KEGG   ORTHOLOGY: K08857Help
Entry
K08857                      KO                                     

Name
NEK1_4_5
Definition
NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]
Disease
H00511  
Short rib-polydactyly syndrome
Brite
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Other group
  NEK family
   K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosome formation and ciliogenesis proteins
   Other cilium assembly proteins
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  Check point factors
   Other check point factors
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
BRITE hierarchy
Genes
HSA: 
341676(NEK5) 4750(NEK1) 6787(NEK4)
PTR: 
460434(NEK4) 471345(NEK1) 745999(NEK5)
PPS: 
100973939(NEK5) 100981661(NEK4) 100990642(NEK1)
GGO: 
PON: 
NLE: 
MCC: 
694345(NEK1) 695646(NEK4) 713960(NEK5)
MCF: 
102114802(NEK5) 102115637(NEK1) 102130430(NEK4)
CSAB: 
103214473(NEK5) 103227744(NEK4) 103236516(NEK1)
RRO: 
104653858(NEK5) 104662876(NEK1) 104663694(NEK4)
RBB: 
108519338(NEK5) 108522327(NEK4) 108522850(NEK1)
CJC: 
SBQ: 
MMU: 
18004(Nek1) 23955(Nek4) 330721(Nek5)
RNO: 
290705(Nek1) 306252(Nek4) 685440(Nek5)
CGE: 
100752822(Nek5) 100759305(Nek1) 100761888(Nek4)
NGI: 
103727139(Nek1) 103745482(Nek5) 103749012(Nek4)
HGL: 
101696587(Nek4) 101703746(Nek1) 101711997(Nek5)
CCAN: 
OCU: 
100345120(NEK5) 100346687(NEK1) 100349662(NEK4)
TUP: 
CFA: 
100683905(NEK5) 476591(NEK4) 486058(NEK1)
AML: 
100472594(NEK5) 100482924(NEK4) 100483504(NEK1)
UMR: 
103658148(NEK1) 103674753(NEK4) 103677632(NEK5)
FCA: 
101093171(NEK4) 101094016(NEK1) 101097612(NEK5)
PTG: 
102952900(NEK1) 102956539(NEK5) 102963755(NEK4)
AJU: 
BTA: 
100138147(NEK5) 511455(NEK4) 534671(NEK1)
BOM: 
102271510(NEK1) 102277016(NEK4) 102287387(NEK5)
BIU: 
109562754(NEK1) 109566748(NEK5) 109576014(NEK4)
PHD: 
102322831(NEK4) 102337560(NEK1) 102339861(NEK5)
CHX: 
102179611(NEK4) 102183800(NEK5) 102189122(NEK1)
OAS: 
101107110(NEK5) 101110544(NEK4) 101114757(NEK1)
SSC: 
100156672(NEK5) 100520589(NEK1) 106504146(NEK4)
CFR: 
102510287(NEK5) 102512886(NEK4) 102517527(NEK1)
CDK: 
105090995(NEK5) 105093308(NEK4) 105101615(NEK1)
BACU: 
LVE: 
103077466(NEK1) 103089687(NEK5) 103091092(NEK4)
ECB: 
100051545(NEK4) 100052593(NEK5) 100061302(NEK1)
EPZ: 
EAI: 
106821749(NEK4) 106837700(NEK5) 106848465(NEK1)
MYB: 
102249725(NEK4) 102259171(NEK1) 102263040(NEK5)
MYD: 
102758129(NEK1) 102764427(NEK5) 102767708(NEK4)
HAI: 
RSS: 
PALE: 
102888550(NEK1) 102893235(NEK5) 102894766(NEK4)
LAV: 
100661998(NEK4) 100665709(NEK1) 100677745(NEK5)
MDO: 
100020318(NEK4) 100021205(NEK1) 100028128(NEK5)
SHR: 
100917015(NEK1) 100928958(NEK4) 100930693(NEK5)
OAA: 
100077133(NEK1) 100082611(NEK5) 100092385(NEK4)
GGA: 
415900(NEK4) 418881(NEK5) 422433(NEK1)
MGP: 
100539213(NEK4) 100540479(NEK1) 100541238(NEK5)
CJO: 
107308186(NEK5) 107313003(NEK1) 107319539(NEK4)
APLA: 
101795060(NEK5) 101797316(NEK4) 101804085(NEK1)
ACYG: 
TGU: 
100222015(NEK4) 100222443(NEK5) 100229879(NEK1)
GFR: 
102034206(NEK1) 102038725(NEK5) 102045571(NEK4)
FAB: 
101808886(NEK5) 101814798(NEK1) 101816073(NEK4)
PHI: 
102099195(NEK5) 102101142(NEK1) 102110829(NEK4)
PMAJ: 
107202862(NEK1) 107208037(NEK5) 107210212(NEK4)
CCW: 
104683227(NEK4) 104689945(NEK5) 104690539(NEK1)
FPG: 
101911989(NEK1) 101916543(NEK5) 101923813(NEK4)
FCH: 
102050035(NEK1) 102051609(NEK4) 102056741(NEK5)
CLV: 
102086210(NEK5) 102089264(NEK1) 102093212(NEK4)
AAM: 
106482187(NEK4) 106484010(NEK1) 106489228(NEK5)
ASN: 
102370320(NEK4) 102386517(NEK1) 102388857(NEK5)
AMJ: 
102559950(NEK4) 102561351(NEK1) 102574416(NEK5)
PSS: 
102444868(NEK1) 102445572(NEK5) 102454391(NEK4)
CMY: 
102937442(NEK5) 102942101(NEK1) 102947290(NEK4)
CPIC: 
ACS: 
100552798(nek1) 100558250(nek5) 100560174(nek4)
PVT: 
110076146(NEK5) 110080625(NEK4) 110085374(NEK1)
PBI: 
GJA: 
XLA: 
108699026(nek1.L) 108706631(nek1.S) 108708675(nek5.L) 414527(nek4.S)
XTR: 
100036653(nek1) 100497645(nek5) 780225(nek4)
NPR: 
DRE: 
393987(nek4) 556002(nek1)
SRX: 
SANH: 
SGH: 
IPU: 
AMEX: 
TRU: 
101071067(nek1) 101079247(nek4)
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
103386146(nek4) 103391509(nek5) 103398921(nek1)
LCF: 
HCQ: 
109515100(nek1) 109519337(nek5) 109522630(nek4)
BPEC: 
110154880(nek1) 110162963(nek5) 110168405(nek4)
SASA: 
ELS: 
SFM: 
LCM: 
102347554(NEK5) 102350772(NEK4) 102367432(NEK1)
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
SOC: 
AEC: 
PGC: 
DPX: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
SHX: 
OVI: 
NVE: 
ADF: 
HMG: 
TAD: 
AQU: 
ATH: 
AT1G54510(NEK1) AT3G04810(NEK2) AT3G12200(Nek7) AT3G20860(NEK5) AT3G44200(NEK6) AT3G63280(NEK4) AT5G28290(NEK3)
ALY: 
CRB: 
CSAT: 
EUS: 
BRP: 
BNA: 
BOE: 
THJ: 
CIT: 
CIC: 
TCC: 
GRA: 
GHI: 
EGR: 
GMX: 
PVU: 
VRA: 
VAR: 
CCAJ: 
MTR: 
CAM: 
ADU: 
AIP: 
LJA: 
Lj0g3v0066389.1(Lj0g3v0066389.1) Lj0g3v0066389.2(Lj0g3v0066389.2) Lj0g3v0200839.1(Lj0g3v0200839.1) Lj0g3v0250989.1(Lj0g3v0250989.1) Lj0g3v0250989.2(Lj0g3v0250989.2) Lj1g3v4446980.1(Lj1g3v4446980.1) Lj1g3v4446980.2(Lj1g3v4446980.2) Lj3g3v1339050.2(Lj3g3v1339050.2) Lj5g3v1003590.1(Lj5g3v1003590.1)
LANG: 
FVE: 
PPER: 
PMUM: 
MDM: 
PXB: 
ZJU: 
CSV: 
CMO: 
MCHA: 
RCU: 
JCU: 
POP: 
POPTR_0001s05610g(POPTRDRAFT_1065868) POPTR_0001s22570g(POPTRDRAFT_172062) POPTR_0002s05020g(POPTRDRAFT_1071289) POPTR_0003s04570g POPTR_0003s20440g(POPTRDRAFT_830974) POPTR_0005s05320g POPTR_0006s05500g POPTR_0009s02520g POPTR_0013s03660g(POPTRDRAFT_241197) POPTR_0016s05240g(POPTRDRAFT_255732)
VVI: 
SLY: 
SPEN: 
SOT: 
CANN: 
NTA: 
NSY: 
NTO: 
INI: 
SIND: 
BVG: 
NNU: 
OSA: 
4324792(NEK5) 4329828(NEK6) 4333522(NEK1) 4338922(B1110B01.5)
DOSA: 
Os01t0864700-00(Os01g0864700) Os02t0590800-00(Os02g0590800) Os03t0636800-01(Os03g0636800) Os05t0440800-01(Os05g0440800) Os07t0176600-01(Os07g0176600)
OBR: 
BDI: 
ATS: 
SBI: 
ZMA: 
SITA: 
PDA: 
EGU: 
MUS: 
DCT: 
ATR: 
SMO: 
PPP: 
CRE: 
VCN: 
MNG: 
MIS: 
MPP: 
CSL: 
CVR: 
APRO: 
ERO: 
MBR: 
SRE: 
DDI: 
DPP: 
DFA: 
EIV: 
ACAN: 
TET: 
PTM: 
GSPATT00001359001 GSPATT00002156001 GSPATT00002648001 GSPATT00003168001 GSPATT00004057001 GSPATT00004059001 GSPATT00004528001 GSPATT00004846001 GSPATT00006075001 GSPATT00006314001 GSPATT00006544001 GSPATT00006615001 GSPATT00007206001 GSPATT00007337001 GSPATT00007469001 GSPATT00007491001 GSPATT00007922001 GSPATT00009645001 GSPATT00010040001 GSPATT00010043001 GSPATT00010088001 GSPATT00010535001 GSPATT00010926001 GSPATT00011110001 GSPATT00011566001 GSPATT00011696001 GSPATT00011735001 GSPATT00011739001 GSPATT00011981001 GSPATT00012141001 GSPATT00012656001 GSPATT00013343001 GSPATT00013801001 GSPATT00013847001 GSPATT00014072001 GSPATT00014310001 GSPATT00014645001 GSPATT00014673001 GSPATT00015246001 GSPATT00015703001 GSPATT00016728001 GSPATT00018290001 GSPATT00018681001 GSPATT00019232001 GSPATT00019684001 GSPATT00020577001 GSPATT00020696001 GSPATT00020820001 GSPATT00021083001 GSPATT00021876001 GSPATT00021986001 GSPATT00022183001 GSPATT00023086001 GSPATT00023871001 GSPATT00023951001 GSPATT00024078001 GSPATT00024429001 GSPATT00024859001 GSPATT00025621001 GSPATT00025833001 GSPATT00026501001 GSPATT00026737001 GSPATT00026742001 GSPATT00026879001 GSPATT00027492001 GSPATT00027741001 GSPATT00028006001 GSPATT00028035001 GSPATT00028448001 GSPATT00028739001 GSPATT00028907001 GSPATT00029408001 GSPATT00029530001 GSPATT00029552001 GSPATT00030848001 GSPATT00031802001 GSPATT00032136001 GSPATT00032301001 GSPATT00034024001 GSPATT00034623001 GSPATT00034888001 GSPATT00034968001 GSPATT00035570001 GSPATT00035630001 GSPATT00036182001 GSPATT00036483001 GSPATT00037285001 GSPATT00037737001 GSPATT00038914001
SMIN: 
v1.2.000143.t1(symbB.v1.2.000143.t1) v1.2.000530.t1(symbB.v1.2.000530.t1) v1.2.006607.t1(symbB.v1.2.006607.t1) v1.2.006607.t2(symbB.v1.2.006607.t2) v1.2.006977.t1(symbB.v1.2.006977.t1) v1.2.012484.t1(symbB.v1.2.012484.t1) v1.2.013139.t1(symbB.v1.2.013139.t1) v1.2.013647.t1(symbB.v1.2.013647.t1) v1.2.016636.t1(symbB.v1.2.016636.t1) v1.2.016636.t2(symbB.v1.2.016636.t2) v1.2.017864.t1(symbB.v1.2.017864.t1) v1.2.017920.t1(symbB.v1.2.017920.t1) v1.2.019906.t1(symbB.v1.2.019906.t1) v1.2.021594.t1(symbB.v1.2.021594.t1) v1.2.022473.t1(symbB.v1.2.022473.t1) v1.2.025880.t1(symbB.v1.2.025880.t1) v1.2.030100.t1(symbB.v1.2.030100.t1) v1.2.030155.t1(symbB.v1.2.030155.t1) v1.2.031111.t1(symbB.v1.2.031111.t1) v1.2.031698.t1(symbB.v1.2.031698.t1) v1.2.031734.t2(symbB.v1.2.031734.t2) v1.2.032085.t1(symbB.v1.2.032085.t1) v1.2.032085.t2(symbB.v1.2.032085.t2) v1.2.035378.t1(symbB.v1.2.035378.t1) v1.2.035378.t2(symbB.v1.2.035378.t2) v1.2.035378.t3(symbB.v1.2.035378.t3) v1.2.035856.t1(symbB.v1.2.035856.t1) v1.2.037791.t1(symbB.v1.2.037791.t1) v1.2.039050.t1(symbB.v1.2.039050.t1) v1.2.041526.t1(symbB.v1.2.041526.t1)
AAF: 
NGD: 
PIF: 
PSOJ: 
SPAR: 
EHX: 
GTT: 
TBR: 
TCR: 
LMA: 
LIF: 
LDO: 
LMI: 
LBZ: 
NGR: 
TVA: 
GLA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB, Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH, Rauch A
  Title
NEK1 mutations cause short-rib polydactyly syndrome type majewski.
  Journal
Am J Hum Genet 88:106-14 (2011)
DOI:10.1016/j.ajhg.2010.12.004
  Sequence
[hsa:4750]
Reference
PMID:8208544
  Authors
Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB, et al.
  Title
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
  Journal
Oncogene 9:1977-88 (1994)
  Sequence
[hsa:6787]

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