KEGG   ORTHOLOGY: K07532Help
Entry
K07532                      KO                                     

Name
ARHGEF12, LARG
Definition
Rho guanine nucleotide exchange factor 12
Pathway
Vascular smooth muscle contraction
Axon guidance
Platelet activation
Regulation of actin cytoskeleton
Tuberculosis
Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
 Organismal Systems
  Immune system
   04611 Platelet activation
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  Circulatory system
   04270 Vascular smooth muscle contraction
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  Development
   04360 Axon guidance
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  Infectious diseases
   05152 Tuberculosis
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
23365(ARHGEF12)
PTR: 
451618(ARHGEF12)
PPS: 
100981550(ARHGEF12)
GGO: 
101150763(ARHGEF12)
PON: 
100457621(ARHGEF12)
MCC: 
712096(ARHGEF12)
MCF: 
102118758(ARHGEF12)
MMU: 
69632(Arhgef12)
RNO: 
367072(Arhgef12)
CGE: 
100765006(Arhgef12)
HGL: 
101716885(Arhgef12)
TUP: 
102469549(ARHGEF12)
CFA: 
479409(ARHGEF12)
AML: 
100471078(ARHGEF12)
FCA: 
101085657(ARHGEF12)
PTG: 
102949630(ARHGEF12)
BTA: 
503575(ARHGEF12)
BOM: 
102277776(ARHGEF12)
PHD: 
102329916(ARHGEF12)
CHX: 
102179302(ARHGEF12)
SSC: 
100523324(ARHGEF12)
CFR: 
102524302(ARHGEF12)
BACU: 
103002190(ARHGEF12)
LVE: 
103083833(ARHGEF12)
ECB: 
100071503(ARHGEF12)
MYB: 
102243603(ARHGEF12)
MYD: 
102761091(ARHGEF12)
PALE: 
102879072(ARHGEF12)
MDO: 
100030904(ARHGEF12)
SHR: 
100913854(ARHGEF12)
OAA: 
100073922(ARHGEF12)
GGA: 
419752(ARHGEF12)
MGP: 
100548723(ARHGEF12)
TGU: 
100222469(ARHGEF12)
FAB: 
101809691(ARHGEF12)
PHI: 
102099232(ARHGEF12)
APLA: 
101801214(ARHGEF12)
FPG: 
101920266(ARHGEF12)
FCH: 
102057692(ARHGEF12)
CLV: 
ASN: 
102372630(ARHGEF12)
AMJ: 
102569441(ARHGEF12)
PSS: 
102463682(ARHGEF12)
CMY: 
102938930(ARHGEF12)
ACS: 
100566171(arhgef12)
PBI: 
103067299(ARHGEF12)
XLA: 
398710(arhgef12)
XTR: 
779951(arhgef12)
DRE: 
562455 571031(arhgef12)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102353846(ARHGEF12)
CMK: 
BFO: 
TSP: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Rossman KL, Der CJ, Sondek J
  Title
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors.
  Journal
Nat Rev Mol Cell Biol 6:167-80 (2005)
Reference
  Authors
Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA
  Title
Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor:  evidence for its fusion with MLL in acute myeloid leukemia.
  Journal
Proc Natl Acad Sci U S A 97:2145-50 (2000)
  Sequence
[hsa:23365]

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