KEGG   ORTHOLOGY: K08601Help
Entry
K08601                      KO                                     

Name
CYLD, USLP2
Definition
ubiquitin thioesterase [EC:3.4.19.12]
Pathway
MAPK signaling pathway - fly
Osteoclast differentiation
RIG-I-like receptor signaling pathway
Disease
H00827  
Brooke-Spiegler syndrome
H00828  
Familial cylindromatosis
H00829  
Multiple familial trichoepithelioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04013 MAPK signaling pathway - fly
    K08601  CYLD, USLP2; ubiquitin thioesterase
 Organismal Systems
  Immune system
   04622 RIG-I-like receptor signaling pathway
    K08601  CYLD, USLP2; ubiquitin thioesterase
  Development
   04380 Osteoclast differentiation
    K08601  CYLD, USLP2; ubiquitin thioesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K08601  CYLD, USLP2; ubiquitin thioesterase
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C67
   K08601  CYLD, USLP2; ubiquitin thioesterase
Ubiquitin system [BR:ko04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    K08601  CYLD, USLP2; ubiquitin thioesterase
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1540(CYLD)
PTR: 
465165(CYLD)
PPS: 
100986446(CYLD)
GGO: 
101130233(CYLD)
PON: 
100171734(CYLD)
NLE: 
100591191(CYLD)
MCC: 
695652(CYLD)
MCF: 
101867233(CYLD)
RRO: 
CJC: 
100407645(CYLD)
MMU: 
74256(Cyld)
RNO: 
312937(Cyld)
CGE: 
100758070(Cyld)
NGI: 
103730125(Cyld)
HGL: 
OCU: 
100354572(CYLD)
TUP: 
102491060(CYLD)
CFA: 
611649(CYLD)
AML: 
100467467(CYLD)
UMR: 
103673798(CYLD)
FCA: 
101094641(CYLD)
PTG: 
102954153(CYLD)
BTA: 
536421(CYLD)
BOM: 
102265067(CYLD)
PHD: 
102324394(CYLD)
CHX: 
102179035(CYLD)
OAS: 
101113429(CYLD)
SSC: 
100624570(CYLD)
CFR: 
102504764(CYLD)
BACU: 
103020547(CYLD)
LVE: 
103076921(CYLD)
ECB: 
100050308(CYLD)
MYB: 
102247016(CYLD)
MYD: 
102765473(CYLD)
PALE: 
102882294(CYLD)
MDO: 
100014031(CYLD)
SHR: 
100931361(CYLD)
OAA: 
100090868(CYLD)
GGA: 
MGP: 
CJO: 
APLA: 
101792318(CYLD)
TGU: 
GFR: 
FAB: 
PHI: 
CCW: 
FPG: 
FCH: 
CLV: 
AAM: 
ASN: 
AMJ: 
102559694(CYLDL) 102564689(CYLD) 106736827(CYLD)
PSS: 
CMY: 
ACS: 
PBI: 
GJA: 
XTR: 
100144739(cyld)
DRE: 
556823(cylda) 561108(cyldl)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD22283(Dsim_GD22283)
DYA: 
Dyak_GE26174(dyak_GLEANR_974)
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
AaeL_AAEL013253(AAEL801174)
CQU: 
AME: 
410344(CYLD)
SOC: 
AEC: 
HST: 
CFO: 
NVI: 
TCA: 
BMOR: 
PHU: 
CEL: 
CBR: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
NVE: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, Hofmann B, Siebert R, Turner G, Evans DG, Schrander-Stumpel C, Beemer FA, van Den Ouweland A, Halley D, Delpech B, Cleveland MG, Leigh I, Leisti J, Rasmussen S
  Title
Identification of the familial cylindromatosis tumour-suppressor gene.
  Journal
Nat Genet 25:160-5 (2000)
  Sequence
[hsa:1540]
Reference
  Authors
Gao J, Sun L, Huo L, Liu M, Li D, Zhou J
  Title
CYLD regulates angiogenesis by mediating vascular endothelial cell migration.
  Journal
Blood 115:4130-7 (2010)
  Sequence
[hsa:1540]
Reference
  Authors
Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM
  Title
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
  Journal
Mol Cell 37:607-19 (2010)
  Sequence
[hsa:1540]

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