KEGG   ORTHOLOGY: K08155Help
Entry
K08155                      KO                                     

Name
SLC18A1_2, VMAT
Definition
MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Pathway
Synaptic vesicle cycle
Serotonergic synapse
Dopaminergic synapse
Parkinson's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
Brite
KEGG Orthology (KO) [BR:ko00001]
 Organismal Systems
  Nervous system
   04728 Dopaminergic synapse
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   04726 Serotonergic synapse
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   04721 Synaptic vesicle cycle
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 Human Diseases
  Neurodegenerative diseases
   05012 Parkinson's disease
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
  Substance dependence
   05030 Cocaine addiction
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   05031 Amphetamine addiction
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
   05034 Alcoholism
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
Transporters [BR:ko02000]
 Solute Carrier Family (SLC)
  SLC18: Vesicular amine transporter
   K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
 Major Facilitator Superfamily (MFS)
  Drug transporters
   Drug:H+ antiporter-1 (12 spanner) (DHA1) family
    K08155  SLC18A1_2, VMAT; MFS transporter, DHA1 family, solute carrier family 18 (vesicular amine transporter), member 1/2
BRITE hierarchy
Other DBs
Genes
HSA: 
6570(SLC18A1) 6571(SLC18A2)
PTR: 
464032(SLC18A1) 466213(SLC18A2) 749637(SLC18A1)
PPS: 
100967958(SLC18A2) 100986598(SLC18A1)
GGO: 
101124622(SLC18A1) 101132348(SLC18A2)
PON: 
NLE: 
100586312(SLC18A2) 100592997(SLC18A1)
MCC: 
701133(SLC18A2) 705489(SLC18A1)
MCF: 
102119311(SLC18A2) 102131054(SLC18A1)
CJC: 
100395730(SLC18A2) 100405909(SLC18A1)
MMU: 
110877(Slc18a1) 214084(Slc18a2)
RNO: 
25549(Slc18a2) 25693(Slc18a1)
CGE: 
100755842(Slc18a1) 100774860(Slc18a2)
NGI: 
103729298(Slc18a2) 103747655(Slc18a1)
HGL: 
101703356(Slc18a1) 101725597(Slc18a2)
OCU: 
100340936(SLC18A1) 100351780(SLC18A2)
TUP: 
102492742(SLC18A1) 102494965(SLC18A2)
CFA: 
486138(SLC18A1) 486908(SLC18A2)
AML: 
100463950(SLC18A1) 100473870(SLC18A2)
UMR: 
103657567(SLC18A2) 103676704(SLC18A1)
FCA: 
101086507(SLC18A2) 101094843(SLC18A1)
PTG: 
102970532(SLC18A2) 102970567(SLC18A1)
BTA: 
282471(SLC18A2) 617708(SLC18A1)
BOM: 
102267806 102271632(SLC18A2) 102274678(SLC18A1)
PHD: 
102337025(SLC18A2) 102342360(SLC18A1)
CHX: 
102187453(SLC18A2) 102190515(SLC18A1)
OAS: 
101104796(SLC18A2) 101121491(SLC18A1)
SSC: 
100154435(SLC18A1) 100154950(SLC18A2)
CFR: 
102523059(SLC18A1) 102523925(SLC18A2)
BACU: 
103000979(SLC18A2) 103003968(SLC18A1)
LVE: 
103075046(SLC18A2) 103084206(SLC18A1)
ECB: 
100055485(SLC18A1) 100058805(SLC18A2)
MYB: 
102246774(SLC18A1) 102248380(SLC18A2)
MYD: 
102757123(SLC18A1) 102764776(SLC18A2)
PALE: 
102892885(SLC18A1) 102896474(SLC18A2)
MDO: 
100020699(SLC18A2) 100033069(SLC18A1)
SHR: 
100916325(SLC18A2) 100933876(SLC18A1)
OAA: 
100073866(SLC18A1) 100081376(SLC18A2)
GGA: 
423921(SLC18A2) 431330(SLC18A1)
MGP: 
100544735(SLC18A1) 100550038(SLC18A2)
APLA: 
101802757(SLC18A2) 101805341(SLC18A1)
TGU: 
100228266(SLC18A2)
FAB: 
101814308(SLC18A1) 101816900(SLC18A2)
PHI: 
102100715(SLC18A2) 102112959 102113147(SLC18A1)
FPG: 
101917215(SLC18A1) 101917491(SLC18A2)
FCH: 
102049236(SLC18A1) 102059762(SLC18A2)
CLV: 
102096441(SLC18A2) 102097425(SLC18A1)
ASN: 
102368779(SLC18A2) 102377559(SLC18A1)
AMJ: 
102565966(SLC18A2) 102575216(SLC18A1)
PSS: 
102458866(SLC18A2) 102464018(SLC18A1)
CMY: 
102933350(SLC18A1) 102940972(SLC18A2)
ACS: 
100555086(slc18a1) 100555672(slc18a2)
PBI: 
103057330(SLC18A2) 103062718(SLC18A1)
XLA: 
379101(slc18a1) 379730(slc18a2)
XTR: 
DRE: 
553304(slc18a2) 571483(slc18a1)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
103185206(slc18a2)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
408517(Or141)
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CBR: 
CBG14734(Cbr-cat-1)
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
GTT: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Eiden LE, Schafer MK, Weihe E, Schutz B
  Title
The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine.
  Journal
Pflugers Arch 447:636-40 (2004)
Reference
  Authors
Gasnier B
  Title
The loading of neurotransmitters into synaptic vesicles.
  Journal
Biochimie 82:327-37 (2000)

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