KEGG   ORTHOLOGY: K08857Help
Entry
K08857                      KO                                     
Name
NEK
Definition
NIMA (never in mitosis gene a)-related kinase [EC:2.7.11.1]
Disease
H00511  
Short rib-polydactyly syndrome
H00537  
Nephronophthisis-medullary cystic kidney disease
Brite
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08857  NEK; NIMA (never in mitosis gene a)-related kinase
Protein kinases [BR:ko01001]
 Serine/threonine protein kinases: Others
  NEK family
   K08857  NEK; NIMA (never in mitosis gene a)-related kinase
Chromosome [BR:ko03036]
 Eukaryotic Type
  Centrosomal proteins
   Kinases and associated factors
    K08857  NEK; NIMA (never in mitosis gene a)-related kinase
BRITE hierarchy
Genes
HSA: 
10783(NEK6) 140609(NEK7) 152110(NEK10) 284086(NEK8) 341676(NEK5) 4750(NEK1) 4751(NEK2) 4752(NEK3) 6787(NEK4) 79858(NEK11) 91754(NEK9)
PTR: 
452737(NEK3) 455033(NEK8) 457714(NEK2) 460434(NEK4) 460982(NEK11) 467512(NEK9) 471345(NEK1) 736415(NEK7) 737739(NEK6) 745900(NEK10) 745999(NEK5)
PPS: 
100970397(NEK11) 100973939 100974276(NEK3) 100977113(NEK2) 100981661(NEK4) 100985352(NEK9) 100987638(NEK8) 100989416(NEK10) 100990642(NEK1) 100991410(NEK7) 100994198(NEK6)
GGO: 
PON: 
100171895(NEK5) 100173731(NEK4) 100432369(NEK1) 100432721(NEK10) 100435738(NEK11) 100444655(NEK7) 100449065(NEK6) 100451891(NEK2) 100453007(NEK3) 100459279 100461917(NEK9) 100462534(NEK8)
MCC: 
100427402(NEK6) 694345(NEK1) 695646(NEK4) 701678(NEK10) 701707(NEK9) 710127(NEK3) 710464(NEK7) 711473(NEK2) 713960(NEK5) 716323(NEK8) 717968
MMU: 
140859(Nek8) 18004(Nek1) 18005(Nek2) 208583(Nek11) 217718(Nek9) 23954(Nek3) 23955(Nek4) 330721(Nek5) 59125(Nek7) 59126(Nek6) 674895(Nek10)
RNO: 
114482(Nek2) 287473(Nek8) 290705(Nek1) 299204(Nek9) 305710(Nek10) 306252(Nek4) 306576(Nek3) 315978(Nek11) 360161(Nek6) 360850(Nek7) 685440(Nek5) 690209(Nek2l1)
CFA: 
476591(NEK4) 480008(NEK7) 480021(NEK2) 485638(NEK10) 485660(NEK11) 486058(NEK1) 490790(NEK9) 491171(NEK8) 609003(NEK6)
AML: 
FCA: 
101080747(NEK6) 101083774(NEK9) 101084837(NEK8) 101085774(NEK2) 101087091(NEK10) 101093171(NEK4) 101093327(NEK7) 101094016(NEK1) 101095192(NEK11) 101097612(NEK5)
BTA: 
100138147(NEK5) 505876(NEK3) 511455(NEK4) 515816(NEK6) 522335(NEK10) 523998(NEK2) 532332(NEK8) 534652(NEK9) 534671 614924(NEK11) 781355(NEK7) 789263
SSC: 
100152772(NEK9) 100156672(NEK5) 100513679(NEK3) 100514006(NEK8) 100514624(NEK6) 100520589(NEK1) 100521742(NEK7) 100525954(NEK4) 100622627(NEK10) 100739585 397258(NEK2)
ECB: 
100051545(NEK4) 100052419(NEK3) 100052593(NEK5) 100054759(NEK2) 100057328(NEK9) 100059451(NEK8) 100061302 100061722(NEK7) 100064611(NEK11) 100071002
MDO: 
100016325(NEK2) 100018369(NEK9) 100018380 100020318 100021205(NEK1) 100024946(NEK8) 100026840 100028097(NEK3) 100028128(NEK5) 100030254(NEK11) 100031740(NEK10)
SHR: 
100913259(NEK7) 100917015(NEK1) 100919531(NEK11) 100919641(NEK6) 100927409(NEK3) 100927602(NEK2) 100928958(NEK4) 100930392(NEK9) 100930693 100932453(NEK8) 100932720(NEK10)
OAA: 
100074005 100075130 100075987(NEK10) 100077133(NEK1) 100078509 100078782 100081786(NEK8) 100082551(NEK3) 100082611(NEK5) 100083779(NEK11) 100092385(NEK4) 100092566(NEK9)
GGA: 
100857506 415900(NEK4) 417101(NEK6) 417576(NEK8) 418881(NEK5) 421376(NEK2) 422433(NEK1) 424350(NEK7) 428891(NEK9) 770196(NEK3) 776071(NEK10)
MGP: 
100538477 100539213 100540058(NEK2) 100540479(NEK1) 100541088 100541238 100542104 100543466(NEK9) 100546512 100548923
TGU: 
100218620(NEK3) 100221990(NEK9) 100222015(NEK4) 100222443(NEK5) 100224014(NEK6) 100224810(NEK2) 100225472(NEK10) 100227435(NEK11) 100229625(NEK7) 100229879(NEK1) 100229959(NEK8)
ACS: 
100552764 100552798(nek1) 100556817(nek9) 100558250 100560174 100561378 100565749(nek2)
XLA: 
100036860 379177(nek2) 380346(nek6) 398600(nek9) 414527(nek4) 414882(nek7) 432258(nek3) 779142(nek8)
XTR: 
100036653(nek1) 100216232(nek9) 100328980(nek2) 100486333 100489398(nek10) 100497645 448198(nek3) 448328(nek6) 448753(nek8) 779890(nek11) 780029(nek7) 780225(nek4)
DRE: 
100333839(nek10) 100334361 171094(nek8) 393987(nek4) 394025(nek2) 445223(nek7) 548344 556002(nek1) 557131 557475
TRU: 
101062697 101064124 101068519 101069610 101071067 101074507 101075627 101079247
OLA: 
101160722 101161178 101162253 101166349 101166661 101168418 101169778 101170580 101173323
BFO: 
BRAFLDRAFT_115429 BRAFLDRAFT_121258 BRAFLDRAFT_121964 BRAFLDRAFT_204870 BRAFLDRAFT_205444 BRAFLDRAFT_210652 BRAFLDRAFT_227132 BRAFLDRAFT_63676 BRAFLDRAFT_76429
CIN: 
100175739 100175797(nek10) 100176299 100179672 100183829 100184532 100186341(nek8)
SPU: 
575899(nek9) 576471 577477(nek1) 581714 583872 588047 591247 593493 594325 753693
DME: 
Dmel_CG10951(niki) Dmel_CG17256(Nek2)
DPO: 
Dpse_GA10662 Dpse_GA14417
DAN: 
Dana_GF18771 Dana_GF21241
DER: 
Dere_GG12317 Dere_GG17602
DPE: 
Dper_GL13858 Dper_GL14583
DSE: 
Dsec_GM11966 Dsec_GM23460
DSI: 
Dsim_GD18266
DWI: 
Dwil_GK10114 Dwil_GK13165
DYA: 
Dyak_GE10771 Dyak_GE17502
DGR: 
Dgri_GH20866 Dgri_GH24478
DMO: 
Dmoj_GI10715 Dmoj_GI11217
DVI: 
Dvir_GJ16859 Dvir_GJ23132
AGA: 
AgaP_AGAP006872
AAG: 
AaeL_AAEL009960 AaeL_AAEL011344
CQU: 
CpipJ_CPIJ018315
TCA: 
662248
API: 
100161860 100168219 100169010
PHU: 
Phum_PHUM463250
ISC: 
IscW_ISCW001885 IscW_ISCW019653
CEL: 
CELE_D1044.8(nekl-4) CELE_F19H6.1(nekl-3) CELE_Y39G10AR.3(nekl-1) CELE_ZC581.1(nekl-2)
CBR: 
CBG00136(Cbr-nekl-3) CBG03977(Cbr-nekl-1) CBG05211(Cbr-nekl-4) CBG12695(Cbr-nekl-2)
BMY: 
Bm1_31880 Bm1_55750
SMM: 
Smp_009800 Smp_097940 Smp_176970
NVE: 
NEMVE_v1g116843 NEMVE_v1g117779 NEMVE_v1g121980 NEMVE_v1g125185 NEMVE_v1g79897 NEMVE_v1g79942 NEMVE_v1g90306 NEMVE_v1g90343
HMG: 
100197495 100205637 100207286(nek8) 100212063 100213792 100213987
TAD: 
TRIADDRAFT_19228 TRIADDRAFT_20215 TRIADDRAFT_21160 TRIADDRAFT_25143 TRIADDRAFT_25231 TRIADDRAFT_28793 TRIADDRAFT_30735 TRIADDRAFT_51708
AQU: 
100638014 100638507 100639181 100639236
ATH: 
AT1G54510(NEK1) AT3G04810(NEK2) AT3G20860(NEK5) AT3G44200(NEK6) AT3G63280(NEK4) AT5G28290(NEK3)
ALY: 
ARALYDRAFT_318835 ARALYDRAFT_474726 ARALYDRAFT_477750 ARALYDRAFT_484841 ARALYDRAFT_486833 ARALYDRAFT_489646
GMX: 
100780141 100788588 100818747
MTR: 
MTR_1g071480 MTR_2g087090
CSV: 
101207766 101220506 101220901 101222412
RCU: 
RCOM_1282950 RCOM_1427830
POP: 
POPTR_1065868 POPTR_204097 POPTR_241197 POPTR_595442
VVI: 
100241803 100258125
OSA: 
4333522 4338922 4342542
DOSA: 
Os03t0636800-01(Os03g0636800) Os05t0440800-01(Os05g0440800) Os07t0176600-01(Os07g0176600)
BDI: 
100822355 100831949 100840244 100845374
SBI: 
SORBI_01g013950(SORBIDRAFT_01g013950) SORBI_02g004270(SORBIDRAFT_02g004270) SORBI_03g040800(SORBIDRAFT_03g040800) SORBI_04g024470(SORBIDRAFT_04g024470)
ZMA: 
100285649
SMO: 
SELMODRAFT_108317 SELMODRAFT_85451
PPP: 
PHYPADRAFT_69271
CRE: 
CHLREDRAFT_134455(CNK3) CHLREDRAFT_144460(CNK7) CHLREDRAFT_188335(CNK5) CHLREDRAFT_194082
VCN: 
VOLCADRAFT_55421(cnk3) VOLCADRAFT_62813(cnk5) VOLCADRAFT_69973(cnk9) VOLCADRAFT_99613
SCE: 
YAR018C(KIN3)
AGO: 
AGOS_AER222C
ERC: 
Ecym_5252
KLA: 
KLLA0C04213g
LTH: 
KLTH0E16104g
PPA: 
PAS_chr1-4_0451
VPO: 
Kpol_1037p7
ZRO: 
ZYRO0A05192g
CGR: 
CAGL0I04422g
NCS: 
NCAS_0E01560(NCAS0E01560)
NDI: 
NDAI_0G01760(NDAI0G01760)
TPF: 
TPHA_0H00750(TPHA0H00750)
TBL: 
TBLA_0G00820(TBLA0G00820)
TDL: 
TDEL_0D04450(TDEL0D04450)
KAF: 
KAFR_0C00920(KAFR0C00920)
DHA: 
DEHA2B15884g
PIC: 
PICST_79384(KIN3)
PGU: 
PGUG_02304
LEL: 
LELG_05696
CAL: 
CaO19.12785(KIN3) CaO19.5325(KIN3)
CTP: 
CTRG_01934
CDU: 
CD36_31650
COT: 
CORT_0B00280
YLI: 
YALI0E34067g
CLU: 
CLUG_05229
NCR: 
NCU03187
SMP: 
SMAC_02908
PAN: 
PODANSg4199
TTT: 
THITE_2043949
MTM: 
MYCTH_2297575
MGR: 
MGG_03026
FGR: 
FG09408.1
NHE: 
NECHADRAFT_32463
VAL: 
VDBG_01832
SSL: 
SS1G_05159
BFU: 
BC1G_11194
ANI: 
AN9504.2
NFI: 
NFIA_048980
AFM: 
AFUA_6G02670
AOR: 
AOR_1_258094(AO090120000152)
ANG: 
ANI_1_986104(An12g08100)
AFV: 
AFLA_091450
ACT: 
ACLA_097820
PCS: 
Pc22g24040
CIM: 
CIMG_10051
CPW: 
CPC735_011930
PBL: 
PAAG_04505
URE: 
UREG_05976
ABE: 
ARB_01800
TVE: 
TRV_04735
AJE: 
HCAG_05056
PNO: 
SNOG_07431
PTE: 
PTT_12804
ZTR: 
MYCGRDRAFT_41334
TML: 
GSTUM_00004671001
SPO: 
SPAC19E9.02(fin1)
CNE: 
CNI02840
CNB: 
CNBH2710
CGI: 
CGB_H5410W
PPL: 
POSPLDRAFT_20308
LBC: 
LACBIDRAFT_145454
CCI: 
CC1G_04175
SCM: 
SCHCODRAFT_70333
MGL: 
MGL_1688
PGR: 
PGTG_10104
NCE: 
NCER_100088
MBR: 
MONBRDRAFT_15013 MONBRDRAFT_19517 MONBRDRAFT_25342 MONBRDRAFT_29172 MONBRDRAFT_33972 MONBRDRAFT_38400
NGR: 
NAEGRDRAFT_29678 NAEGRDRAFT_64690 NAEGRDRAFT_69957 NAEGRDRAFT_70275(FM166)
DDI: 
DDB_G0270814(nek2) DDB_G0275241(nek3) DDB_G0283927 DDB_G0289277(nek4)
DPP: 
DICPUDRAFT_44395
EHI: 
EHI_048410(562.t00002)
EDI: 
EDI_348820
PFA: 
PFE1290w(Pfnek-2)
PFD: 
PFDG_03020 PFDG_04237
PFH: 
PFHG_02851 PFHG_03252
PYO: 
PY06724
PCB: 
PC000234.00.0 PC302433.00.0
PBE: 
PB000208.03.0 PB001094.00.0
PKN: 
PKH_031300 PKH_100620
PVX: 
PVX_079950 PVX_096360
PCY: 
PCYB_032330 PCYB_101570
TAN: 
TA06530 TA11560
TPV: 
TP02_0139
BBO: 
BBOV_III010080(17.m07876)
TGO: 
TGME49_044620 TGME49_119700
TET: 
TTHERM_00161100 TTHERM_00185750 TTHERM_00415780 TTHERM_00449170 TTHERM_00467740 TTHERM_00529780 TTHERM_01000150 TTHERM_01030010 TTHERM_01144900
PTM: 
GSPATT00003253001 GSPATT00004057001 GSPATT00010040001 GSPATT00010088001 GSPATT00011440001 GSPATT00012141001 GSPATT00016022001 GSPATT00019684001 GSPATT00026788001 GSPATT00027807001 GSPATT00034968001 GSPATT00037737001
TBR: 
Tb10.61.2330 Tb10.70.7860 Tb927.3.3080(Tb03.27C5.650) Tb927.3.3190(Tb03.3K10.210)
TCR: 
506697.30 506851.10 508153.400 508153.510 511283.280
LMA: 
LMJF_21_1565
LIF: 
LINJ_21_1870 LINJ_29_2680 LINJ_29_2780 LINJ_32_0270
LDO: 
LDBPK_211870 LDBPK_292680 LDBPK_292780 LDBPK_320270
LMI: 
LMXM_08_29_2570 LMXM_08_29_2670 LMXM_21_1565 LMXM_31_0260
LBZ: 
LBRM_21_1750 LBRM_29_2540 LBRM_29_2640 LBRM_32_0330
GLA: 
GL50803_11311 GL50803_5375 GL50803_92498
TVA: 
TVAG_024810 TVAG_025740 TVAG_048150 TVAG_210350 TVAG_370340
PIF: 
PITG_00208 PITG_03934 PITG_06964
CHY: 
CHY_1343
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Belham C, Roig J, Caldwell JA, Aoyama Y, Kemp BE, Comb M, Avruch J
  Title
A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases.
  Journal
J Biol Chem 278:34897-909 (2003)
Reference
  Authors
Hames RS, Crookes RE, Straatman KR, Merdes A, Hayes MJ, Faragher AJ, Fry AM
  Title
Dynamic recruitment of Nek2 kinase to the centrosome involves microtubules, PCM-1, and localized proteasomal degradation.
  Journal
Mol Biol Cell 16:1711-24 (2005)
Reference
  Authors
Kim S, Kim S, Rhee K
  Title
NEK7 is essential for centriole duplication and centrosomal accumulation of pericentriolar material proteins in interphase cells.
  Journal
J Cell Sci 124:3760-70 (2011)
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