KEGG   ORTHOLOGY: K07209Help
Entry
K07209                      KO                                     

Name
IKBKB, IKKB
Definition
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Pathway
Antifolate resistance
MAPK signaling pathway
Ras signaling pathway
Chemokine signaling pathway
NF-kappa B signaling pathway
FoxO signaling pathway
mTOR signaling pathway
PI3K-Akt signaling pathway
Apoptosis
Osteoclast differentiation
Toll-like receptor signaling pathway
NOD-like receptor signaling pathway
RIG-I-like receptor signaling pathway
Cytosolic DNA-sensing pathway
Toll and Imd signaling pathway
IL-17 signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
T cell receptor signaling pathway
B cell receptor signaling pathway
TNF signaling pathway
Neurotrophin signaling pathway
Insulin signaling pathway
Adipocytokine signaling pathway
Type II diabetes mellitus
Insulin resistance
Non-alcoholic fatty liver disease (NAFLD)
Epithelial cell signaling in Helicobacter pylori infection
Shigellosis
Chagas disease (American trypanosomiasis)
Toxoplasmosis
Hepatitis C
Hepatitis B
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
MicroRNAs in cancer
Pancreatic cancer
Prostate cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Small cell lung cancer
Fluid shear stress and atherosclerosis
Module
M00686  
Toll-like receptor signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04014 Ras signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04010 MAPK signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04064 NF-kappa B signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04668 TNF signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04068 FoxO signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04151 PI3K-Akt signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04150 mTOR signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04624 Toll and Imd signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04621 NOD-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04622 RIG-I-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04623 Cytosolic DNA-sensing pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04660 T cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04658 Th1 and Th2 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04659 Th17 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04657 IL-17 signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04662 B cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04062 Chemokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Endocrine system
   04910 Insulin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04920 Adipocytokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Nervous system
   04722 Neurotrophin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Development
   04380 Osteoclast differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05206 MicroRNAs in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05212 Pancreatic cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05221 Acute myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05220 Chronic myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05215 Prostate cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05222 Small cell lung cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Endocrine and metabolic diseases
   04930 Type II diabetes mellitus
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04931 Insulin resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Infectious diseases
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05131 Shigellosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05166 HTLV-I infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05164 Influenza A
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05161 Hepatitis B
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05160 Hepatitis C
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05168 Herpes simplex infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05169 Epstein-Barr virus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05165 Human papillomavirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05145 Toxoplasmosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05142 Chagas disease (American trypanosomiasis)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  Drug resistance
   01523 Antifolate resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00686  Toll-like receptor signaling
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Other group
  IKK family [OT]
   K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3551(IKBKB)
PTR: 
472749(IKBKB)
PPS: 
100989390(IKBKB)
GGO: 
101141659(IKBKB)
PON: 
100440586(IKBKB)
NLE: 
100588081(IKBKB)
MCC: 
704683(IKBKB)
MCF: 
102146604(IKBKB)
CSAB: 
103215686(IKBKB)
RRO: 
104666046(IKBKB)
CJC: 
100393096(IKBKB)
SBQ: 
101052971(IKBKB)
MMU: 
16150(Ikbkb)
RNO: 
84351(Ikbkb)
CGE: 
100750488(Ikbkb)
NGI: 
103726621(Ikbkb)
HGL: 
101711077(Ikbkb)
OCU: 
100356401(IKBKB)
TUP: 
102467954(IKBKB)
CFA: 
482839(IKBKB)
AML: 
100471679(IKBKB)
UMR: 
103677059(IKBKB)
FCA: 
100142682(IKBKB)
PTG: 
102963734(IKBKB)
AJU: 
106990012(IKBKB)
BTA: 
281854(IKBKB)
BOM: 
102281443(IKBKB)
PHD: 
102337166(IKBKB)
CHX: 
102177406(IKBKB)
OAS: 
780484(IKBKB)
SSC: 
100101471(IKBKB)
CFR: 
102508142(IKBKB)
BACU: 
103015119(IKBKB)
LVE: 
103088633(IKBKB)
ECB: 
100050167(IKBKB)
MYB: 
102261405(IKBKB)
MYD: 
102773824(IKBKB)
HAI: 
109386279(IKBKB)
PALE: 
102893261(IKBKB)
LAV: 
100657363(IKBKB)
MDO: 
100033031(IKBKB)
SHR: 
100928932(IKBKB)
OAA: 
100078925(IKBKB)
GGA: 
107054958(IKBKB) 426792(IKBKB)
MGP: 
100542558(IKBKB)
CJO: 
107323740(IKBKB)
APLA: 
101790255(IKBKB)
TGU: 
100225072(IKBKB)
GFR: 
102035648(IKBKB)
FAB: 
101809821(IKBKB)
PHI: 
102100562(IKBKB)
CCW: 
104694916(IKBKB)
FPG: 
101922064(IKBKB)
FCH: 
102058892(IKBKB)
CLV: 
102087238(IKBKB)
AAM: 
106487776(IKBKB)
ASN: 
102377560(IKBKB)
AMJ: 
102561936(IKBKB)
PSS: 
102454676(IKBKB)
CMY: 
102932073(IKBKB)
CPIC: 
101945515(IKBKB)
ACS: 
100551699(ikbkb)
PBI: 
103052688(IKBKB)
GJA: 
107107812(IKBKB)
XLA: 
432200(ikbkb.L)
XTR: 
448125(ikbkb)
DRE: 
563560(ikbkb)
IPU: 
108265675(ikbkb)
TRU: 
101062431(ikbkb)
TNG: 
LCO: 
104921662(ikbkb)
MZE: 
101472803(ikbkb)
OLA: 
101170684(ikbkb)
XMA: 
102223773(ikbkb)
SASA: 
106580426(ikbkb)
LCM: 
CMK: 
CIN: 
778921(ikk-alpha/beta)
DME: 
Dmel_CG4201(IKKbeta)
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20310(Dsim_ird5)
DWI: 
DYA: 
Dyak_GE26340(Dyak_ird5)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
726760(GB18611)
BIM: 
BTER: 
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
DPL: 
PXY: 
PHU: 
DPX: 
ISC: 
OBI: 
ADF: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC
  Title
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
  Journal
Cell 117:225-37 (2004)
DOI:10.1016/S0092-8674(04)00302-2
  Sequence
[hsa:3551]
Reference
PMID:9346485
  Authors
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV
  Title
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
  Journal
Science 278:866-9 (1997)
DOI:10.1126/science.278.5339.866
  Sequence
[hsa:3551]

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