KEGG   ORTHOLOGY: K06643Help
Entry
K06643                      KO                                     

Name
MDM2
Definition
E3 ubiquitin-protein ligase Mdm2 [EC:6.3.2.19]
Pathway
FoxO signaling pathway
Cell cycle
p53 signaling pathway
Ubiquitin mediated proteolysis
Endocytosis
PI3K-Akt signaling pathway
Thyroid hormone signaling pathway
Epstein-Barr virus infection
Pathways in cancer
Transcriptional misregulation in cancer
Viral carcinogenesis
Proteoglycans in cancer
MicroRNAs in cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Disease
H00025  
Penile cancer
H00028  
Choriocarcinoma
H00036  
Osteosarcoma
H00037  
Alveolar rhabdomyosarcoma
H00042  
Glioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04151 PI3K-Akt signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  Cell growth and death
   04110 Cell cycle
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   04115 p53 signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Organismal Systems
  Endocrine system
   04919 Thyroid hormone signaling pathway
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05202 Transcriptional misregulation in cancers
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05206 MicroRNAs in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05205 Proteoglycans in cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05203 Viral carcinogenesis
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05214 Glioma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05220 Chronic myeloid leukemia
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05218 Melanoma
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05219 Bladder cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
   05215 Prostate cancer
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
  Infectious diseases
   05169 Epstein-Barr virus infection
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.19  ubiquitin---protein ligase
     K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  single Ring-finger type E3
   MDM2/MDM4 proteins
    K06643  MDM2; E3 ubiquitin-protein ligase Mdm2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
4193(MDM2)
PTR: 
742141(MDM2)
PPS: 
100968756(MDM2)
GGO: 
101129964(MDM2)
PON: 
100171532(MDM2)
MCC: 
718284(MDM2)
MCF: 
102136323(MDM2)
MMU: 
17246(Mdm2)
RNO: 
314856(Mdm2)
CGE: 
100770120(Mdm2)
HGL: 
101724821(Mdm2)
TUP: 
102473924(MDM2)
CFA: 
403693(MDM2)
AML: 
FCA: 
493939(MDM2)
PTG: 
102965880(MDM2)
BTA: 
540378(MDM2)
BOM: 
102287490(MDM2)
PHD: 
CHX: 
102173163(MDM2)
SSC: 
100125959(MDM2)
CFR: 
102522420(MDM2)
BACU: 
103017808(MDM2)
LVE: 
103081431(MDM2)
ECB: 
100052084(MDM2)
MYB: 
102256024(MDM2)
MYD: 
PALE: 
102884281(MDM2)
MDO: 
100021398(MDM2)
SHR: 
OAA: 
100080712(MDM2)
GGA: 
395609(MDM2)
MGP: 
TGU: 
100228592(MDM2)
FAB: 
101813089(MDM2)
PHI: 
102099986(MDM2)
APLA: 
101805150(MDM2)
FPG: 
101924125(MDM2)
FCH: 
102048171(MDM2)
CLV: 
102085264(MDM2)
ASN: 
102385768(MDM2)
AMJ: 
102561091(MDM2)
PSS: 
102447336(MDM2)
CMY: 
102948375(MDM2)
ACS: 
PBI: 
103063483(MDM2)
XLA: 
444499(mdm2)
XTR: 
394853(mdm2)
DRE: 
30637(mdm2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353921(MDM2)
CMK: 
103185308(mdm2)
BFO: 
SPU: 
TCA: 
BMOR: 
PHU: 
ISC: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Marine JC, Lozano G
  Title
Mdm2-mediated ubiquitylation: p53 and beyond.
  Journal
Cell Death Differ 17:93-102 (2010)
Reference
  Authors
Taira N, Yamamoto H, Yamaguchi T, Miki Y, Yoshida K
  Title
ATM augments nuclear stabilization of DYRK2 by inhibiting MDM2 in the apoptotic response to DNA damage.
  Journal
J Biol Chem 285:4909-19 (2010)

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