KEGG   ORTHOLOGY: K07187Help
Entry
K07187                      KO                                     

Name
IRS2
Definition
insulin receptor substrate 2
Pathway
cGMP-PKG signaling pathway
FoxO signaling pathway
AMPK signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04022 cGMP - PKG signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04152 AMPK signaling pathway
    K07187  IRS2; insulin receptor substrate 2
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07187  IRS2; insulin receptor substrate 2
   04920 Adipocytokine signaling pathway
    K07187  IRS2; insulin receptor substrate 2
 Human Diseases
  Cancers
   05206 MicroRNAs in cancer
    K07187  IRS2; insulin receptor substrate 2
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K07187  IRS2; insulin receptor substrate 2
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07187  IRS2; insulin receptor substrate 2
BRITE hierarchy
Genes
HSA: 
8660(IRS2)
PTR: 
452657(IRS2)
PPS: 
100982406(IRS2)
GGO: 
101127585(IRS2)
NLE: 
100583956(IRS2)
MCC: 
698536(IRS2)
MCF: 
102122241(IRS2)
CJC: 
100404822(IRS2)
MMU: 
384783(Irs2)
RNO: 
29376(Irs2)
CGE: 
100771848(Irs2)
HGL: 
101719081(Irs2)
TUP: 
102497747(IRS2)
CFA: 
485548(IRS2)
AML: 
100477685(IRS2)
UMR: 
103657626(IRS2)
FCA: 
101095791(IRS2)
BTA: 
100300012(IRS2)
BACU: 
103005810(IRS2)
LVE: 
103088704(IRS2)
ECB: 
100146249(IRS2)
MYB: 
102249810(IRS2)
MYD: 
102753060(IRS2)
PALE: 
102898575(IRS2)
MDO: 
SHR: 
GGA: 
MGP: 
APLA: 
TGU: 
FAB: 
PHI: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
102934421(IRS2)
ACS: 
PBI: 
XLA: 
399388(irs4) 495836(irs2)
XTR: 
DRE: 
100329897(irs4a) 393285 572001(irs2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
CQU: 
ISC: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Giovannone B, Scaldaferri ML, Federici M, Porzio O, Lauro D, Fusco A, Sbraccia P, Borboni P, Lauro R, Sesti G
  Title
Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.
  Journal
Diabetes Metab Res Rev 16:434-41 (2000)

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