KEGG   ORTHOLOGY: K06643Help
Entry
K06643                      KO                                     

Name
MDM2
Definition
E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
Pathway
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04625  C-type lectin receptor signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05165  Human papillomavirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
Disease
H00025  Penile cancer
H00028  Choriocarcinoma
H00036  Osteosarcoma
H00037  Alveolar rhabdomyosarcoma
H00042  Glioma
H01513  Retinoblastoma
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04151 PI3K-Akt signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  Cell growth and death
   04110 Cell cycle
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04115 p53 signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04218 Cellular senescence
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Organismal Systems
  Immune system
   04625 C-type lectin receptor signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05202 Transcriptional misregulation in cancers
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05206 MicroRNAs in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05205 Proteoglycans in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05203 Viral carcinogenesis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05214 Glioma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05220 Chronic myeloid leukemia
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05218 Melanoma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05219 Bladder cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05215 Prostate cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  Infectious diseases
   05169 Epstein-Barr virus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05165 Human papillomavirus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  Drug resistance
   01524 Platinum drug resistance
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   01522 Endocrine resistance
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Membrane trafficking [BR:ko04131]
 Endocytosis
  Clathrin-mediated endocytosis
   Ubiquitin E3 ligases
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   MDM2/MDM4 proteins
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
BRITE hierarchy
Other DBs
GO: 0017163
Genes
HSA: 4193(MDM2)
PTR: 742141(MDM2)
PPS: 100968756(MDM2)
GGO: 101129964(MDM2)
PON: 100171532(MDM2)
NLE: 100601465(MDM2)
MCC: 718284(MDM2)
MCF: 102136323(MDM2)
CSAB: 103238687(MDM2)
RRO: 104658667(MDM2)
RBB: 108532254(MDM2) 108535938
CJC: 100415620(MDM2)
SBQ: 101036938(MDM2)
MMU: 17246(Mdm2)
RNO: 314856(Mdm2)
CGE: 100770120(Mdm2)
NGI: 103745079(Mdm2)
HGL: 101724821(Mdm2)
CCAN: 109693333(Mdm2)
OCU: 100340389(MDM2)
TUP: 102473924(MDM2)
CFA: 403693(MDM2)
AML: 100479481(MDM2)
UMR: 103656869(MDM2)
ORO: 101385402(MDM2)
FCA: 493939(MDM2)
PTG: 102965880(MDM2)
AJU: 106966348(MDM2)
BTA: 540378(MDM2)
BOM: 102287490(MDM2)
BIU: 109558399(MDM2) 109559244
PHD: 102322496 102339259(MDM2)
CHX: 102173163(MDM2)
OAS: 101103187 101104979(MDM2)
SSC: 100125959(MDM2)
CFR: 102522420(MDM2)
CDK: 105101086(MDM2)
BACU: 103017808(MDM2)
LVE: 103081431(MDM2)
OOR: 101286234(MDM2)
ECB: 100052084(MDM2)
EPZ: 103558340(MDM2)
EAI: 106843578(MDM2)
MYB: 102256024(MDM2)
MYD: 102759555 102771162(MDM2)
HAI: 109381699(MDM2)
RSS: 109456592(MDM2)
PALE: 102884281(MDM2)
LAV: 100669448(MDM2)
TMU: 101349408
MDO: 100021398(MDM2)
OAA: 100080712(MDM2)
GGA: 395609(MDM2)
MGP: 100546889(MDM2)
CJO: 107310502(MDM2)
APLA: 101805150(MDM2)
ACYG: 106046963(MDM2)
TGU: 100228592(MDM2)
GFR: 102041787(MDM2)
FAB: 101813089(MDM2)
PHI: 102099986(MDM2)
PMAJ: 107204718(MDM2)
CCW: 104698375(MDM2)
FPG: 101924125(MDM2)
FCH: 102048171(MDM2)
CLV: 102085264(MDM2)
EGZ: 104132910(MDM2)
AAM: 106488755(MDM2)
ASN: 102385768(MDM2)
AMJ: 102561091(MDM2)
PSS: 102447336(MDM2)
CMY: 102948375(MDM2)
CPIC: 101936483(MDM2)
ACS: 100556723(mdm2)
PVT: 110075109(MDM2)
PBI: 103063483(MDM2)
GJA: 107105724(MDM2)
XLA: 108711092(mdm2.L) 108713153
XTR: 394853(mdm2)
NPR: 108804551(MDM2)
DRE: 30637(mdm2)
IPU: 108279728(mdm2)
AMEX: 103039064(mdm2)
TRU: 101068181(mdm2)
LCO: 104927096(mdm2)
MZE: 101466094(mdm2)
OLA: 101174634(mdm2)
XMA: 102234130(mdm2)
PRET: 103459095(mdm2)
NFU: 107387038(mdm2)
CSEM: 103382446(mdm2)
LCF: 108880253 108895890(mdm2)
HCQ: 109532684(mdm2)
BPEC: 110161709(mdm2)
ELS: 105017801(mdm2)
SFM: 108936337(mdm2)
LCM: 102353921(MDM2)
CMK: 103185308(mdm2)
SPU: 100893740
TCA: 664204
NVL: 108569162
BMOR: 101745393
PMAC: 106714638
PXY: 105381544
ZNE: 110841453
CRG: 105324709
OBI: 106871879
EPA: 110244124
ADF: 107350549
HMG: 100205294
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tamborini E, Della Torre G, Lavarino C, Azzarelli A, Carpinelli P, Pierotti MA, Pilotti S
  Title
Analysis of the molecular species generated by MDM2 gene amplification in liposarcomas.
  Journal
Int J Cancer 92:790-6 (2001)
DOI:10.1002/ijc.1271
  Sequence
[hsa:4193]
Reference
  Authors
Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K
  Title
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
  Journal
J Biol Chem 285:4909-19 (2010)
DOI:10.1074/jbc.M109.042341
Reference
PMID:1614537
  Authors
Oliner JD, Kinzler KW, Meltzer PS, George DL, Vogelstein B
  Title
Amplification of a gene encoding a p53-associated protein in human sarcomas.
  Journal
Nature 358:80-3 (1992)
DOI:10.1038/358080a0
  Sequence
[hsa:4193]

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