KEGG   ORTHOLOGY: K07438Help
Entry
K07438                      KO                                     

Name
CYP27B
Definition
calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
Pathway
Steroid biosynthesis
Tuberculosis
Module
M00103  
Cholecalciferol biosynthesis
Disease
H00408  
Type I diabetes mellitus
H01143  
Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00100 Steroid biosynthesis
    K07438  CYP27B; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
 Human Diseases
  Infectious diseases
   05152 Tuberculosis
    K07438  CYP27B; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00103  Cholecalciferol biosynthesis
     K07438  CYP27B; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.18  calcidiol 1-monooxygenase
     K07438  CYP27B; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP27 family
   K07438  CYP27B; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
BRITE hierarchy
Other DBs
Genes
HSA: 
1594(CYP27B1)
PTR: 
452027(CYP27B1)
PPS: 
GGO: 
PON: 
NLE: 
MCC: 
715747(CYP27B1)
MCF: 
CSAB: 
103238591(CYP27B1)
RRO: 
CJC: 
100388588(CYP27B1)
SBQ: 
MMU: 
13115(Cyp27b1)
RNO: 
114700(Cyp27b1)
CGE: 
NGI: 
HGL: 
OCU: 
TUP: 
CFA: 
481133(CYP27B1)
AML: 
UMR: 
FCA: 
100750221(CYP27B1)
PTG: 
BTA: 
539630(CYP27B1)
BOM: 
PHD: 
CHX: 
OAS: 
SSC: 
397055(CYP27B1)
CFR: 
BACU: 
LVE: 
ECB: 
100034100(CYP27B1)
MYB: 
MYD: 
PALE: 
LAV: 
MDO: 
SHR: 
FAB: 
PHI: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XTR: 
448754(cyp27b1)
DRE: 
793309(cyp27b1)
TRU: 
TNG: 
MZE: 
OLA: 
XMA: 
SASA: 
LCM: 
CMK: 
SPAR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R
  Title
Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion.
  Journal
Mol Cancer Res 1:56-67 (2002)
  Sequence
[hsa:1594]

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