KEGG   ORTHOLOGY: K07207Help
Entry
K07207                      KO                                     

Name
TSC2
Definition
tuberous sclerosis 2
Pathway
Phospholipase D signaling pathway
p53 signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Insulin signaling pathway
Thyroid hormone signaling pathway
Choline metabolism in cancer
Disease
H00896  
Lymphangioleiomyomatosis (LAM)
H00915  
Tuberous sclerosis complex (TSC)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04072 Phospholipase D signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04151 PI3K-Akt signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04152 AMPK signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04150 mTOR signaling pathway
    K07207  TSC2; tuberous sclerosis 2
 Cellular Processes
  Cell growth and death
   04115 p53 signaling pathway
    K07207  TSC2; tuberous sclerosis 2
 Organismal Systems
  Endocrine system
   04910 Insulin signaling pathway
    K07207  TSC2; tuberous sclerosis 2
   04919 Thyroid hormone signaling pathway
    K07207  TSC2; tuberous sclerosis 2
  Aging
   04211 Longevity regulating pathway - mammal
    K07207  TSC2; tuberous sclerosis 2
 Human Diseases
  Cancers
   05231 Choline metabolism in cancer
    K07207  TSC2; tuberous sclerosis 2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K07207  TSC2; tuberous sclerosis 2
BRITE hierarchy
Genes
HSA: 
7249(TSC2)
PTR: 
468086(TSC2)
PPS: 
100971050(TSC2)
GGO: 
101137934(TSC2)
PON: 
100441126(TSC2)
NLE: 
100604902(TSC2)
MCC: 
694965(TSC2)
MCF: 
102140628(TSC2)
RRO: 
104681538(TSC2)
CJC: 
100390664(TSC2)
MMU: 
22084(Tsc2)
RNO: 
24855(Tsc2)
CGE: 
100755849(Tsc2)
NGI: 
103752451(Tsc2)
HGL: 
101713968(Tsc2)
OCU: 
100351640(TSC2)
TUP: 
102484276(TSC2)
CFA: 
479883(TSC2)
AML: 
100465690(TSC2)
UMR: 
103668779(TSC2)
FCA: 
101082969(TSC2)
PTG: 
102956176(TSC2)
BTA: 
504985(TSC2)
BOM: 
102267343(TSC2)
PHD: 
102335737(TSC2)
CHX: 
100860943(TSC2)
OAS: 
101115088(TSC2)
SSC: 
100505408(TSC2)
CFR: 
102523349(TSC2)
BACU: 
103008177(TSC2)
LVE: 
103075350(TSC2)
ECB: 
100065679(TSC2)
MYB: 
102253389(TSC2)
MYD: 
102770093(TSC2)
PALE: 
102898762(TSC2)
MDO: 
100011431(TSC2)
SHR: 
100918445(TSC2)
OAA: 
100086661(TSC2)
GGA: 
416552(TSC2)
MGP: 
100542960(TSC2)
APLA: 
101804966(TSC2)
TGU: 
100222231(TSC2)
GFR: 
102039715(TSC2)
FAB: 
101818727(TSC2)
PHI: 
102110699(TSC2)
CCW: 
104684745(TSC2)
FPG: 
101919684(TSC2)
FCH: 
102055452(TSC2)
CLV: 
102098310(TSC2)
ASN: 
102387523(TSC2)
AMJ: 
102558178(TSC2)
PSS: 
102448020(TSC2)
CMY: 
102946461(TSC2)
ACS: 
PBI: 
XTR: 
100170546(tsc2)
DRE: 
TRU: 
101078033(tsc2)
MZE: 
101468908(tsc2)
OLA: 
101168435(tsc2)
XMA: 
102219500(tsc2)
LCM: 
102365821(TSC2)
CMK: 
103189890(tsc2)
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
Dyak_GE19646(dyak_GLEANR_3507) Dyak_GE22755(dyak_GLEANR_6501) Dyak_GE22756(dyak_GLEANR_6502)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
412278(gig)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
660002(TSC2)
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
LGI: 
CRG: 
105344173(Tuberin)
OBI: 
NVE: 
HMG: 
TAD: 
AQU: 
MBR: 
DDI: 
DPP: 
DFA: 
ACAN: 
PIF: 
PSOJ: 
SPAR: 
GTT: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Orlova KA, Crino PB
  Title
The tuberous sclerosis complex.
  Journal
Ann N Y Acad Sci 1184:87-105 (2010)
Reference
  Authors
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J
  Title
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
  Journal
Proc Natl Acad Sci U S A 99:13571-6 (2002)
  Sequence
[hsa:7249]

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