KEGG   ORTHOLOGY: K06640Help
Entry
K06640                      KO                                     

Name
ATR
Definition
serine/threonine-protein kinase ATR [EC:2.7.11.1]
Pathway
ko03460  Fanconi anemia pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04214  Apoptosis - fly
ko04218  Cellular senescence
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
Module
M00691  DNA damage-induced cell cycle checkpoints
Disease
H00037  Alveolar rhabdomyosarcoma
H00992  Seckel syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03460 Fanconi anemia pathway
    K06640  ATR; serine/threonine-protein kinase ATR
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06640  ATR; serine/threonine-protein kinase ATR
   04214 Apoptosis - fly
    K06640  ATR; serine/threonine-protein kinase ATR
   04115 p53 signaling pathway
    K06640  ATR; serine/threonine-protein kinase ATR
   04218 Cellular senescence
    K06640  ATR; serine/threonine-protein kinase ATR
 Human Diseases
  Infectious diseases
   05166 HTLV-I infection
    K06640  ATR; serine/threonine-protein kinase ATR
   05165 Human papillomavirus infection
    K06640  ATR; serine/threonine-protein kinase ATR
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K06640  ATR; serine/threonine-protein kinase ATR
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06640  ATR; serine/threonine-protein kinase ATR
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   K06640  ATR; serine/threonine-protein kinase ATR
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K06640  ATR; serine/threonine-protein kinase ATR
BRITE hierarchy
Genes
HSA: 545(ATR)
PTR: 460745(ATR)
PPS: 100975153(ATR)
GGO: 101148147(ATR)
PON: 100454403(ATR)
NLE: 100598462(ATR)
MCC: 714443(ATR)
MCF: 101926636(ATR)
CSAB: 103241557(ATR)
RRO: 104682194(ATR)
RBB: 108535876(ATR)
CJC: 100412321(ATR)
SBQ: 101043200(ATR)
MMU: 245000(Atr)
RNO: 685055(Atr)
CGE: 100766256(Atr)
NGI: 103752518(Atr)
HGL: 101701996(Atr)
CCAN: 109699835(Atr)
OCU: 100359062(ATR)
TUP: 102482195(ATR)
CFA: 100856315(ATR)
AML: 100464897(ATR)
UMR: 103678381(ATR)
ORO: 101370393(ATR)
FCA: 101088023(ATR)
PTG: 102972858(ATR)
AJU: 106982261(ATR)
BTA: 504869(ATR)
BOM: 102268491(ATR)
BIU: 109559556(ATR)
PHD: 102327558(ATR)
CHX: 102178489(ATR)
OAS: 101106566(ATR)
SSC: 100516227(ATR)
CFR: 102516904(ATR)
CDK: 105086328(ATR)
BACU: 103017117(ATR)
LVE: 103091517(ATR)
OOR: 101282923(ATR)
ECB: 100062529(ATR)
EPZ: 103541038(ATR)
EAI: 106838125(ATR)
MYB: 102244634(ATR)
MYD: 102767838(ATR)
HAI: 109390465(ATR)
RSS: 109459252(ATR)
PALE: 102889339(ATR)
LAV: 100661281(ATR)
TMU: 101341680
MDO: 100019691(ATR)
SHR: 100934350(ATR)
OAA: 100073649(ATR)
GGA: 424777(ATR)
MGP: 100542484
CJO: 107318067(ATR)
APLA: 101799646(ATR)
ACYG: 106036175(ATR)
TGU: 100226379(ATR)
GFR: 102032229(ATR)
FAB: 101809341(ATR)
PHI: 102109906(ATR)
PMAJ: 107208960(ATR)
CCW: 104693498(ATR)
FPG: 101913264(ATR)
FCH: 102049948(ATR)
CLV: 102085982(ATR)
EGZ: 104127113(ATR)
AAM: 106485832(ATR)
ASN: 102377502(ATR)
AMJ: 102558385(ATR)
PSS: 102459396(ATR)
CMY: 102936864(ATR)
CPIC: 101945312(ATR)
ACS: 100561948(atr)
PBI: 103067932
GJA: 107112351(ATR)
XLA: 398197(atr.L)
XTR: 100495593(atr)
NPR: 108786355(ATR)
DRE: 567770(atr)
SRX: 107732932(atr)
SGH: 107553243(atr) 107576458
CCAR: 109054400
IPU: 108280302(atr)
AMEX: 103025436(atr)
TRU: 101071938(atr)
LCO: 104935263(atr) 109141019
MZE: 101475692(atr)
OLA: 101157099(atr)
XMA: 102225301(atr)
PRET: 103458428(atr)
NFU: 107392030(atr)
CSEM: 103379052(atr)
LCF: 108874985(atr)
HCQ: 109517427(atr)
BPEC: 110154962(atr)
SASA: 106574673 106591441(atr)
ELS: 105019805(atr)
SFM: 108935295(atr)
LCM: 102354343(ATR)
CMK: 103178297(atr)
CIN: 100177614
APLC: 110984731
SKO: 102803834
DME: Dmel_CG4252(mei-41)
DSI: Dsimw501_GD17284(Dsim_GD17284)
MDE: 101892149
AAG: 110680301
AME: 100576402
BIM: 100743410
BTER: 100646634
SOC: 105205280
AEC: 105152790
ACEP: 105623600
PBAR: 105429047
HST: 105185555
CFO: 105257424
LHU: 105676899
PGC: 109861539
NVI: 100117810
TCA: 655218(ATR)
DPA: 109537938
NVL: 108558133
BMOR: 101738504
PMAC: 106710139
PRAP: 110992194
API: 100164675
DNX: 107170732
ZNE: 110831919
FCD: 110853227
TUT: 107359078
BMY: Bm1_22870
TSP: Tsp_00544
OBI: 106868981
LAK: 106178691
EPA: 110234413
HMG: 100199469
AQU: 100639225
ATH: AT5G40820(ATR)
CRB: 17875125
BRP: 103864240
BOE: 106342817
THJ: 104824750
CPAP: 110819078
CIT: 102612093
TCC: 18607481
GRA: 105762955
DZI: 111298112
EGR: 104418985
GMX: 100804117
VRA: 106771906
VAR: 108325877
CCAJ: 109796133
CAM: 101507285
ADU: 107467309
AIP: 107618107
LJA: Lj5g3v2258320.1(Lj5g3v2258320.1)
LANG: 109346549
FVE: 101306989
PPER: 18767854
PMUM: 103334924
PAVI: 110753797
PXB: 103946588
ZJU: 107427404
CSV: 101212807
CMO: 103490258
MCHA: 111007695
CMAX: 111486403
CMOS: 111435314
CPEP: 111792389
RCU: 8272353
JCU: 105638496
HBR: 110653950
POP: 7470423
JRE: 109006624
VVI: 100245131
SLY: 101256634
SPEN: 107016704
SOT: 102598035
CANN: 107840599
NSY: 104248140
NTO: 104085701
INI: 109147567
SIND: 105169925
OEU: 111394196
HAN: 110940612
LSV: 111920839
DCR: 108226421
BVG: 104903878
SOE: 110789320
NNU: 104604322
OSA: 4342103
DOSA: Os06t0724700-01(Os06g0724700)
OBR: 102721939
BDI: 100846687
ATS: 109739817(LOC109739817)
SBI: 8065009
ZMA: 103626462
SITA: 101770836
PDA: 103722900
EGU: 105059675
MUS: 103998689
DCT: 110096219
AOF: 109844613
ATR: 18424206
PPP: 112283470
MNG: MNEG_7860
APRO: F751_3942
SLB: AWJ20_5275(MEC1)
NCR: NCU11188(mus-9)
NTE: NEUTE1DRAFT74353(NEUTE1DRAFT_74353)
MGR: MGG_02656
MAJ: MAA_11390
CMT: CCM_03432
MBE: MBM_07507
ANI: AN6975.2
ANG: ANI_1_4124(An14g00040)
ABE: ARB_06028
TVE: TRV_01175
PTE: PTT_05759
SPO: SPBC216.05(rad3)
CNE: CNE03070
CNB: CNBE3070
ABP: AGABI1DRAFT120011(AGABI1DRAFT_120011)
ABV: AGABI2DRAFT78376(AGABI2DRAFT_78376)
MGL: MGL_1121
DDI: DDB_G0291380(atr1)
DFA: DFA_05791(atr1)
EHI: EHI_197310(464.t00003)
BBO: BBOV_III011480(17.m07979)
CPV: cgd4_2670
SMIN: v1.2.040344.t1(symbB.v1.2.040344.t1) v1.2.040393.t1(symbB.v1.2.040393.t1)
FCY: FRACYDRAFT_188901(Rad3a)
SPAR: SPRG_05293
GTT: GUITHDRAFT_82439(ATR)
TCR: 511719.10
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Cimprich KA, Cortez D
  Title
ATR: an essential regulator of genome integrity.
  Journal
Nat Rev Mol Cell Biol 9:616-27 (2008)
DOI:10.1038/nrm2450
Reference
  Authors
Hall-Jackson CA, Cross DA, Morrice N, Smythe C
  Title
ATR is a caffeine-sensitive, DNA-activated protein kinase with a substrate specificity distinct from DNA-PK.
  Journal
Oncogene 18:6707-13 (1999)
DOI:10.1038/sj.onc.1203077
  Sequence
[hsa:545]

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