)
LCM: 102355132(ITGA2)
CMK: 103177840(itga2)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2545729
  Authors
Takada Y, Hemler ME
  Title
The primary structure of the VLA-2/collagen receptor alpha 2 subunit (platelet GPIa): homology to other integrins and the presence of a possible collagen-binding domain.
  Journal
J Cell Biol 109:397-407 (1989)
DOI:10.1083/jcb.109.1.397
  Sequence
[hsa:3673]
Reference
  Authors
Graham KL, Halasz P, Tan Y, Hewish MJ, Takada Y, Mackow ER, Robinson MK, Coulson BS
  Title
Integrin-using rotaviruses bind alpha2beta1 integrin alpha2 I domain via VP4 DGE sequence and recognize alphaXbeta2 and alphaVbeta3 by using VP7 during cell entry.
  Journal
J Virol 77:9969-78 (2003)
DOI:10.1128/JVI.77.18.9969-9978.2003

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