KEGG   ORTHOLOGY: K09048Help
Entry
K09048                      KO                                     

Name
CREB3
Definition
cyclic AMP-responsive element-binding protein 3
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adrenergic signaling in cardiomyocytes
TNF signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin secretion
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Vasopressin-regulated water reabsorption
Huntington's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
Hepatitis B
Viral carcinogenesis
Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04024 cAMP signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04022 cGMP - PKG signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04151 PI3K-Akt signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04152 AMPK signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04915 Estrogen signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04918 Thyroid hormone synthesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04916 Melanogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Nervous system
   04725 Cholinergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04728 Dopaminergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05215 Prostate cancer
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Neurodegenerative diseases
   05016 Huntington's disease
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Substance dependence
   05030 Cocaine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05031 Amphetamine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05034 Alcoholism
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Infectious diseases
   05161 Hepatitis B
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Basic leucine zipper (bZIP)
   CREB
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
10488(CREB3) 148327(CREB3L4) 64764(CREB3L2) 84699(CREB3L3) 90993(CREB3L1)
PTR: 
451704(CREB3L1) 457341(CREB3L4) 468672(CREB3L3) 738928(CREB3L2)
PPS: 
100977358(CREB3L3) 100977804(CREB3L4) 100981063(CREB3L1) 100986194(CREB3L2) 100989680(CREB3)
GGO: 
101127253(CREB3L3) 101128609(CREB3L2) 101133101 101144135(CREB3) 101144628(CREB3L1) 101152081(CREB3L4)
PON: 
100127093(CREB3L2) 100432292(CREB3L1) 100436186(CREB3L4) 100438869(CREB3) 100441756(CREB3L3)
NLE: 
100592170(CREB3L3) 100594080(CREB3L1) 100595943(CREB3L2) 100597876(CREB3) 100603387(CREB3L4)
MCC: 
696350(CREB3) 713391 714981 715951(CREB3L4) 721825
MCF: 
102134095(CREB3L4) 102136437(CREB3L3) 102139679(CREB3) 102142378(CREB3L1) 102146405(CREB3L2)
CJC: 
100394351(CREB3L3) 100406635(CREB3L1) 100408954(CREB3) 100409637(CREB3L2) 100411140(CREB3L4)
MMU: 
12913(Creb3) 208647(Creb3l2) 208677(Creb3l3) 26427(Creb3l1) 78284(Creb3l4)
RNO: 
310616(Creb3l4) 314638(Creb3l3) 362165(Creb3l1) 362339(Creb3l2)
CGE: 
100762192(Creb3l1) 100766300(Creb3l4) 100771872(Creb3l2) 100772940(Creb3) 100774488(Creb3l3)
NGI: 
103726130(Creb3l2) 103737277(Creb3l3) 103741536(Creb3) 103748795(Creb3l1) 103751688(Creb3l4)
HGL: 
101698748(Creb3l1) 101706643(Creb3l4) 101715715(Creb3l2) 101716023(Creb3l3) 101718447(Creb3) 101720362
OCU: 
100343130(CREB3L2) 100345475(CREB3L1) 100357876(CREB3) 100358175(CREB3L4)
TUP: 
102468245 102469074(CREB3) 102471928(CREB3L2) 102484102(CREB3L3) 102491362(CREB3L1) 102494703(CREB3L4)
CFA: 
483636(CREB3L1) 485046(CREB3L3) 491369(CREB3L2) 611934(CREB3) 612303(CREB3L4)
AML: 
UMR: 
103667087(CREB3) 103668409(CREB3L4) 103669052(CREB3L2) 103672393(CREB3L1) 103681679(CREB3L3)
FCA: 
101087097(CREB3L1) 101089838(CREB3L3) 101093555(CREB3) 101100293(CREB3L2) 101100442(CREB3L4)
PTG: 
102949496(CREB3L2) 102949885(CREB3L1) 102950730(CREB3) 102954009(CREB3L4) 102956516(CREB3L3)
BTA: 
281715(CREB3) 513010(CREB3L3) 513105(CREB3L1) 529566(CREB3L4) 785086(CREB3L2)
BOM: 
102264680(CREB3L2) 102268154(CREB3L1) 102271999(CREB3L3) 102277321(CREB3) 102281505(CREB3L4)
PHD: 
102318329(CREB3) 102322586(CREB3L2) 102323426(CREB3L1) 102326449(CREB3L3) 102332306(CREB3L4)
CHX: 
102170199(CREB3L2) 102174829(CREB3L3) 102180221(CREB3) 102183745(CREB3L4) 102183893(CREB3L1)
OAS: 
101107485(CREB3L4) 101108743(CREB3L2) 101113586(CREB3L3) 101113882(CREB3L1) 101114243(CREB3)
SSC: 
100142688(CREB3L4) 100142689(CREB3) 100516663(CREB3L1) 100520468(CREB3L2) 100522979(CREB3L3)
CFR: 
102510171(CREB3L2) 102510394(CREB3) 102511454(CREB3L3) 102516586(CREB3L4) 102516625(CREB3L1)
BACU: 
102999898(CREB3L2) 103001736(CREB3) 103003868(CREB3L4) 103007680(CREB3L1) 103018056(CREB3L3)
LVE: 
103071696(CREB3L2) 103085711(CREB3L4) 103086171(CREB3) 103087008(CREB3L1) 103091030(CREB3L3)
ECB: 
100057002(CREB3L1) 100062307(CREB3L4) 100063153(CREB3L3) 100064828(CREB3L2) 100067794(CREB3)
MYB: 
102241829(CREB3) 102244833(CREB3L1) 102245296(CREB3L2) 102251355(CREB3L3) 102258024(CREB3L4)
MYD: 
102762431(CREB3) 102764297(CREB3L3) 102768092(CREB3L1) 102772259(CREB3L4) 102773515(CREB3L2)
PALE: 
102878515(CREB3L4) 102879289(CREB3L3) 102882888(CREB3L2) 102886510(CREB3) 102894633(CREB3L1)
MDO: 
100015046(CREB3L1) 100017208(CREB3L2) 100020067(CREB3L4) 100022547(CREB3L3) 103104366(CREB3)
SHR: 
100913890(CREB3L1) 100916355(CREB3) 100917654(CREB3L3) 100923082(CREB3L4) 100926416(CREB3L2)
OAA: 
GGA: 
100859610 418123(CREB3L2) 427417(CREB3) 428333(CREB3L3)
MGP: 
APLA: 
101792907(CREB3L2) 101793586(CREB3L3) 101795642(CREB3L1) 101798346
TGU: 
100219636(CREB3L2) 100220102(CREB3L1) 100222350(CREB3)
FAB: 
101807577(CREB3L1) 101807611 101810924(CREB3L2) 101814634(CREB3L3)
PHI: 
102100666(CREB3L1) 102102105(CREB3L3) 102104228(CREB3L2) 102110548(CREB3L4) 102110913(CREB3)
FPG: 
101915392(CREB3L1) 101915893(CREB3) 101922621(CREB3L2) 101924469(CREB3L3)
FCH: 
102049519(CREB3L3) 102052762(CREB3) 102055433(CREB3L2) 102060195(CREB3L1)
CLV: 
102083943(CREB3L2) 102089621(CREB3L1) 102093765(CREB3L3) 102095967(CREB3)
ASN: 
102371679(CREB3L2) 102375258(CREB3L3) 102378465(CREB3L1) 102380509(CREB3L4) 102387494
AMJ: 
102558288(CREB3L1) 102562994(CREB3L3) 102571170(CREB3L4) 102574172(CREB3L2)
PSS: 
102446107(CREB3L1) 102446716(CREB3L2) 102457323(CREB3L3)
CMY: 
102939907(CREB3L2) 102940413(CREB3L1) 102941831(CREB3L3) 102946430(CREB3L4) 102948242(CREB3)
ACS: 
100557424(creb3l2) 100565677(creb3l1) 103281351(creb3)
PBI: 
XLA: 
100037168(creb3l2) 735076(creb3-b)
XTR: 
100127204(creb3) 100145418(creb3l2) 100496679(creb3l1) 101733496 780164(creb3l4)
DRE: 
100333318(creb3l4) 338317(creb3l1) 406853(creb3l3l) 553700(creb3l3a) 791169(creb3l2)
TRU: 
MZE: 
OLA: 
XMA: 
LCM: 
102350106(CREB3L3) 102352986(CREB3L4) 102353080(CREB3L2) 102357132(CREB3L1) 102361726
CMK: 
103180995(creb3) 103181867(creb3l2) 103183529(creb3l3) 103186023(creb3l1)
BFO: 
CIN: 
778569(creb/atf-a) 778570(creb/atf-b)
SPU: 
AGA: 
AAG: 
AME: 
TCA: 
BMOR: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
ACAN: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lonze BE, Ginty DD
  Title
Function and regulation of CREB family transcription factors in the nervous system.
  Journal
Neuron 35:605-23 (2002)
Reference
  Authors
Mayr B, Montminy M
  Title
Transcriptional regulation by the phosphorylation-dependent factor CREB.
  Journal
Nat Rev Mol Cell Biol 2:599-609 (2001)

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