KEGG   ORTHOLOGY: K06751Help
Entry
K06751                      KO                                     

Name
MHC1
Definition
major histocompatibility complex, class I
Pathway
ko04144  Endocytosis
ko04145  Phagosome
ko04218  Cellular senescence
ko04514  Cell adhesion molecules (CAMs)
ko04612  Antigen processing and presentation
ko04940  Type I diabetes mellitus
ko05165  Human papillomavirus infection
ko05166  HTLV-I infection
ko05167  Kaposi's sarcoma-associated herpesvirus infection
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
ko05203  Viral carcinogenesis
ko05320  Autoimmune thyroid disease
ko05330  Allograft rejection
ko05332  Graft-versus-host disease
ko05416  Viral myocarditis
Disease
H00344  Leprosy
H01476  Behcet disease
H01507  Seronegative arthritis (SpA)
H01674  Ankylosing spondylitis
H01694  Stevens-Johnson syndrome and toxic epidermal necrolysis
H01713  Diffuse panbronchiolitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signaling molecules and interaction
   04514 Cell adhesion molecules (CAMs)
    K06751  MHC1; major histocompatibility complex, class I
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K06751  MHC1; major histocompatibility complex, class I
   04145 Phagosome
    K06751  MHC1; major histocompatibility complex, class I
  Cell growth and death
   04218 Cellular senescence
    K06751  MHC1; major histocompatibility complex, class I
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06751  MHC1; major histocompatibility complex, class I
   04612 Antigen processing and presentation
    K06751  MHC1; major histocompatibility complex, class I
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K06751  MHC1; major histocompatibility complex, class I
  Immune diseases
   05320 Autoimmune thyroid disease
    K06751  MHC1; major histocompatibility complex, class I
   05330 Allograft rejection
    K06751  MHC1; major histocompatibility complex, class I
   05332 Graft-versus-host disease
    K06751  MHC1; major histocompatibility complex, class I
  Cardiovascular diseases
   05416 Viral myocarditis
    K06751  MHC1; major histocompatibility complex, class I
  Endocrine and metabolic diseases
   04940 Type I diabetes mellitus
    K06751  MHC1; major histocompatibility complex, class I
  Infectious diseases
   05166 HTLV-I infection
    K06751  MHC1; major histocompatibility complex, class I
   05168 Herpes simplex infection
    K06751  MHC1; major histocompatibility complex, class I
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K06751  MHC1; major histocompatibility complex, class I
   05169 Epstein-Barr virus infection
    K06751  MHC1; major histocompatibility complex, class I
   05165 Human papillomavirus infection
    K06751  MHC1; major histocompatibility complex, class I
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K06751  MHC1; major histocompatibility complex, class I
Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:ko00537]
 Antigens
  K06751  MHC1; major histocompatibility complex, class I
BRITE hierarchy
Other DBs
GO: 0030106
Genes
HSA: 3105(HLA-A) 3106(HLA-B) 3107(HLA-C) 3133(HLA-E) 3134(HLA-F) 3135(HLA-G)
PTR: 100169977(PATR-F) 450202(PATR-B) 462540(PATR-E) 463178(PATR-AL) 471962(PATR-C) 494187(PATR-G) 750725(PATR-A)
PPS: 100977055 100978112(Papa-A) 100978457(MHC-F) 100978774(MHC-G) 100979338(HLA-H) 100982294(Papa-C) 100982859(PAPA-B) 100993452
GGO: 101141279 101142134 101142998 101143843(MHC-G) 101144465 101150824 101153360(MHC-E) 109027164
PON: 100173719(DKFZP469M1914) 100189734 100432875 100435866 100438533 100440558 100450716 100452132 100456603
NLE: 100579523 100587765 100588639 100592911 100604779 105739027
MCC: 100141394(MAMU-B18) 106996081(Mamu-B) 694372 699243(MAMU-A3) 700391(MAMU-B) 709076(MAMU-F) 711532(MAMU-E) 711832(MAMU-A) 714964(Mamu-B) 715737(Mamu-A) 720372(MAMU-I) 722711(MHC-E) 723473(Mamu-B) 723514(Mamu-A)
MCF: 102114865(Mafa-A) 102116897(Mafa) 102117143(Mafa-A) 102120132(Mafa) 102121775(Mafa) 102122138(MAFA-F) 102123548(Mafa-B) 102125623(Mafa) 102132408(Mafa) 102132794(Mafa-A) 102138874(MHC-E) 102138883(Mafa-B) 102138996(Mafa-B) 102140389(Mafa-B) 102141835(Mafa-B) 102142617(Mafa-B) 102143405(Mafa-B) 102145054 102145933(Mafa-I)
CSAB: 103221775(Chsa-B) 103221786(Chsa-B) 103221837(Chsa-A) 103221863 103222361 103222362 103247140(Chsa-A) 103247147
RRO: 104658140 104659359 104666183 104668193 104668434 104669987 104670209 104672273 104672319 104673193 104674706 104676771 104678248 104678463
MMU: 100529082(Gm11127) 110557(H2-Q6) 110558(H2-Q9) 110696(H2-M10.3) 14963(H2-Bl) 14964(H2-D1) 14972(H2-K1) 14980(H2-L) 14985(H2-M10.1) 14990(H2-M2) 14991(H2-M3) 14997(H2-M9) 15006(H2-Q1) 15007(H2-Q10) 15013(H2-Q2) 15015(H2-Q4) 15018(H2-Q7) 15019(H2-Q8) 15024(H2-T10) 15033(H2-T18) 15039(H2-T22) 15040(H2-T23) 15042(H2-T24) 15043(H2-T3) 15051(H2-T9) 224753(H2-M10.4) 224754(H2-M11) 224756(H2-M1) 224761(H2-M10.5) 240095(H2-M5) 333715(H2-M10.2) 399549(H2-M10.6) 547349 630294(Gm7030) 667803(H2-T-ps) 667977(Gm8909) 69717(Gm10499)
RNO: 100188935(RT1-A) 102546590 24737(RT1-EC2) 24747(RT1-M3-1) 24748(RT1-N1) 24750(RT1-N3) 24751(RT1-O1) 24973(RT1-A1) 24974(RT1-A2) 24977(RT1-Cl) 24988(RT1-M2) 294213(RT1-M1-4) 294228(RT1-S3) 309584(RT1-M4) 309600(RT1-CE12) 309603(RT1-CE1) 309607(RT1-CE5) 309627(RT1-A3) 360323(RT1-N2) 361787(RT1-T24-1) 365527(RT1-M6-2) 368153(RT1-CE7) 406194(RT1-T18) 414270(RT1-CE14) 414779(RT1-CE2) 414783(RT1-CE4) 414784(RT1-T24-4) 414785(RT1-M6-1) 414786(RT1-M1-2) 414787(RT1-M10-1) 414788(RT1-T24-3) 414789(RT1-CE15) 414790(RT1-CE13) 414791(RT1-CE11) 414792(RT1-CE10) 414793(RT1-CE3) 414819(RT1-CE16) 499400(RT1-M5) 680842(RT1-M1-5)
CFA: 474836(DLA88) 474838(DLA-64) 483594(DLA-79)
AML: 100466374 100476691(AIME-152) 100483904
BTA: 100125916 100126048(BOLA-N) 407173(JSP.1) 505676(BOLA) 507917(BOLA) 509006 510417(BOLA-NC1) 512672 515712(BOLA) 533049(BOLA) 533050(BoLA) 616942 751813(BOLA) 767904 782684(BOLA-A) 788634 790811(BOLA)
SSC: 100037288(SLA-3) 100037293(SLA-1) 100135029(SLA-5) 100135031(SLA-2) 100135036(SLA-8) 100135037(SLA-6) 100626428(TRIM52) 396650(SLA-7)
MDO: 100024719(Mhc-1) 100026156(MODO-UM) 100026178(MODO-UE) 100026665(MODO-UJ) 100026781(MODO-UI) 100026802(Modo-UA) 100026822(MODO-UK) 751097(MHC-1) 790902(MODO-UB) 790903(MODO-UC)
SHR: 100913535(SAHAI-01) 100919863(SAHAI-12) 100926320 100927947 100928906
GGA: 100857553 417057 425389(BF2) 427746(YF5) 693260(BF1)
APLA: 101790497(Anpl-U) 101797502
TGU: 100231469
GFR: 102034923(FCGRT) 102039800
FPG: 101924893
FCH: 102052467
XLA: 100036891 100126623 108698552(Xela-UAA) 108705614(Xela-UAA) 373808(mhc1a.L) 379561(hla-a.L) 398628 779227(mr1.L)
DRE: 393557(mhc1uxa2) 64885(mhc1uea)
NCC: 104968013
SASA: 106569843 106569935 106569936(Sasa-ZCA) 106569938(Sasa-ZBA) 106569947(Sasa-UGA) 106581890 106582436(Sasa-UHA) 106588377(HA1L) 106588378 106588380(Sasa-ZE) 106588381(Sasa-ZAA) 106588401(Sasa-UBA) 106588402(Sasa-UBA) 106592784 106597015 106597513 106599071
LCM: 102345098(Lach-UX-02) 102345632(Lach-UB-03) 102345904(Lach-UB-05) 102348044 102348567(Lach-UC-01) 102351815(Lach-UB-02) 102356466 102358245(Lach-UA-01) 102360671(Lach-UA-02) 102360930 102365553(Lach-UD-01) 102365812 102365873 106706643(Lach-UB-05)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Belicha-Villanueva A, Blickwedehl J, McEvoy S, Golding M, Gollnick SO, Bangia N
  Title
What is the role of alternate splicing in antigen presentation by major histocompatibility complex class I molecules?
  Journal
Immunol Res 46:32-44 (2010)
DOI:10.1007/s12026-009-8123-8
Reference
  Authors
Sleiman M, Brons NH, Kaoma T, Dogu F, Villa-Forte A, Lenoble P, Hentges F, Kotsch K, Gadola SD, Vilches C, Zimmer J
  Title
NK cell killer Ig-like receptor repertoire acquisition and maturation are strongly modulated by HLA class I molecules.
  Journal
J Immunol 192:2602-10 (2014)
DOI:10.4049/jimmunol.1302843
  Sequence
[hsa:3105 3106 3107]

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