KEGG   ORTHOLOGY: K07209Help
Entry
K07209                      KO                                     

Name
IKBKB, IKKB
Definition
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Pathway
MAPK signaling pathway
Ras signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Hepatitis C
Hepatitis B
Influenza A
HTLV-I infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Module
M00686  
Toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04010 MAPK signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04064 NF-kappa B signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04668 TNF signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04068 FoxO signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04151 PI3K-Akt signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04150 mTOR signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04621 NOD-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04622 RIG-I-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04623 Cytosolic DNA-sensing pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04660 T cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04662 B cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04062 Chemokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Endocrine system
   04910 Insulin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04920 Adipocytokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Nervous system
   04722 Neurotrophin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Development
   04380 Osteoclast differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05206 MicroRNAs in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05212 Pancreatic cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05221 Acute myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05220 Chronic myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05215 Prostate cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05222 Small cell lung cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05131 Shigellosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05166 HTLV-I infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05164 Influenza A
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05161 Hepatitis B
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05160 Hepatitis C
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05168 Herpes simplex infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05169 Epstein-Barr virus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05145 Toxoplasmosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05142 Chagas disease (American trypanosomiasis)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Other group
  IKK family [OT]
   K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3551(IKBKB)
PTR: 
472749(IKBKB)
PPS: 
100989390(IKBKB)
GGO: 
101141659(IKBKB)
PON: 
100440586(IKBKB)
NLE: 
100588081(IKBKB)
MCC: 
704683(IKBKB)
MCF: 
102146604(IKBKB)
CJC: 
100393096(IKBKB)
MMU: 
16150(Ikbkb)
RNO: 
84351(Ikbkb)
CGE: 
100750488(Ikbkb)
NGI: 
103726621(Ikbkb)
HGL: 
101711077(Ikbkb)
OCU: 
100356401(IKBKB)
TUP: 
102467954(IKBKB)
CFA: 
482839(IKBKB)
AML: 
100471679(IKBKB)
UMR: 
103677059(IKBKB)
FCA: 
100142682(IKBKB)
PTG: 
102963734(IKBKB)
BTA: 
281854(IKBKB)
BOM: 
102281443(IKBKB)
PHD: 
102337166(IKBKB)
CHX: 
102177406(IKBKB)
OAS: 
780484(IKKBETA)
SSC: 
100101471(IKBKB)
CFR: 
102508142(IKBKB)
BACU: 
103015119(IKBKB)
LVE: 
103088633(IKBKB)
ECB: 
100050167(IKBKB)
MYB: 
102261405(IKBKB)
MYD: 
102773824(IKBKB)
PALE: 
102893261(IKBKB)
MDO: 
100033031(IKBKB)
SHR: 
100928932(IKBKB)
OAA: 
100078925(IKBKB)
GGA: 
426792(IKBKB)
MGP: 
APLA: 
101790255(IKBKB)
TGU: 
100225072(IKBKB)
FAB: 
101809821(IKBKB)
PHI: 
102100562(IKBKB)
FPG: 
101922064(IKBKB)
FCH: 
102058892(IKBKB)
CLV: 
102087238(IKBKB)
ASN: 
102377560(IKBKB)
AMJ: 
102561191(IKBKB)
PSS: 
102454676(IKBKB)
CMY: 
102932073(IKBKB)
ACS: 
100551699(ikbkb)
PBI: 
103052688(IKBKB)
XLA: 
432200(ikbkb)
XTR: 
448125(ikbkb)
DRE: 
563560(ikbkb)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
CIN: 
778921(ikk-alpha/beta)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsim_GD20310(Dsim_ird5)
DWI: 
DYA: 
Dyak_GE26340(Dyak_ird5)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
NVI: 
TCA: 
BMOR: 
PHU: 
ISC: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Solt LA, May MJ
  Title
The IkappaB kinase complex: master regulator of NF-kappaB signaling.
  Journal
Immunol Res 42:3-18 (2008)
Reference
  Authors
O'Neill LA
  Title
Counter-regulation in the IKK family.
  Journal
Biochem J 434:e1-2 (2011)

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