KEGG   ORTHOLOGY: K06645Help
Entry
K06645                      KO                                     

Name
CDC25A
Definition
M-phase inducer phosphatase 1 [EC:3.1.3.48]
Pathway
ko04110  Cell cycle
ko04218  Cellular senescence
ko04914  Progesterone-mediated oocyte maturation
ko05206  MicroRNAs in cancer
Module
M00691  DNA damage-induced cell cycle checkpoints
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K06645  CDC25A; M-phase inducer phosphatase 1
   04218 Cellular senescence
    K06645  CDC25A; M-phase inducer phosphatase 1
 Organismal Systems
  Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K06645  CDC25A; M-phase inducer phosphatase 1
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K06645  CDC25A; M-phase inducer phosphatase 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00691  DNA damage-induced cell cycle checkpoints
     K06645  CDC25A; M-phase inducer phosphatase 1
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.3  Phosphoric-monoester hydrolases
    3.1.3.48  protein-tyrosine-phosphatase
     K06645  CDC25A; M-phase inducer phosphatase 1
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Tyrosine phosphatases (PTPs)
  Class III PTPs
   CDC25s
    K06645  CDC25A; M-phase inducer phosphatase 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K06645  CDC25A; M-phase inducer phosphatase 1
BRITE hierarchy
Other DBs
GO: 0004725
Genes
HSA: 993(CDC25A)
PTR: 460341(CDC25A)
PPS: 100985899(CDC25A)
GGO: 101142222(CDC25A)
PON: 100460228(CDC25A)
NLE: 100588003(CDC25A)
MCC: 710858(CDC25A)
MCF: 102137696(CDC25A)
CSAB: 103228635(CDC25A)
RRO: 104671299(CDC25A)
RBB: 108517663(CDC25A)
CJC: 100408832(CDC25A)
SBQ: 101041208(CDC25A)
MMU: 12530(Cdc25a)
RNO: 171102(Cdc25a)
CGE: 100767961(Cdc25a)
NGI: 103750230(Cdc25a)
HGL: 101699133(Cdc25a)
CCAN: 109699005(Cdc25a)
OCU: 100354280(CDC25A)
TUP: 102482369(CDC25A)
CFA: 484780(CDC25A)
AML: 100477247(CDC25A)
UMR: 103675112(CDC25A)
ORO: 101369809(CDC25A)
FCA: 101098445(CDC25A)
PTG: 102957057(CDC25A)
AJU: 106979176(CDC25A)
BTA: 520188(CDC25A)
BOM: 102285046(CDC25A)
BIU: 109576463(CDC25A)
PHD: 102326574(CDC25A)
CHX: 102181731(CDC25A)
OAS: 101113178(CDC25A)
SSC: 100737380(CDC25A)
CFR: 102509600(CDC25A)
CDK: 105103857(CDC25A)
BACU: 103016547(CDC25A)
LVE: 103085456(CDC25A)
OOR: 101282274(CDC25A)
ECB: 100064223(CDC25A)
EPZ: 103567910(CDC25A)
EAI: 106821782(CDC25A)
MYD: 102760761(CDC25A)
HAI: 109375294(CDC25A)
RSS: 109443501(CDC25A)
PALE: 102897196(CDC25A)
LAV: 100659991(CDC25A)
TMU: 101346532
MDO: 100018150(CDC25A)
SHR: 100924467(CDC25A)
OAA: 100085311(CDC25A)
GGA: 420375(CDC25A)
MGP: 100546502(CDC25A)
CJO: 107308656(CDC25A)
APLA: 101800901(CDC25A)
ACYG: 106046801(CDC25A)
TGU: 100231363(CDC25A)
GFR: 102040683(CDC25A)
FAB: 101816817(CDC25A)
PHI: 102104005(CDC25A)
PMAJ: 107201060(CDC25A)
CCW: 104686374(CDC25A)
FPG: 101911899(CDC25A)
FCH: 102054923(CDC25A)
CLV: 102084553(CDC25A)
EGZ: 104121808(CDC25A)
AAM: 106499367
ASN: 102384816(CDC25A)
AMJ: 102569214(CDC25A)
PSS: 102458852(CDC25A)
CMY: 102931776(CDC25A)
CPIC: 101944298(CDC25A)
ACS: 100558641(cdc25a) 103280245
PVT: 110082540(CDC25A)
PBI: 103059140(CDC25A)
GJA: 107124887(CDC25A)
XLA: 398141 734734(cdc25a.S)
XTR: 733851(cdc25a)
SGH: 107594325
CCAR: 109057633
SFM: 108933541
CIN: 100177918
OBI: 106880873
HMG: 100214595
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Karlsson-Rosenthal C, Millar JB
  Title
Cdc25: mechanisms of checkpoint inhibition and recovery.
  Journal
Trends Cell Biol 16:285-92 (2006)
DOI:10.1016/j.tcb.2006.04.002
Reference
  Authors
Hong HY, Choi J, Cho YW, Kim BC
  Title
Cdc25A promotes cell survival by stimulating NF-kappaB activity through IkappaB-alpha phosphorylation and destabilization.
  Journal
Biochem Biophys Res Commun 420:293-6 (2012)
DOI:10.1016/j.bbrc.2012.02.152
  Sequence
[hsa:993]

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