KEGG   ORTHOLOGY: K08601Help
Entry
K08601                      KO                                     

Name
CYLD, USLP2
Definition
ubiquitin thioesterase CYLD [EC:3.1.2.15]
Pathway
Osteoclast differentiation
RIG-I-like receptor signaling pathway
Disease
H00827  
Brooke-Spiegler syndrome
H00828  
Familial cylindromatosis
H00829  
Multiple familial trichoepithelioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Organismal Systems
  Immune system
   04622 RIG-I-like receptor signaling pathway
    K08601  CYLD, USLP2; ubiquitin thioesterase CYLD
  Development
   04380 Osteoclast differentiation
    K08601  CYLD, USLP2; ubiquitin thioesterase CYLD
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.2  Thioester hydrolases
    3.1.2.15  ubiquitin thiolesterase
     K08601  CYLD, USLP2; ubiquitin thioesterase CYLD
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C67
   K08601  CYLD, USLP2; ubiquitin thioesterase CYLD
Ubiquitin system [BR:ko04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    K08601  CYLD, USLP2; ubiquitin thioesterase CYLD
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
1540(CYLD)
PTR: 
465165(CYLD)
PPS: 
100986446(CYLD)
GGO: 
101130233(CYLD)
PON: 
100171734(CYLD)
MCC: 
695652(CYLD)
MCF: 
MMU: 
74256(Cyld)
RNO: 
312937(Cyld)
CGE: 
100758070(Cyld)
HGL: 
TUP: 
102491060(CYLD)
CFA: 
611649(CYLD)
AML: 
100467467(CYLD)
FCA: 
101094641(CYLD)
PTG: 
102954153(CYLD)
BTA: 
536421(CYLD)
BOM: 
102265067(CYLD)
PHD: 
102324394(CYLD)
CHX: 
102179035(CYLD)
SSC: 
CFR: 
102504764(CYLD)
BACU: 
103020547(CYLD)
LVE: 
103076921(CYLD)
ECB: 
100050308(CYLD)
MYB: 
102247016(CYLD)
MYD: 
102765473(CYLD)
PALE: 
102882294(CYLD)
MDO: 
100014031(CYLD)
SHR: 
100931361(CYLD)
OAA: 
100090868(CYLD)
GGA: 
MGP: 
TGU: 
100226672(CYLD)
FAB: 
PHI: 
APLA: 
FPG: 
FCH: 
CLV: 
ASN: 
AMJ: 
PSS: 
CMY: 
PBI: 
XTR: 
100144739(cyld)
DRE: 
556823(cylda) 561108
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DVI: 
AGA: 
AAG: 
CQU: 
AME: 
410344(CYLD)
NVI: 
TCA: 
BMOR: 
PHU: 
CEL: 
CBR: 
BMY: 
LOA: 
TSP: 
NVE: 
TAD: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gao J, Sun L, Huo L, Liu M, Li D, Zhou J
  Title
CYLD regulates angiogenesis by mediating vascular endothelial cell migration.
  Journal
Blood 115:4130-7 (2010)
Reference
  Authors
Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM
  Title
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
  Journal
Mol Cell 37:607-19 (2010)

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