KEGG   ORTHOLOGY: K07750Help
Entry
K07750                      KO                                     

Name
MESO1, ERG25
Definition
methylsterol monooxygenase [EC:1.14.18.9]
Pathway
ko00100  Steroid biosynthesis
ko01100  Metabolic pathways
ko01130  Biosynthesis of antibiotics
Module
M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
Disease
H00269  Primary microcephaly (MCPH)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00100 Steroid biosynthesis
    K07750  MESO1, ERG25; methylsterol monooxygenase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00101  Cholesterol biosynthesis, squalene 2,3-epoxide => cholesterol
     K07750  MESO1, ERG25; methylsterol monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.9  methylsterol monooxygenase
     K07750  MESO1, ERG25; methylsterol monooxygenase
BRITE hierarchy
Other DBs
RN: R07509 R10057
COG: COG3000
GO: 0000254
Genes
HSA: 6307(MSMO1)
PTR: 738493(MSMO1)
PPS: 100986460(MSMO1)
GGO: 101135163(MSMO1)
PON: 100173838(MSMO1)
NLE: 100603031(MSMO1)
MCC: 705106(MSMO1)
MCF: 101865422(MSMO1)
CSAB: 103236486(MSMO1)
RRO: 104663423(MSMO1)
RBB: 108521935(MSMO1)
CJC: 100398666(MSMO1)
SBQ: 101053419(MSMO1)
MMU: 66234(Msmo1)
RNO: 140910(Msmo1)
CGE: 100754784(Msmo1)
NGI: 103732786(Msmo1)
HGL: 101719361(Msmo1)
CCAN: 109687904(Msmo1)
OCU: 100343167(MSMO1)
TUP: 102495765(MSMO1)
CFA: 475491(MSMO1)
AML: 100478610(MSMO1)
UMR: 103658127(MSMO1)
ORO: 101384837(MSMO1)
FCA: 101096978(MSMO1)
PTG: 102957399(MSMO1)
AJU: 106967462(MSMO1)
BTA: 504481(MSMO1)
BOM: 102279364(MSMO1)
BIU: 109571212(MSMO1)
PHD: 102324474(MSMO1)
CHX: 102180413(MSMO1)
OAS: 101121628(MSMO1)
SSC: 396590(MSMO1)
CFR: 102519347(MSMO1)
CDK: 105087398(MSMO1)
BACU: 103002999(MSMO1)
LVE: 103089686(MSMO1)
OOR: 101289371(MSMO1)
ECB: 100061552(MSMO1)
EPZ: 103567419(MSMO1)
EAI: 106837736(MSMO1)
MYB: 102263681(MSMO1)
MYD: 102755773(MSMO1)
HAI: 109386939(MSMO1)
RSS: 109454222(MSMO1)
PALE: 102896965(MSMO1)
LAV: 100673402
TMU: 101361066
MDO: 100015712(MSMO1)
OAA: 100075041(MSMO1)
GGA: 422423(MSMO1)
MGP: 100550538(MSMO1)
CJO: 107313018(MSMO1)
APLA: 101804996(MSMO1)
ACYG: 106032325(MSMO1)
TGU: 100222623(MSMO1)
GFR: 102040644(MSMO1)
FAB: 101811763(MSMO1)
PHI: 102111371(MSMO1)
PMAJ: 107203507(MSMO1)
CCW: 104690530(MSMO1)
FPG: 101914205(MSMO1)
FCH: 102050992(MSMO1)
CLV: 102086288(MSMO1)
EGZ: 104124048(MSMO1)
AAM: 106484071(MSMO1)
ASN: 102373382(MSMO1)
AMJ: 102570191(MSMO1)
PSS: 102449794(MSMO1)
CMY: 102930070(MSMO1)
CPIC: 101942968(MSMO1)
ACS: 100552150(msmo1)
PVT: 110083492(MSMO1)
GJA: 107116888(MSMO1)
XLA: 108704957(msmo1.L) 108706637(msmo1.S)
XTR: 780270(msmo1)
NPR: 108788887(MSMO1)
DRE: 406662(msmo1)
SRX: 107750426
SANH: 107655978
SGH: 107548349
CCAR: 109046545
IPU: 100304913(msmo1)
AMEX: 103040405(msmo1)
TRU: 101070460(msmo1)
LCO: 104933866(msmo1)
MZE: 101479801(msmo1)
OLA: 105354476(msmo1)
XMA: 102232647(msmo1)
PRET: 103460529(msmo1)
NFU: 107374119(msmo1)
CSEM: 103384085(msmo1)
LCF: 108893083(msmo1)
HCQ: 109511157(msmo1)
BPEC: 110167589(msmo1)
SASA: 106590825(msmo1)
ELS: 105008532(msmo1)
SFM: 108924344(msmo1)
CMK: 103183717(msmo1)
SPU: 582397
APLC: 110977365
DME: Dmel_CG11162(CG11162)
AAG: 5567791
AME: 727357
LAK: 106176186
SCE: YGR060W(ERG25)
CAL: CAALFM_C401530CA(ERG251) CAALFM_CR02370WA(ERG25)
NCR: NCU06402
ANG: ANI_1_798034(An03g06410)
SPO: SPAC630.08c(erg25)
CNE: CNC02410
MGL: MGL_0756
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7228857
  Authors
Fukushima H, Grinstead GF, Gaylor JL
  Title
Total enzymic synthesis of cholesterol from lanosterol. Cytochrome b5-dependence of 4-methyl sterol oxidase.
  Journal
J Biol Chem 256:4822-6 (1981)
Reference
PMID:8505296
  Authors
Pascal S, Taton M, Rahier A
  Title
Plant sterol biosynthesis. Identification and characterization of two distinct microsomal oxidative enzymatic systems involved in sterol C4-demethylation.
  Journal
J Biol Chem 268:11639-54 (1993)
Reference
PMID:8552601
  Authors
Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R
  Title
Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.
  Journal
Proc Natl Acad Sci U S A 93:186-90 (1996)
DOI:10.1073/pnas.93.1.186
Reference
PMID:8663358
  Authors
Li L, Kaplan J
  Title
Characterization of yeast methyl sterol oxidase (ERG25) and identification of a human homologue.
  Journal
J Biol Chem 271:16927-33 (1996)
  Sequence
[hsa:6307] [sce:YGR060W]

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