KEGG   ORTHOLOGY: K06618Help
Entry
K06618                      KO                                     

Name
RB1
Definition
retinoblastoma-associated protein
Pathway
Endocrine resistance
Cell cycle
Cellular senescence
Hepatitis B
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Pancreatic cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Module
M00692  
Cell cycle - G1/S transition
Disease
H00004  
Chronic myeloid leukemia (CML)
H00013  
Small cell lung cancer
H00017  
Esophageal cancer
H00022  
Bladder cancer
H00031  
Breast cancer
H00036  
Osteosarcoma
H00042  
Glioma
H00048  
Hepatocellular carcinoma
H01513  
Retinoblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06618  RB1; retinoblastoma-associated protein
   04218 Cellular senescence
    K06618  RB1; retinoblastoma-associated protein
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06618  RB1; retinoblastoma-associated protein
   05203 Viral carcinogenesis
    K06618  RB1; retinoblastoma-associated protein
   05212 Pancreatic cancer
    K06618  RB1; retinoblastoma-associated protein
   05214 Glioma
    K06618  RB1; retinoblastoma-associated protein
   05220 Chronic myeloid leukemia
    K06618  RB1; retinoblastoma-associated protein
   05218 Melanoma
    K06618  RB1; retinoblastoma-associated protein
   05219 Bladder cancer
    K06618  RB1; retinoblastoma-associated protein
   05215 Prostate cancer
    K06618  RB1; retinoblastoma-associated protein
   05224 Breast cancer
    K06618  RB1; retinoblastoma-associated protein
   05222 Small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
   05223 Non-small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
  Infectious diseases
   05166 HTLV-I infection
    K06618  RB1; retinoblastoma-associated protein
   05161 Hepatitis B
    K06618  RB1; retinoblastoma-associated protein
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K06618  RB1; retinoblastoma-associated protein
   05169 Epstein-Barr virus infection
    K06618  RB1; retinoblastoma-associated protein
   05165 Human papillomavirus infection
    K06618  RB1; retinoblastoma-associated protein
  Drug resistance
   01522 Endocrine resistance
    K06618  RB1; retinoblastoma-associated protein
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00692  Cell cycle - G1/S transition
     K06618  RB1; retinoblastoma-associated protein
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06618  RB1; retinoblastoma-associated protein
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Other transcription factors
   Pocket domain Rb
    K06618  RB1; retinoblastoma-associated protein
BRITE hierarchy
Genes
HSA: 
5925(RB1)
PTR: 
452715(RB1)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
704871(RB1)
MCF: 
CSAB: 
RRO: 
RBB: 
108530701(RB1)
CJC: 
100397928(RB1)
SBQ: 
101038309(RB1)
MMU: 
19645(Rb1)
RNO: 
24708(Rb1)
CGE: 
100752928(Rb1)
NGI: 
103726779(Rb1)
HGL: 
101703701(Rb1)
CCAN: 
109691094(Rb1)
OCU: 
100357431(RB1)
TUP: 
102499507(RB1)
CFA: 
476915(RB1)
AML: 
100477714(RB1)
UMR: 
103677688(RB1)
FCA: 
101101356(RB1)
PTG: 
102952365(RB1)
AJU: 
106971960(RB1)
BTA: 
534712(RB1)
BOM: 
102267169(RB1)
BIU: 
109566987(RB1)
PHD: 
102318268(RB1)
CHX: 
102183886(RB1)
OAS: 
100144755(RB1)
SSC: 
100151828(RB1)
CFR: 
102516870(RB1)
CDK: 
105101803(RB1)
BACU: 
103013752(RB1)
LVE: 
103072166(RB1)
ECB: 
100057080(RB1)
EPZ: 
103549440(RB1)
EAI: 
106829635(RB1)
MYB: 
102251785(RB1)
MYD: 
102766251(RB1)
HAI: 
109387138(RB1)
RSS: 
109456051(RB1)
PALE: 
102893019(RB1)
LAV: 
100673196
MDO: 
100022630(RB1)
SHR: 
100914196(RB1)
OAA: 
100083537(RB1)
GGA: 
386582(RB1)
MGP: 
100549197(RB1) 104917517
CJO: 
107308151(RB1)
APLA: 
101793414(RB1)
ACYG: 
106035039(RB1)
TGU: 
100217687(RB1)
GFR: 
102036868(RB1)
FAB: 
101806985(RB1)
PHI: 
102105165(RB1)
CCW: 
104690005(RB1)
FPG: 
101918471(RB1)
FCH: 
102054877(RB1)
CLV: 
102084576(RB1)
AAM: 
106489167(RB1)
ASN: 
102379703(RB1)
AMJ: 
102564411(RB1)
PSS: 
102445665(RB1)
CMY: 
102937814(RB1)
CPIC: 
101930889(RB1)
ACS: 
100567638(rb1)
PBI: 
103062466(RB1)
GJA: 
107112871(RB1)
XLA: 
108709804(rb1.S)
XTR: 
100493114(rb1)
NPR: 
108792451(RB1)
DRE: 
777733(rb1)
SRX: 
107718950 107731452
SANH: 
107681157 107703523
SGH: 
107548180 107551603
IPU: 
108279123(rb1)
TRU: 
101069848(rb1)
TNG: 
GSTEN00022163G001
LCO: 
104919743(rb1)
NCC: 
104954675(rb1)
MZE: 
101480728(rb1)
OLA: 
100049519(rb1)
XMA: 
102230233(rb1)
CSEM: 
103395441(rb1)
LCF: 
108893878(rb1)
SASA: 
100380330(rb1)
ELS: 
105023905(rb1)
SFM: 
108934475(rb1)
LCM: 
102347219 102366565(RB1)
CMK: 
103177409(rb1)
BFO: 
BRAFLDRAFT_135823
SPU: 
585399
SKO: 
102809503 102810253
LGI: 
LOTGIDRAFT_220664
CRG: 
105341190
OBI: 
106877521
LAK: 
106159874 106159875 106169307
ADF: 
107336100
TAD: 
TRIADDRAFT_60210
CME: 
CYME_CMT038C
TET: 
TTHERM_00439030
PTM: 
GSPATT00022277001
PIF: 
PITG_16462
PSOJ: 
PHYSODRAFT_354183
SPAR: 
SPRG_08426
EHX: 
EMIHUDRAFT_462234
NGR: 
NAEGRDRAFT_80903
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1756735
  Authors
Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E
  Title
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
  Journal
EMBO J 10:4279-90 (1991)
  Sequence
[hsa:5925]
Reference
  Authors
Ren S, Rollins BJ
  Title
Cyclin C/cdk3 promotes Rb-dependent G0 exit.
  Journal
Cell 117:239-51 (2004)
DOI:10.1016/S0092-8674(04)00300-9
  Sequence
[hsa:5925]
Reference
PMID:3823889
  Authors
Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY
  Title
Human retinoblastoma susceptibility gene: cloning, identification, and sequence.
  Journal
Science 235:1394-9 (1987)
DOI:10.1126/science.3823889
  Sequence
[hsa:5925]
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