KEGG   ORTHOLOGY: K06856Help
Entry
K06856                      KO                                     
Name
IGH
Definition
immunoglobulin heavy chain
Pathway
Calcium signaling pathway
NF-kappa B signaling pathway
Phagosome
PI3K-Akt signaling pathway
Hematopoietic cell lineage
Natural killer cell mediated cytotoxicity
B cell receptor signaling pathway
Fc epsilon RI signaling pathway
Fc gamma R-mediated phagocytosis
Intestinal immune network for IgA production
Leishmaniasis
African trypanosomiasis
Amoebiasis
Staphylococcus aureus infection
Tuberculosis
Measles
Epstein-Barr virus infection
Transcriptional misregulation in cancer
Asthma
Autoimmune thyroid disease
Systemic lupus erythematosus
Rheumatoid arthritis
Allograft rejection
Primary immunodeficiency
Dilated cardiomyopathy
Viral myocarditis
Disease
H00010  
Multiple myeloma
H00011  
Lymphoplasmacytic lymphoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04020 Calcium signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04151 PI3K-Akt signaling pathway
    K06856  IGH; immunoglobulin heavy chain
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K06856  IGH; immunoglobulin heavy chain
 Organismal Systems
  Immune system
   04640 Hematopoietic cell lineage
    K06856  IGH; immunoglobulin heavy chain
   04650 Natural killer cell mediated cytotoxicity
    K06856  IGH; immunoglobulin heavy chain
   04662 B cell receptor signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04664 Fc epsilon RI signaling pathway
    K06856  IGH; immunoglobulin heavy chain
   04666 Fc gamma R-mediated phagocytosis
    K06856  IGH; immunoglobulin heavy chain
   04672 Intestinal immune network for IgA production
    K06856  IGH; immunoglobulin heavy chain
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K06856  IGH; immunoglobulin heavy chain
  Immune diseases
   05310 Asthma
    K06856  IGH; immunoglobulin heavy chain
   05322 Systemic lupus erythematosus
    K06856  IGH; immunoglobulin heavy chain
   05323 Rheumatoid arthritis
    K06856  IGH; immunoglobulin heavy chain
   05320 Autoimmune thyroid disease
    K06856  IGH; immunoglobulin heavy chain
   05330 Allograft rejection
    K06856  IGH; immunoglobulin heavy chain
   05340 Primary immunodeficiency
    K06856  IGH; immunoglobulin heavy chain
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K06856  IGH; immunoglobulin heavy chain
   05416 Viral myocarditis
    K06856  IGH; immunoglobulin heavy chain
  Infectious diseases
   05150 Staphylococcus aureus infection
    K06856  IGH; immunoglobulin heavy chain
   05152 Tuberculosis
    K06856  IGH; immunoglobulin heavy chain
   05162 Measles
    K06856  IGH; immunoglobulin heavy chain
   05169 Epstein-Barr virus infection
    K06856  IGH; immunoglobulin heavy chain
   05146 Amoebiasis
    K06856  IGH; immunoglobulin heavy chain
   05140 Leishmaniasis
    K06856  IGH; immunoglobulin heavy chain
   05143 African trypanosomiasis
    K06856  IGH; immunoglobulin heavy chain
BRITE hierarchy
Genes
PTR: 
PON: 
MCC: 
MMU: 
16061(Igh-VJ558)
RNO: 
CFA: 
BTA: 
SSC: 
ECB: 
MDO: 
OAA: 
100078549 100091720
MGP: 
100539074 100540310
ACS: 
100553338 100554006 100554394
XTR: 
100485957 548369
DRE: 
100535789(ighv6-2) 100535916(ighv4-7)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Chaudhuri J, Basu U, Zarrin A, Yan C, Franco S, Perlot T, Vuong B, Wang J, Phan RT, Datta A, Manis J, Alt FW
  Title
Evolution of the immunoglobulin heavy chain class switch recombination mechanism.
  Journal
Adv Immunol 94:157-214 (2007)
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