KEGG   ORTHOLOGY: K06493Help
Entry
K06493                      KO                                     

Name
ITGB3, CD61
Definition
integrin beta 3
Pathway
Rap1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Osteoclast differentiation
Focal adhesion
ECM-receptor interaction
Platelet activation
Hematopoietic cell lineage
Regulation of actin cytoskeleton
Thyroid hormone signaling pathway
Proteoglycans in cancer
MicroRNAs in cancer
Hypertrophic cardiomyopathy (HCM)
Arrhythmogenic right ventricular cardiomyopathy (ARVC)
Dilated cardiomyopathy
Fluid shear stress and atherosclerosis
Disease
H00083  
Allograft rejection
H00226  
Glanzmann thrombasthenia
H01740  
Macrothrombocytopenia
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K06493  ITGB3, CD61; integrin beta 3
   04151 PI3K-Akt signaling pathway
    K06493  ITGB3, CD61; integrin beta 3
  Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06493  ITGB3, CD61; integrin beta 3
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06493  ITGB3, CD61; integrin beta 3
  Cellular community - eukaryotes
   04510 Focal adhesion
    K06493  ITGB3, CD61; integrin beta 3
  Cell motility
   04810 Regulation of actin cytoskeleton
    K06493  ITGB3, CD61; integrin beta 3
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06493  ITGB3, CD61; integrin beta 3
   04611 Platelet activation
    K06493  ITGB3, CD61; integrin beta 3
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K06493  ITGB3, CD61; integrin beta 3
  Development
   04380 Osteoclast differentiation
    K06493  ITGB3, CD61; integrin beta 3
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K06493  ITGB3, CD61; integrin beta 3
   05205 Proteoglycans in cancer
    K06493  ITGB3, CD61; integrin beta 3
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K06493  ITGB3, CD61; integrin beta 3
   05410 Hypertrophic cardiomyopathy (HCM)
    K06493  ITGB3, CD61; integrin beta 3
   05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    K06493  ITGB3, CD61; integrin beta 3
   05414 Dilated cardiomyopathy (DCM)
    K06493  ITGB3, CD61; integrin beta 3
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K06493  ITGB3, CD61; integrin beta 3
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06493  ITGB3, CD61; integrin beta 3
Cell adhesion molecules and their ligands [BR:ko04516]
 1. Immunoglobulin Superfamily
  Neural system
   6/5 subfamily
    L1CAM; L1 cell adhesion molecule
     VNR
      K06493 ITGB3, CD61; integrin beta 3
   N/0 subfamily
    THY1, CD90; Thy-1 cell surface antigen
     VNR
      K06493 ITGB3, CD61; integrin beta 3
  Others
   PECAM1, CD31; platelet/endothelial cell adhesion molecule
    VNR
     K06493 ITGB3, CD61; integrin beta 3
   ICAM4; intercellular adhesion molecule 4
    VNR
     K06493 ITGB3, CD61; integrin beta 3
    alpha IIb beta 3
     K06493 ITGB3, CD61; integrin beta 3
 5. Cadherin Family
  Classic Cadherins
   Vertebrate Type II classic cadherins
    CDH6; cadherin 6, type 2, K-cadherin
     alpha IIb  beta 3
      K06493 ITGB3, CD61; integrin beta 3
 7. Others
  TNFSF5, CD40L; tumor necrosis factor (ligand) superfamily, member 5
   alpha IIb beta 3
    K06493 ITGB3, CD61; integrin beta 3
  SDC1; syndecan 1
   VNR
    K06493 ITGB3, CD61; integrin beta 3
Cellular antigens [BR:ko04090]
 Proteins
  K06493  CD61, ITGB3; integrin, beta 3
BRITE hierarchy
Genes
HSA: 
3690(ITGB3)
PTR: 
468295(ITGB3)
PPS: 
100974497(ITGB3)
GGO: 
101149719(ITGB3)
PON: 
100445345(ITGB3)
NLE: 
100593791(ITGB3)
MCC: 
717379(ITGB3)
MCF: 
102117791(ITGB3)
CSAB: 
103243277(ITGB3)
RRO: 
104662513(ITGB3)
CJC: 
100386042(ITGB3)
SBQ: 
101049562(ITGB3)
MMU: 
16416(Itgb3)
RNO: 
29302(Itgb3)
CGE: 
100775048(Itgb3)
NGI: 
103724762(Itgb3)
HGL: 
101715910(Itgb3)
OCU: 
100008735(ITGB3)
TUP: 
102486101(ITGB3)
CFA: 
403788(ITGB3)
AML: 
100476256(ITGB3)
UMR: 
103665892(ITGB3)
FCA: 
101092159(ITGB3)
PTG: 
102963673(ITGB3)
BTA: 
282642(ITGB3)
BOM: 
102268918(ITGB3)
PHD: 
102334258(ITGB3)
CHX: 
102169417(ITGB3)
OAS: 
100423047(ITGB3)
SSC: 
397063(ITGB3)
CFR: 
102512014(ITGB3)
BACU: 
103005345(ITGB3)
LVE: 
103070292(ITGB3)
ECB: 
100009709(ITGB3)
MYB: 
102242014(ITGB3)
MYD: 
102761706(ITGB3)
PALE: 
102881894(ITGB3)
LAV: 
100660405(ITGB3)
MDO: 
100025359(ITGB3)
SHR: 
100920734(ITGB3)
OAA: 
GGA: 
374209(ITGB3)
MGP: 
100540307(ITGB3)
CJO: 
107325258(ITGB3)
APLA: 
101803666(ITGB3)
TGU: 
100226539(ITGB3)
GFR: 
102043377(ITGB3)
FAB: 
101806454(ITGB3)
PHI: 
102114571(ITGB3)
CCW: 
104698490(ITGB3)
FPG: 
101924792(ITGB3)
FCH: 
102048772(ITGB3)
CLV: 
102089259(ITGB3)
AAM: 
ASN: 
102372699(ITGB3)
AMJ: 
102570288(ITGB3)
PSS: 
102444998(ITGB3)
CMY: 
ACS: 
PBI: 
103060352(ITGB3)
GJA: 
XLA: 
397699(itgb3.L)
XTR: 
100498495(itgb3)
DRE: 
100001836(itgb3b)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102349935(ITGB3)
CMK: 
103187732(itgb3)
CRG: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3494014
  Authors
Fitzgerald LA, Steiner B, Rall SC Jr, Lo SS, Phillips DR
  Title
Protein sequence of endothelial glycoprotein IIIa derived from a cDNA clone. Identity with platelet glycoprotein IIIa and similarity to "integrin".
  Journal
J Biol Chem 262:3936-9 (1987)
  Sequence
[hsa:3690]
Reference
PMID:9195946
  Authors
Kumar CS, James IE, Wong A, Mwangi V, Feild JA, Nuthulaganti P, Connor JR, Eichman C, Ali F, Hwang SM, Rieman DJ, Drake FH, Gowen M
  Title
Cloning and characterization of a novel integrin beta3 subunit.
  Journal
J Biol Chem 272:16390-7 (1997)

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