KEGG   ORTHOLOGY: K08857Help
Entry
K08857                      KO                                     

Name
NEK
Definition
NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]
Disease
H00511  
Short rib-polydactyly syndrome
H00537  
Nephronophthisis-medullary cystic kidney disease
Brite
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08857  NEK; NIMA (never in mitosis gene a)-related kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Other group
  NEK family
   K08857  NEK; NIMA (never in mitosis gene a)-related kinase
Protein phosphatases and associated proteins [BR:ko01009]
 Protein Ser/ Thr phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K08857  NEK; NIMA (never in mitosis gene a)-related kinase
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K08857  NEK; NIMA (never in mitosis gene a)-related kinase
BRITE hierarchy
Genes
HSA: 
10783(NEK6) 140609(NEK7) 152110(NEK10) 284086(NEK8) 341676(NEK5) 4750(NEK1) 4751(NEK2) 4752(NEK3) 6787(NEK4) 79858(NEK11) 91754(NEK9)
PTR: 
452737(NEK3) 455033(NEK8) 457714(NEK2) 460434(NEK4) 460982(NEK11) 467512(NEK9) 471345(NEK1) 736415(NEK7) 737739(NEK6) 745900(NEK10) 745999(NEK5)
PPS: 
100970397(NEK11) 100973939 100974276(NEK3) 100977113(NEK2) 100981661(NEK4) 100985352(NEK9) 100987638(NEK8) 100989416(NEK10) 100990642(NEK1) 100991410(NEK7) 100994198(NEK6)
GGO: 
PON: 
100171895(NEK5) 100173731(NEK4) 100432369(NEK1) 100432721(NEK10) 100435738(NEK11) 100444655(NEK7) 100449065(NEK6) 100451891(NEK2) 100453007(NEK3) 100459279 100461917(NEK9) 100462534(NEK8)
MCC: 
100427402(NEK6) 694345(NEK1) 695646(NEK4) 701678(NEK10) 701707(NEK9) 710127(NEK3) 710464(NEK7) 711473(NEK2) 713960(NEK5) 716323(NEK8) 717968
MCF: 
MMU: 
140859(Nek8) 18004(Nek1) 18005(Nek2) 208583(Nek11) 217718(Nek9) 23954(Nek3) 23955(Nek4) 330721(Nek5) 59125(Nek7) 59126(Nek6) 674895(Nek10)
RNO: 
114482(Nek2) 287473(Nek8) 290705(Nek1) 299204(Nek9) 305710(Nek10) 306252(Nek4) 306576(Nek3) 315978(Nek11) 360161(Nek6) 360850(Nek7) 685440(Nek5) 690209(Nek2l1)
CGE: 
HGL: 
101696587(Nek4) 101698412(Nek10) 101703746(Nek1) 101707017(Nek2) 101708450(Nek11) 101709817(Nek3) 101711997(Nek5) 101715978(Nek8) 101719779(Nek9) 101719839(Nek6)
TUP: 
102473711(NEK3) 102480186(NEK11) 102488270(NEK10) 102489588 102490785(NEK9) 102490860(NEK2) 102490951(NEK6) 102491616(NEK4) 102491752(NEK5) 102496393(NEK8) 102503130(NEK7)
CFA: 
476591(NEK4) 480008(NEK7) 480021(NEK2) 485638(NEK10) 485660(NEK11) 486058(NEK1) 490790(NEK9) 491171(NEK8) 609003(NEK6)
AML: 
FCA: 
101080747(NEK6) 101083774(NEK9) 101084837(NEK8) 101085774(NEK2) 101087091(NEK10) 101093171(NEK4) 101093327(NEK7) 101094016(NEK1) 101095192(NEK11) 101097612(NEK5)
BTA: 
100138147(NEK5) 505876(NEK3) 511455(NEK4) 515816(NEK6) 522335(NEK10) 523998(NEK2) 532332(NEK8) 534652(NEK9) 534671(NEK1) 614924(NEK11) 781355(NEK7) 789263
BOM: 
PHD: 
102317952(NEK11) 102322831(NEK4) 102326957(NEK8) 102331587(NEK6) 102331794(NEK7) 102334430(NEK10) 102335276(NEK9) 102335850(NEK3) 102337560(NEK1) 102339861(NEK5) 102344565(NEK2)
CHX: 
102169047(NEK8) 102171902(NEK7) 102171931(NEK10) 102175993(NEK11) 102179611(NEK4) 102182138(NEK6) 102183800(NEK5) 102184730(NEK9) 102187516(NEK2) 102189122(NEK1) 102191249(NEK3)
SSC: 
100152772(NEK9) 100156672(NEK5) 100513679(NEK3) 100514006(NEK8) 100514624(NEK6) 100520589(NEK1) 100521742(NEK7) 100525954(NEK4) 100622627(NEK10) 100739585(NEK11) 397258(NEK2)
CFR: 
102503842(NEK8) 102504849(NEK7) 102505374(NEK9) 102508116(NEK2) 102508686(NEK11) 102510057(NEK3) 102510287(NEK5) 102512886(NEK4) 102517052(NEK10) 102517527(NEK1) 102519174(NEK6)
ECB: 
100051334(NEK10) 100051545(NEK4) 100052419(NEK3) 100052593(NEK5) 100054759(NEK2) 100057328(NEK9) 100059451(NEK8) 100061302(NEK1) 100061722(NEK7) 100064611(NEK11) 100071002(NEK6)
MYB: 
102240356(NEK8) 102242948(NEK2) 102247306(NEK10) 102248927(NEK7) 102249725(NEK4) 102252576(NEK11) 102253072(NEK9) 102256425(NEK3) 102256962(NEK6) 102259171(NEK1) 102263040(NEK5)
MDO: 
SHR: 
100913259(NEK7) 100917015(NEK1) 100919531(NEK11) 100919641(NEK6) 100927409(NEK3) 100927602(NEK2) 100928958(NEK4) 100930392(NEK9) 100930693 100932453(NEK8) 100932720(NEK10)
OAA: 
GGA: 
100857506(NEK11) 415900(NEK4) 417101(NEK6) 417576(NEK8) 418881(NEK5) 421376(NEK2) 422433(NEK1) 424350(NEK7) 428891(NEK9) 770196(NEK3) 776071(NEK10)
MGP: 
TGU: 
100218620(NEK3) 100221990(NEK9) 100222015(NEK4) 100222443(NEK5) 100224014(NEK6) 100224810(NEK2) 100225472(NEK10) 100227435(NEK11) 100229625(NEK7) 100229879(NEK1) 100229959(NEK8)
FAB: 
101807562(NEK2) 101808886(NEK5) 101809108(NEK11) 101810131(NEK6) 101814798(NEK1) 101816073(NEK4) 101817284(NEK7) 101817428(NEK8) 101818688(NEK3) 101820660(NEK10) 101821923(NEK9)
PHI: 
102099195(NEK5) 102101142(NEK1) 102103539(NEK9) 102103915(NEK2) 102107912(NEK6) 102108320(NEK7) 102110829(NEK4) 102112876(NEK8) 102114165(NEK11) 102114711(NEK3)
APLA: 
101789958(NEK2) 101794468(NEK8) 101795060(NEK5) 101796022(NEK3) 101797316(NEK4) 101798885(NEK7) 101801421(NEK11) 101801501(NEK9) 101802634(NEK6) 101804085(NEK1) 101804905(NEK10)
FPG: 
101911989(NEK1) 101912545(NEK6) 101913368(NEK10) 101915757(NEK8) 101916375(NEK3) 101916543(NEK5) 101917597(NEK7) 101920023(NEK11) 101921364(NEK9) 101921856(NEK2) 101923813(NEK4)
FCH: 
102048718(NEK7) 102048916(NEK11) 102050035(NEK1) 102050691(NEK8) 102051609(NEK4) 102053646(NEK2) 102056741(NEK5) 102056916(NEK3) 102058370(NEK6) 102059139(NEK9) 102060105(NEK10)
CLV: 
102083948(NEK10) 102085593(NEK6) 102086210(NEK5) 102088160(NEK2) 102088438(NEK11) 102089264(NEK1) 102091014(NEK8) 102091111(NEK7) 102091673(NEK3) 102093212(NEK4) 102098286(NEK9)
ASN: 
102367920(NEK6) 102370320(NEK4) 102378461(NEK7) 102381384(NEK11) 102385561(NEK9) 102385592(NEK10) 102386195(NEK2) 102386453(NEK8) 102386517(NEK1) 102388452(NEK3) 102388857(NEK5)
PSS: 
102444868(NEK1) 102445425(NEK2) 102445572(NEK5) 102445817(NEK3) 102446217 102446794(NEK10) 102449735(NEK7) 102454391(NEK4) 102454715(NEK6) 102455300(NEK11) 102456278 102462819(NEK9)
ACS: 
XLA: 
100036860 379177(nek2) 380346(nek6) 398600(nek9) 414527(nek4) 414882(nek7) 432258(nek3) 779142(nek8)
XTR: 
100036653(nek1) 100216232(nek9) 100328980(nek2) 100486333 100489398(nek10) 100497645(nek5) 448198(nek3) 448328(nek6) 448753(nek8) 779890(nek11) 780029(nek7) 780225(nek4)
DRE: 
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102345120 102346552(NEK8) 102347554(NEK5) 102349661(NEK11) 102350772(NEK4) 102361140(NEK7) 102361458(NEK10) 102362090(NEK9) 102363802(NEK6) 102365936(NEK2) 102367432(NEK1) 102367598(NEK3)
BFO: 
CIN: 
SPU: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
AGA: 
AAG: 
CQU: 
NVI: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
CEL: 
CELE_D1044.8(nekl-4) CELE_F19H6.1(nekl-3) CELE_Y39G10AR.3(nekl-1) CELE_ZC581.1(nekl-2)
CBR: 
CBG00136(Cbr-nekl-3) CBG03977(Cbr-nekl-1) CBG05211(Cbr-nekl-4) CBG12695(Cbr-nekl-2)
BMY: 
LOA: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G54510(NEK1) AT3G04810(NEK2) AT3G12200(Nek7) AT3G20860(NEK5) AT3G44200(NEK6) AT3G63280(NEK4) AT5G28290(NEK3)
ALY: 
CRB: 
EUS: 
CIT: 
CIC: 
GMX: 
MTR: 
CAM: 
FVE: 
CSV: 
RCU: 
POP: 
VVI: 
SLY: 
SOT: 
OSA: 
DOSA: 
Os02t0590800-00(Os02g0590800) Os03t0636800-01(Os03g0636800) Os05t0440800-01(Os05g0440800) Os07t0176600-01(Os07g0176600) Os12t0604700-01(Os12g0604700)
BDI: 
SBI: 
SORBI_01g013950(SORBIDRAFT_01g013950) SORBI_02g004270(SORBIDRAFT_02g004270) SORBI_03g040800(SORBIDRAFT_03g040800) SORBI_04g024470(SORBIDRAFT_04g024470) SORBI_09g021730(SORBIDRAFT_09g021730)
ZMA: 
SITA: 
SMO: 
PPP: 
CRE: 
VCN: 
MIS: 
MPP: 
CSL: 
CVR: 
SCE: 
YAR018C(KIN3)
AGO: 
ERC: 
KLA: 
LTH: 
PPA: 
VPO: 
ZRO: 
CGR: 
NCS: 
NCAS_0E01560(NCAS0E01560)
NDI: 
NDAI_0G01760(NDAI0G01760)
TPF: 
TPHA_0H00750(TPHA0H00750)
TBL: 
TBLA_0G00820(TBLA0G00820)
TDL: 
TDEL_0D04450(TDEL0D04450)
KAF: 
KAFR_0C00920(KAFR0C00920)
DHA: 
PIC: 
PGU: 
LEL: 
CAL: 
CTP: 
CDU: 
COT: 
YLI: 
CLU: 
NCR: 
SMP: 
PAN: 
TTT: 
MTM: 
MGR: 
FGR: 
NHE: 
VAL: 
SSL: 
BFU: 
ANI: 
NFI: 
AFM: 
AOR: 
AOR_1_258094(AO090120000152)
ANG: 
ANI_1_986104(An12g08100)
AFV: 
ACT: 
PCS: 
CIM: 
CPW: 
PBL: 
URE: 
ABE: 
TVE: 
AJE: 
PNO: 
PTE: 
ZTR: 
TML: 
SPO: 
CNE: 
CNB: 
CGI: 
PPL: 
LBC: 
CCI: 
SCM: 
MGL: 
PGR: 
ECU: 
EIN: 
EHE: 
NCE: 
MBR: 
DDI: 
DPP: 
DFA: 
EHI: 
EHI_048410(562.t00002)
EDI: 
ACAN: 
PFA: 
MAL7P1.100(Pfnek-4) PFE1290w(Pfnek-2) PFL0080c(nek-3) PFL1370w(nek-1)
PFD: 
PFH: 
PYO: 
PCB: 
PBE: 
PKN: 
PVX: 
PCY: 
TAN: 
TPV: 
BBO: 
BBOV_III010080(17.m07876) BBOV_IV008300(23.m05869)
BEQ: 
CPV: 
TGO: 
TET: 
PTM: 
PIF: 
NGD: 
EHX: 
GTT: 
TBR: 
Tb10.61.2330 Tb10.70.7860 Tb927.3.3080(Tb03.27C5.650) Tb927.3.3190(Tb03.3K10.210)
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
CHY: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J
  Title
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
  Journal
J Biol Chem 278:34897-909 (2003)
Reference
  Authors
Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM
  Title
Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.
  Journal
Mol Biol Cell 16:1711-24 (2005)
Reference
  Authors
Kim S, Kim S, Rhee K
  Title
NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells.
  Journal
J Cell Sci 124:3760-70 (2011)

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