KEGG   ORTHOLOGY: K07206Help
Entry
K07206                      KO                                     

Name
TSC1
Definition
tuberous sclerosis 1
Pathway
Phospholipase D signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Insulin signaling pathway
Choline metabolism in cancer
Disease
H00896  
Lymphangioleiomyomatosis (LAM)
H00915  
Tuberous sclerosis complex (TSC)
H01251  
Focal cortical dysplasia of Taylor
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04151 PI3K-Akt signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04152 AMPK signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04150 mTOR signaling pathway
    K07206  TSC1; tuberous sclerosis 1
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07206  TSC1; tuberous sclerosis 1
  Aging
   04211 Longevity regulating pathway - mammal
    K07206  TSC1; tuberous sclerosis 1
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K07206  TSC1; tuberous sclerosis 1
BRITE hierarchy
Genes
HSA: 
7248(TSC1)
PTR: 
464818(TSC1)
PPS: 
100975575(TSC1)
GGO: 
101137273(TSC1)
PON: 
100147742(TSC1)
NLE: 
100587112(TSC1)
MCC: 
714645(TSC1)
MCF: 
102124229(TSC1)
CSAB: 
103239711(TSC1)
RRO: 
104669743(TSC1)
CJC: 
100407741(TSC1)
SBQ: 
101028002(TSC1)
MMU: 
64930(Tsc1)
RNO: 
60445(Tsc1)
CGE: 
100767621(Tsc1)
NGI: 
103742835(Tsc1)
HGL: 
101708424(Tsc1)
OCU: 
100338695(TSC1)
TUP: 
102483474(TSC1)
CFA: 
480688(TSC1)
AML: 
100471530(TSC1)
UMR: 
103670250(TSC1)
FCA: 
101101514(TSC1)
PTG: 
102953770(TSC1)
BTA: 
533440(TSC1)
BOM: 
102280709(TSC1)
PHD: 
102315907(TSC1)
CHX: 
102178739(TSC1)
OAS: 
101119127(TSC1)
SSC: 
100154726(TSC1)
CFR: 
102504505(TSC1)
BACU: 
103010162(TSC1)
LVE: 
103088278(TSC1)
ECB: 
100066615(TSC1)
MYB: 
102245381(TSC1)
MYD: 
102752713(TSC1)
PALE: 
102878835(TSC1)
LAV: 
100667008(TSC1)
MDO: 
100017591(TSC1)
SHR: 
100918165(TSC1)
OAA: 
100080641(TSC1)
GGA: 
417166(TSC1)
MGP: 
100539473(TSC1)
CJO: 
107321823(TSC1)
APLA: 
101798545(TSC1)
TGU: 
100228268(TSC1)
GFR: 
102040493(TSC1)
FAB: 
101806512(TSC1)
PHI: 
102103020(TSC1)
CCW: 
104688322(TSC1)
FPG: 
101921096(TSC1)
FCH: 
102050812(TSC1)
CLV: 
102094746(TSC1)
AAM: 
106483762(TSC1)
ASN: 
102383470(TSC1)
AMJ: 
102560300(TSC1)
PSS: 
102453047(TSC1)
CMY: 
102939516(TSC1)
ACS: 
100560493(tsc1)
PBI: 
103052506(TSC1)
GJA: 
107112796(TSC1)
XTR: 
100380126(tsc1)
DRE: 
100330617(tsc1b) 337167(tsc1a)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
102358393(TSC1)
CMK: 
103184683(tsc1)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD21066(Dsim_GD21066)
DWI: 
DYA: 
Dyak_GE23448(dyak_GLEANR_7234)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
724223(Tsc1)
BIM: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
API: 
PHU: 
DPX: 
ISC: 
BMY: 
LOA: 
TSP: 
LGI: 
CRG: 
105327465(Hamartin)
OBI: 
ADF: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9242607
  Authors
van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP, Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ
  Title
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.
  Journal
Science 277:805-8 (1997)
  Sequence
[hsa:7248]
Reference
  Authors
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J
  Title
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
  Journal
Proc Natl Acad Sci U S A 99:13571-6 (2002)
  Sequence
[hsa:7248]

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