KEGG   ORTHOLOGY: K06618Help
Entry
K06618                      KO                                     

Name
RB1
Definition
retinoblastoma-associated protein
Pathway
ko01522  Endocrine resistance
ko04110  Cell cycle
ko04218  Cellular senescence
ko04934  Cushing's syndrome
ko05161  Hepatitis B
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05212  Pancreatic cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Module
M00692  Cell cycle - G1/S transition
Disease
H00004  Chronic myeloid leukemia (CML)
H00013  Small cell lung cancer
H00017  Esophageal cancer
H00022  Bladder cancer
H00036  Osteosarcoma
H00042  Glioma
H00048  Hepatocellular carcinoma
H01513  Retinoblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06618  RB1; retinoblastoma-associated protein
   04218 Cellular senescence
    K06618  RB1; retinoblastoma-associated protein
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06618  RB1; retinoblastoma-associated protein
   05203 Viral carcinogenesis
    K06618  RB1; retinoblastoma-associated protein
   05212 Pancreatic cancer
    K06618  RB1; retinoblastoma-associated protein
   05225 Hepatocellular carcinoma
    K06618  RB1; retinoblastoma-associated protein
   05226 Gastric cancer
    K06618  RB1; retinoblastoma-associated protein
   05214 Glioma
    K06618  RB1; retinoblastoma-associated protein
   05220 Chronic myeloid leukemia
    K06618  RB1; retinoblastoma-associated protein
   05218 Melanoma
    K06618  RB1; retinoblastoma-associated protein
   05219 Bladder cancer
    K06618  RB1; retinoblastoma-associated protein
   05215 Prostate cancer
    K06618  RB1; retinoblastoma-associated protein
   05224 Breast cancer
    K06618  RB1; retinoblastoma-associated protein
   05222 Small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
   05223 Non-small cell lung cancer
    K06618  RB1; retinoblastoma-associated protein
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K06618  RB1; retinoblastoma-associated protein
  Infectious diseases
   05166 HTLV-I infection
    K06618  RB1; retinoblastoma-associated protein
   05161 Hepatitis B
    K06618  RB1; retinoblastoma-associated protein
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K06618  RB1; retinoblastoma-associated protein
   05169 Epstein-Barr virus infection
    K06618  RB1; retinoblastoma-associated protein
   05165 Human papillomavirus infection
    K06618  RB1; retinoblastoma-associated protein
  Drug resistance
   01522 Endocrine resistance
    K06618  RB1; retinoblastoma-associated protein
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00692  Cell cycle - G1/S transition
     K06618  RB1; retinoblastoma-associated protein
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K06618  RB1; retinoblastoma-associated protein
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Other transcription factors
   Pocket domain Rb
    K06618  RB1; retinoblastoma-associated protein
BRITE hierarchy
Genes
HSA: 5925(RB1)
PTR: 452715(RB1)
PPS: 100973837(RB1)
GGO: 101133237(RB1) 101134294
PON: 100462155(RB1)
NLE: 100588629(RB1)
MCC: 704871(RB1)
MCF: 102145859(RB1)
CSAB: 103214406(RB1)
RRO: 104662760(RB1)
RBB: 108530701(RB1)
CJC: 100397928(RB1)
SBQ: 101038309(RB1)
MMU: 19645(Rb1)
RNO: 24708(Rb1)
CGE: 100752928(Rb1)
NGI: 103726779(Rb1)
HGL: 101703701(Rb1)
CCAN: 109691094(Rb1)
OCU: 100357431(RB1)
TUP: 102499507(RB1)
CFA: 476915(RB1)
AML: 100477714(RB1)
UMR: 103677688(RB1)
ORO: 101386367(RB1)
FCA: 101101356(RB1)
PTG: 102952365(RB1)
AJU: 106971960(RB1)
BTA: 534712(RB1)
BOM: 102267169(RB1)
BIU: 109566987(RB1)
PHD: 102318268(RB1)
CHX: 102183886(RB1)
OAS: 100144755(RB1)
SSC: 100151828(RB1)
CFR: 102516870(RB1)
CDK: 105101803(RB1)
BACU: 103013752(RB1)
LVE: 103072166(RB1)
OOR: 101272870(RB1)
ECB: 100057080(RB1)
EPZ: 103549440(RB1)
EAI: 106829635(RB1)
MYB: 102251785(RB1)
MYD: 102766251(RB1)
HAI: 109387138(RB1)
RSS: 109456051(RB1)
PALE: 102893019(RB1)
LAV: 100673196(RB1)
TMU: 101355952
MDO: 100022630(RB1)
SHR: 100914196(RB1)
OAA: 100083537(RB1)
GGA: 386582(RB1)
MGP: 100549197(RB1) 104917517
CJO: 107308151(RB1)
APLA: 101793414(RB1)
ACYG: 106035039(RB1)
TGU: 100217687(RB1)
GFR: 102036868(RB1)
FAB: 101806985(RB1)
PHI: 102105165(RB1)
PMAJ: 107203084(RB1)
CCW: 104690005(RB1)
FPG: 101918471(RB1)
FCH: 102054877(RB1)
CLV: 102084576(RB1)
EGZ: 104131621(RB1)
AAM: 106489167(RB1)
ASN: 102379703(RB1)
AMJ: 102564411(RB1)
PSS: 102445665(RB1)
CMY: 102937814(RB1)
CPIC: 101930889(RB1)
ACS: 100567638(rb1)
PVT: 110091007(RB1)
PBI: 103062466(RB1)
GJA: 107112871(RB1)
XLA: 108709804(rb1.S)
XTR: 100493114(rb1)
NPR: 108792451(RB1)
DRE: 777733(rb1)
IPU: 108279123(rb1)
AMEX: 103040648(rb1)
TRU: 101069848(rb1)
LCO: 104919743(rb1)
NCC: 104954675(rb1)
MZE: 101480728(rb1)
OLA: 100049519(rb1)
XMA: 102230233(rb1)
NFU: 107386518(rb1)
CSEM: 103395441(rb1)
LCF: 108893878(rb1)
HCQ: 109512505(rb1)
BPEC: 110168135(rb1)
SASA: 100380330(rb1)
ELS: 105023905(rb1)
SFM: 108934475(rb1)
LCM: 102347219 102366565(RB1)
CMK: 103177409(rb1)
SPU: 585399
APLC: 110981738
CRG: 105341190
MYI: 110447895
OBI: 106877521
ADF: 107336100
DFA: DFA_11907(rblA)
SPAR: SPRG_08426
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1756735
  Authors
Lees JA, Buchkovich KJ, Marshak DR, Anderson CW, Harlow E
  Title
The retinoblastoma protein is phosphorylated on multiple sites by human cdc2.
  Journal
EMBO J 10:4279-90 (1991)
  Sequence
[hsa:5925]
Reference
  Authors
Ren S, Rollins BJ
  Title
Cyclin C/cdk3 promotes Rb-dependent G0 exit.
  Journal
Cell 117:239-51 (2004)
DOI:10.1016/S0092-8674(04)00300-9
  Sequence
[hsa:5925]
Reference
PMID:3823889
  Authors
Lee WH, Bookstein R, Hong F, Young LJ, Shew JY, Lee EY
  Title
Human retinoblastoma susceptibility gene: cloning, identification, and sequence.
  Journal
Science 235:1394-9 (1987)
DOI:10.1126/science.3823889
  Sequence
[hsa:5925]

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