KEGG   ORTHOLOGY: K08845Help
Entry
K08845                      KO                                     

Name
ARAF, ARAF1
Definition
A-Raf proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Pathway
ErbB signaling pathway
FoxO signaling pathway
Vascular smooth muscle contraction
Natural killer cell mediated cytotoxicity
Long-term potentiation
Serotonergic synapse
Long-term depression
Regulation of actin cytoskeleton
Insulin signaling pathway
Progesterone-mediated oocyte maturation
Alcoholism
Hepatitis C
Pathways in cancer
Proteoglycans in cancer
Colorectal cancer
Renal cell carcinoma
Pancreatic cancer
Endometrial cancer
Glioma
Prostate cancer
Melanoma
Bladder cancer
Chronic myeloid leukemia
Acute myeloid leukemia
Non-small cell lung cancer
Disease
H00523  
Noonan syndrome and related disorders
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04012 ErbB signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04068 FoxO signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 Organismal Systems
  Immune system
   04650 Natural killer cell mediated cytotoxicity
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Endocrine system
   04910 Insulin signaling pathway
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04914 Progesterone-mediated oocyte maturation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Circulatory system
   04270 Vascular smooth muscle contraction
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Nervous system
   04726 Serotonergic synapse
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04720 Long-term potentiation
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   04730 Long-term depression
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05205 Proteoglycans in cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05210 Colorectal cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05212 Pancreatic cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05214 Glioma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05221 Acute myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05220 Chronic myeloid leukemia
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05218 Melanoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05211 Renal cell carcinoma
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05219 Bladder cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05215 Prostate cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05213 Endometrial cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
   05223 Non-small cell lung cancer
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Substance dependence
   05034 Alcoholism
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
  Infectious diseases
   05160 Hepatitis C
    K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: TKL group
  RAF family [OT]
   K08845  ARAF, ARAF1; A-Raf proto-oncogene serine/threonine-protein kinase
BRITE hierarchy
Genes
HSA: 
369(ARAF)
PTR: 
100614256(ARAF)
PPS: 
100990590(ARAF)
GGO: 
PON: 
100431871(ARAF)
MCC: 
707169(ARAF)
MCF: 
MMU: 
11836(Araf)
RNO: 
64363(Araf)
CGE: 
100751432(Araf)
HGL: 
101723157(Araf)
TUP: 
102493239(ARAF)
CFA: 
491857(ARAF)
AML: 
FCA: 
101089839(ARAF)
PTG: 
102956086(ARAF)
BTA: 
540421(ARAF)
BOM: 
102285079(ARAF)
PHD: 
102320566(ARAF)
CHX: 
102169370(ARAF)
OAS: 
100305131(ARAF)
SSC: 
397601(ARAF)
CFR: 
102506774(ARAF)
BACU: 
103020975(ARAF)
LVE: 
103090018(ARAF)
ECB: 
100061212(ARAF)
MYB: 
102241454(ARAF)
MYD: 
102755690(ARAF)
PALE: 
102877877(ARAF)
MDO: 
100017615(ARAF)
SHR: 
100913901(ARAF)
OAA: 
100084423(ARAF)
PBI: 
103066155(ARAF)
XLA: 
398892(araf-a) 399056(araf-b)
DRE: 
403063(araf)
TRU: 
654307(araf)
MZE: 
OLA: 
XMA: 
LCM: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Roskoski R Jr
  Title
RAF protein-serine/threonine kinases: structure and regulation.
  Journal
Biochem Biophys Res Commun 399:313-7 (2010)

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