KEGG   ORTHOLOGY: K07747Help
Entry
K07747                      KO                                     

Name
BACE2
Definition
beta-site APP-cleaving enzyme 2 (memapsin 1) [EC:3.4.23.45]
Pathway
Alzheimer's disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 Human Diseases
  Neurodegenerative diseases
   05010 Alzheimer's disease
    K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.23  Aspartic endopeptidases
    3.4.23.45  memapsin 1
     K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1)
Peptidases [BR:ko01002]
 Aspartic Peptidases
  Family A1: pepsin family
   K07747  BACE2; beta-site APP-cleaving enzyme 2 (memapsin 1)
BRITE hierarchy
Genes
HSA: 
25825(BACE2)
PTR: 
747819(BACE2)
PPS: 
100990201(BACE2)
GGO: 
101131488(BACE2)
PON: 
100442149(BACE2)
NLE: 
100598433(BACE2)
MCC: 
715330(BACE2)
MCF: 
102140609(BACE2)
RRO: 
104655130(BACE2)
CJC: 
100406072(BACE2)
MMU: 
56175(Bace2)
RNO: 
288227(Bace2)
CGE: 
100764950(Bace2)
NGI: 
103748454(Bace2)
HGL: 
101717943(Bace2)
OCU: 
100342092(BACE2)
TUP: 
102498668(BACE2)
CFA: 
478418(BACE2)
AML: 
100477612(BACE2)
UMR: 
103680727(BACE2)
FCA: 
101096756(BACE2)
PTG: 
102955826(BACE2)
BTA: 
534774(BACE2)
BOM: 
102272554(BACE2)
PHD: 
102317728(BACE2)
CHX: 
102187812(BACE2)
OAS: 
101102027(BACE2)
SSC: 
CFR: 
102516803(BACE2)
BACU: 
103014984(BACE2)
LVE: 
103085141(BACE2)
ECB: 
100058700(BACE2)
MYB: 
102254769(BACE2)
MYD: 
102767911(BACE2)
PALE: 
102896199(BACE2)
MDO: 
100016587(BACE2)
SHR: 
100932104(BACE2)
OAA: 
100080196(BACE2)
GGA: 
418526(BACE2)
MGP: 
100547969(BACE2)
APLA: 
101795939(BACE2)
TGU: 
100224177(BACE2)
GFR: 
102039028(BACE2)
FAB: 
101816221(BACE2)
PHI: 
102107969(BACE2)
CCW: 
104686367(BACE2)
FPG: 
101919630(BACE2)
FCH: 
102051138(BACE2)
CLV: 
102088959(BACE2)
ASN: 
102386120(BACE2)
AMJ: 
102561959(BACE2)
PSS: 
102447109(BACE2)
CMY: 
102940897(BACE2)
ACS: 
100552914(bace2)
PBI: 
103059516(BACE2)
XLA: 
380307(bace2) 398806(bace2)
XTR: 
100216145(bace2)
DRE: 
TRU: 
101078612(bace2)
MZE: 
101466632(bace2)
OLA: 
101167562(bace2)
XMA: 
LCM: 
102362842(BACE2)
CMK: 
103187270(bace2)
ISC: 
PIF: 
PSOJ: 
SPAR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hussain I, Powell DJ, Howlett DR, Chapman GA, Gilmour L, Murdock PR, Tew DG, Meek TD, Chapman C, Schneider K, Ratcliffe SJ, Tattersall D, Testa TT, Southan C, Ryan DM, Simmons DL, Walsh FS, Dingwall C, Christie G
  Title
ASP1 (BACE2) cleaves the amyloid precursor protein at the beta-secretase site.
  Journal
Mol Cell Neurosci 16:609-19 (2000)

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