KEGG   ORTHOLOGY: K06483Help
Entry
K06483                      KO                                     
Name
ITGA4
Definition
integrin alpha 4
Pathway
PI3K-Akt signaling pathway
Focal adhesion
ECM-receptor interaction
Cell adhesion molecules (CAMs)
Hematopoietic cell lineage
Leukocyte transendothelial migration
Intestinal immune network for IgA production
Regulation of actin cytoskeleton
Leishmaniasis
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04151 PI3K-Akt signaling pathway
    K06483  ITGA4; integrin alpha 4
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06483  ITGA4; integrin alpha 4
   04514 Cell adhesion molecules (CAMs)
    K06483  ITGA4; integrin alpha 4
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06483  ITGA4; integrin alpha 4
  Cell communication
   04510 Focal adhesion
    K06483  ITGA4; integrin alpha 4
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06483  ITGA4; integrin alpha 4
   04670 Leukocyte transendothelial migration
    K06483  ITGA4; integrin alpha 4
   04672 Intestinal immune network for IgA production
    K06483  ITGA4; integrin alpha 4
 Human Diseases
  Cardiovascular diseases
   05410 Hypertrophic cardiomyopathy (HCM)
    K06483  ITGA4; integrin alpha 4
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06483  ITGA4; integrin alpha 4
   05414 Dilated cardiomyopathy (DCM)
    K06483  ITGA4; integrin alpha 4
  Infectious diseases
   05140 Leishmaniasis
    K06483  ITGA4; integrin alpha 4
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    NRCAM; neuronal cell adhesion molecule
     VLA-4
      K06483 ITGA4; integrin alpha 4
  Others
   VCAM1; vascular cell adhesion molecule 1
    VLA-4
     K06483 ITGA4; integrin alpha 4
    alpha 4 beta7
     K06483 ITGA4; integrin alpha 4
   MADCAM1; mucosal vascular addressin cell adhesion molecule 1
    alpha 4 beta7
     K06483 ITGA4; integrin alpha 4
   LU; Lutheran blood group glycoprotein
    VLA-4
     K06483 ITGA4; integrin alpha 4
   JAM2; junctional adhesion molecule 2
    VLA-4
     K06483 ITGA4; integrin alpha 4
Cellular antigens [BR:ko04090]
 Proteins
  K06483  CD49d, ITGA4; integrin, alpha 4
BRITE hierarchy
Genes
HSA: 
3676(ITGA4)
PTR: 
470596(ITGA4)
PPS: 
100983460(ITGA4)
GGO: 
PON: 
100441139(ITGA4)
MCC: 
704745(ITGA4)
MMU: 
16401(Itga4)
RNO: 
311144(Itga4)
CFA: 
488429(ITGA4)
AML: 
100464670(ITGA4)
FCA: 
101081745(ITGA4)
BTA: 
282882(ITGA4)
SSC: 
100521477(ITGA4)
ECB: 
100067886(ITGA4)
MDO: 
100027449(ITGA4)
SHR: 
100923854(ITGA4)
OAA: 
100085588(ITGA4)
GGA: 
424121(ITGA4)
TGU: 
100219853(ITGA4)
ACS: 
100552809
XLA: 
397839(itga4)
XTR: 
100487924
DRE: 
100331333
TRU: 
101067986
OLA: 
101166094
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
van der Flier A, Sonnenberg A.
  Title
Function and interactions of integrins.
  Journal
Cell Tissue Res 305:285-98 (2001)
Reference
  Authors
Barczyk M, Carracedo S, Gullberg D
  Title
Integrins.
  Journal
Cell Tissue Res 339:269-80 (2010)
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