KEGG   ORTHOLOGY: K08045Help
Entry
K08045                      KO                                     

Name
ADCY5
Definition
adenylate cyclase 5 [EC:4.6.1.1]
Pathway
ko00230  Purine metabolism
ko01522  Endocrine resistance
ko04015  Rap1 signaling pathway
ko04022  cGMP-PKG signaling pathway
ko04024  cAMP signaling pathway
ko04062  Chemokine signaling pathway
ko04072  Phospholipase D signaling pathway
ko04114  Oocyte meiosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04261  Adrenergic signaling in cardiomyocytes
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04611  Platelet activation
ko04713  Circadian entrainment
ko04714  Thermogenesis
ko04723  Retrograde endocannabinoid signaling
ko04724  Glutamatergic synapse
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04727  GABAergic synapse
ko04728  Dopaminergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04911  Insulin secretion
ko04912  GnRH signaling pathway
ko04913  Ovarian steroidogenesis
ko04914  Progesterone-mediated oocyte maturation
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04918  Thyroid hormone synthesis
ko04921  Oxytocin signaling pathway
ko04923  Regulation of lipolysis in adipocytes
ko04924  Renin secretion
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing's syndrome
ko04970  Salivary secretion
ko04971  Gastric acid secretion
ko04972  Pancreatic secretion
ko04976  Bile secretion
ko05012  Parkinson's disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05032  Morphine addiction
ko05034  Alcoholism
ko05166  HTLV-I infection
ko05200  Pathways in cancer
ko05414  Dilated cardiomyopathy (DCM)
Module
M00695  cAMP signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Nucleotide metabolism
   00230 Purine metabolism
    K08045  ADCY5; adenylate cyclase 5
 Environmental Information Processing
  Signal transduction
   04015 Rap1 signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04371 Apelin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04072 Phospholipase D signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04024 cAMP signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04022 cGMP - PKG signaling pathway
    K08045  ADCY5; adenylate cyclase 5
 Cellular Processes
  Cell growth and death
   04114 Oocyte meiosis
    K08045  ADCY5; adenylate cyclase 5
  Cellular community - eukaryotes
   04540 Gap junction
    K08045  ADCY5; adenylate cyclase 5
 Organismal Systems
  Immune system
   04611 Platelet activation
    K08045  ADCY5; adenylate cyclase 5
   04062 Chemokine signaling pathway
    K08045  ADCY5; adenylate cyclase 5
  Endocrine system
   04911 Insulin secretion
    K08045  ADCY5; adenylate cyclase 5
   04923 Regulation of lipolysis in adipocyte
    K08045  ADCY5; adenylate cyclase 5
   04912 GnRH signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04913 Ovarian Steroidogenesis
    K08045  ADCY5; adenylate cyclase 5
   04915 Estrogen signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04914 Progesterone-mediated oocyte maturation
    K08045  ADCY5; adenylate cyclase 5
   04921 Oxytocin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04926 Relaxin signaling pathway
    K08045  ADCY5; adenylate cyclase 5
   04918 Thyroid hormone synthesis
    K08045  ADCY5; adenylate cyclase 5
   04928 Parathyroid hormone synthesis, secretion and action
    K08045  ADCY5; adenylate cyclase 5
   04916 Melanogenesis
    K08045  ADCY5; adenylate cyclase 5
   04924 Renin secretion
    K08045  ADCY5; adenylate cyclase 5
   04925 Aldosterone synthesis and secretion
    K08045  ADCY5; adenylate cyclase 5
   04927 Cortisol synthesis and secretion
    K08045  ADCY5; adenylate cyclase 5
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08045  ADCY5; adenylate cyclase 5
   04270 Vascular smooth muscle contraction
    K08045  ADCY5; adenylate cyclase 5
  Digestive system
   04970 Salivary secretion
    K08045  ADCY5; adenylate cyclase 5
   04971 Gastric acid secretion
    K08045  ADCY5; adenylate cyclase 5
   04972 Pancreatic secretion
    K08045  ADCY5; adenylate cyclase 5
   04976 Bile secretion
    K08045  ADCY5; adenylate cyclase 5
  Nervous system
   04724 Glutamatergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04727 GABAergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04725 Cholinergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04728 Dopaminergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04726 Serotonergic synapse
    K08045  ADCY5; adenylate cyclase 5
   04723 Retrograde endocannabinoid signaling
    K08045  ADCY5; adenylate cyclase 5
  Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K08045  ADCY5; adenylate cyclase 5
  Aging
   04211 Longevity regulating pathway - mammal
    K08045  ADCY5; adenylate cyclase 5
   04213 Longevity regulating pathway - multiple species
    K08045  ADCY5; adenylate cyclase 5
  Environmental adaptation
   04713 Circadian entrainment
    K08045  ADCY5; adenylate cyclase 5
   04714 Thermogenesis
    K08045  ADCY5; adenylate cyclase 5
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K08045  ADCY5; adenylate cyclase 5
  Neurodegenerative diseases
   05012 Parkinson's disease
    K08045  ADCY5; adenylate cyclase 5
  Substance dependence
   05030 Cocaine addiction
    K08045  ADCY5; adenylate cyclase 5
   05031 Amphetamine addiction
    K08045  ADCY5; adenylate cyclase 5
   05032 Morphine addiction
    K08045  ADCY5; adenylate cyclase 5
   05034 Alcoholism
    K08045  ADCY5; adenylate cyclase 5
  Cardiovascular diseases
   05414 Dilated cardiomyopathy (DCM)
    K08045  ADCY5; adenylate cyclase 5
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K08045  ADCY5; adenylate cyclase 5
  Infectious diseases
   05166 HTLV-I infection
    K08045  ADCY5; adenylate cyclase 5
  Drug resistance
   01522 Endocrine resistance
    K08045  ADCY5; adenylate cyclase 5
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00695  cAMP signaling
     K08045  ADCY5; adenylate cyclase 5
Enzymes [BR:ko01000]
 4. Lyases
  4.6  Phosphorus-oxygen lyases
   4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)
    4.6.1.1  adenylate cyclase
     K08045  ADCY5; adenylate cyclase 5
BRITE hierarchy
Other DBs
RN: R00089 R00434
GO: 0004016
Genes
HSA: 111(ADCY5)
PTR: 470905(ADCY5)
PPS: 100989177(ADCY5)
GGO: 101150181(ADCY5)
PON: 100454138(ADCY5)
NLE: 100580455(ADCY5)
MCC: 715897(ADCY5)
MCF: 102135142(ADCY5)
CSAB: 103228169(ADCY5)
RRO: 104655411 104668142(ADCY5)
RBB: 108517430(ADCY5)
CJC: 100412782(ADCY5)
SBQ: 101049747(ADCY5)
MMU: 224129(Adcy5)
RNO: 64532(Adcy5)
CGE: 100765958(Adcy5)
NGI: 103741989(Adcy5)
HGL: 101702436(Adcy5)
CCAN: 109701078(Adcy5)
OCU: 100009315(ADCY5)
TUP: 102490639(ADCY5)
CFA: 403859(ADCY5)
AML: 100482519(ADCY5)
UMR: 103678826(ADCY5)
ORO: 101380824(ADCY5)
FCA: 101100749(ADCY5)
PTG: 102969833(ADCY5)
AJU: 106984082(ADCY5)
BTA: 505740(ADCY5)
BOM: 102276460(ADCY5)
BIU: 109555842(ADCY5)
PHD: 102343137(ADCY5)
CHX: 102189798(ADCY5)
SSC: 100155970(ADCY5)
CFR: 102503785(ADCY5)
CDK: 105090284(ADCY5)
BACU: 103006764(ADCY5)
LVE: 103091169(ADCY5)
OOR: 101283178(ADCY5)
ECB: 100070498(ADCY5)
EPZ: 103563830(ADCY5)
EAI: 106823728(ADCY5)
MYB: 102257731(ADCY5)
MYD: 102760678(ADCY5)
HAI: 109387200(ADCY5)
RSS: 109451056(ADCY5)
PALE: 102897495(ADCY5)
LAV: 100670244(ADCY5)
TMU: 101346041
MDO: 100019274(ADCY5)
SHR: 100929558(ADCY5)
GGA: 395340(ADCY5)
MGP: 100547372(ADCY5)
CJO: 107316827(ADCY5)
APLA: 101794067(ADCY5) 106016417
ACYG: 106029894(ADCY5)
TGU: 100220777(ADCY5)
GFR: 102031760(ADCY5)
FAB: 101807084(ADCY5)
PHI: 102107286(ADCY5)
PMAJ: 107207500(ADCY5)
CCW: 104694019(ADCY5)
FPG: 101922323(ADCY5)
FCH: 102049855(ADCY5)
CLV: 102085466(ADCY5)
EGZ: 104128107(ADCY5)
AAM: 106499045(ADCY5)
ASN: 102383230 102387635(ADCY5)
AMJ: 102562224(ADCY5)
PSS: 102461993(ADCY5)
CMY: 102937309(ADCY5)
CPIC: 101950146(ADCY5)
ACS: 100558125(adcy5)
PVT: 110083012(ADCY5)
PBI: 103060584(ADCY5)
GJA: 107112566(ADCY5) 107113906
XTR: 100490464
NPR: 108801019 108802345(ADCY5)
DRE: 562619(adcy5)
IPU: 108266230(adcy5)
AMEX: 103026414(adcy5)
TRU: 101070040(adcy5)
LCO: 104918228(adcy5)
NCC: 104945069
MZE: 101480556(adcy5)
OLA: 101174709(adcy5)
XMA: 102229859(adcy5)
PRET: 103478500(adcy5)
NFU: 107389655(adcy5)
CSEM: 103391879(adcy5)
LCF: 108897108(adcy5)
HCQ: 109521852
BPEC: 110156638(adcy5)
SASA: 106582348(adcy5) 106586396
ELS: 105016121(adcy5)
LCM: 102353581(ADCY5)
CMK: 103188681 103189036(adcy5)
CIN: 778532(rut)
SPU: 582776
APLC: 110979349
SKO: 100376780
AME: 726514
BIM: 100747315
BTER: 100645307
SOC: 105204551
AEC: 105154476
ACEP: 105621266
PBAR: 105430765
HST: 105191454
CFO: 105258714
LHU: 105679715
PGC: 109857578
TCA: 659486
DPA: 109540307
BMOR: 101739615
PMAC: 106715905
PRAP: 111003341
PXY: 105387103
API: 100160451
DNX: 107169163
ZNE: 110830589
FCD: 110843276
DPX: DAPPUDRAFT_39757(Adcy1)
CRG: 105346394
MYI: 110463711
LAK: 106171289
EPA: 110245505
ADF: 107356750
HMG: 100210301
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ludwig MG, Seuwen K
  Title
Characterization of the human adenylyl cyclase gene family: cDNA, gene structure, and tissue distribution of the nine isoforms.
  Journal
J Recept Signal Transduct Res 22:79-110 (2002)
DOI:10.1081/RRS-120014589
  Sequence
[hsa:111]
Reference
  Authors
Ding Q, Gros R, Gray ID, Taussig R, Ferguson SS, Feldman RD
  Title
Raf kinase activation of adenylyl cyclases: isoform-selective regulation.
  Journal
Mol Pharmacol 66:921-8 (2004)
DOI:10.1124/mol.66.4.921

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