KEGG   ORTHOLOGY: K09048Help
Entry
K09048                      KO                                     

Name
CREB3
Definition
cyclic AMP-responsive element-binding protein 3
Pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Longevity regulating pathway
Adrenergic signaling in cardiomyocytes
TNF signaling pathway
Cholinergic synapse
Dopaminergic synapse
Insulin secretion
Estrogen signaling pathway
Melanogenesis
Thyroid hormone synthesis
Glucagon signaling pathway
Aldosterone synthesis and secretion
Insulin resistance
Vasopressin-regulated water reabsorption
Huntington's disease
Cocaine addiction
Amphetamine addiction
Alcoholism
Hepatitis B
Viral carcinogenesis
Prostate cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04668 TNF signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04024 cAMP signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04022 cGMP - PKG signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04151 PI3K-Akt signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04152 AMPK signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 Organismal Systems
  Endocrine system
   04911 Insulin secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04922 Glucagon signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04915 Estrogen signaling pathway
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04918 Thyroid hormone synthesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04916 Melanogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04925 Aldosterone synthesis and secretion
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Excretory system
   04962 Vasopressin-regulated water reabsorption
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Nervous system
   04725 Cholinergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   04728 Dopaminergic synapse
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Aging
   04211 Longevity regulating pathway - mammal
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05215 Prostate cancer
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Neurodegenerative diseases
   05016 Huntington's disease
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Substance dependence
   05030 Cocaine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05031 Amphetamine addiction
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
   05034 Alcoholism
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Endocrine and metabolic diseases
   04931 Insulin resistance
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
  Infectious diseases
   05161 Hepatitis B
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Basic leucine zipper (bZIP)
   CREB
    K09048  CREB3; cyclic AMP-responsive element-binding protein 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
10488(CREB3) 148327(CREB3L4) 64764(CREB3L2) 84699(CREB3L3) 90993(CREB3L1)
PTR: 
451704(CREB3L1) 457341(CREB3L4) 465081(CREB3) 468672(CREB3L3) 738928(CREB3L2)
PPS: 
100977358(CREB3L3) 100977804(CREB3L4) 100981063(CREB3L1) 100986194(CREB3L2) 100989680(CREB3)
GGO: 
101127253(CREB3L3) 101128609(CREB3L2) 101133101 101144135(CREB3) 101144628(CREB3L1) 101152081(CREB3L4)
PON: 
100127093(CREB3L2) 100432292(CREB3L1) 100436186(CREB3L4) 100438869(CREB3) 100441756(CREB3L3)
NLE: 
100592170(CREB3L3) 100594080(CREB3L1) 100595943(CREB3L2) 100597876(CREB3) 100603387(CREB3L4)
MCC: 
696350(CREB3) 713391(CREB3L1) 714981(CREB3L2) 715951(CREB3L4) 721825
MCF: 
102134095(CREB3L4) 102136437(CREB3L3) 102139679(CREB3) 102142378(CREB3L1) 102146405(CREB3L2) 107130150
RRO: 
104656623(CREB3L2) 104663511(CREB3L4) 104665486(CREB3L3) 104668385(CREB3L1) 104672444(CREB3)
CJC: 
100394351(CREB3L3) 100406635(CREB3L1) 100408954(CREB3) 100409637(CREB3L2) 100411140(CREB3L4)
MMU: 
12913(Creb3) 208647(Creb3l2) 208677(Creb3l3) 26427(Creb3l1) 78284(Creb3l4)
RNO: 
310616(Creb3l4) 314638(Creb3l3) 362165(Creb3l1) 362339(Creb3l2)
CGE: 
100762192(Creb3l1) 100766300(Creb3l4) 100771872(Creb3l2) 100772940(Creb3) 100774488(Creb3l3)
NGI: 
103726130(Creb3l2) 103737277(Creb3l3) 103741536(Creb3) 103748795(Creb3l1) 103751688(Creb3l4)
HGL: 
101698748(Creb3l1) 101706643(Creb3l4) 101715715(Creb3l2) 101716023(Creb3l3) 101718447(Creb3)
OCU: 
100343130(CREB3L2) 100345475(CREB3L1) 100357876(CREB3) 100358175(CREB3L4)
TUP: 
102468245 102469074(CREB3) 102471928(CREB3L2) 102484102(CREB3L3) 102491362(CREB3L1) 102494703(CREB3L4)
CFA: 
483636(CREB3L1) 485046(CREB3L3) 491369(CREB3L2) 611934(CREB3) 612303(CREB3L4)
AML: 
100465448(CREB3L3) 100470867(CREB3L1) 100472104(CREB3) 100483482(CREB3L2) 100484531(CREB3L4)
UMR: 
103667087(CREB3) 103668409(CREB3L4) 103669052(CREB3L2) 103672393(CREB3L1) 103681679(CREB3L3)
FCA: 
101087097(CREB3L1) 101089838(CREB3L3) 101093555(CREB3) 101100293(CREB3L2) 101100442(CREB3L4)
PTG: 
102949496(CREB3L2) 102949885(CREB3L1) 102950730(CREB3) 102954009(CREB3L4) 102956516(CREB3L3)
BTA: 
281715(CREB3) 513010(CREB3L3) 513105(CREB3L1) 529566(CREB3L4) 785086(CREB3L2)
BOM: 
102264680(CREB3L2) 102268154(CREB3L1) 102271999(CREB3L3) 102277321(CREB3) 102281505(CREB3L4)
PHD: 
102318329(CREB3) 102322586(CREB3L2) 102323426(CREB3L1) 102326449(CREB3L3) 102332306(CREB3L4)
CHX: 
102170199(CREB3L2) 102174829(CREB3L3) 102180221(CREB3) 102183745(CREB3L4) 102183893(CREB3L1)
OAS: 
101107485(CREB3L4) 101108743(CREB3L2) 101113586(CREB3L3) 101113882(CREB3L1) 101114243(CREB3)
SSC: 
100142688(CREB3L4) 100142689(CREB3) 100516663(CREB3L1) 100520468(CREB3L2) 100522979(CREB3L3)
CFR: 
102510171(CREB3L2) 102510394(CREB3) 102511454(CREB3L3) 102516586(CREB3L4) 102516625(CREB3L1)
BACU: 
102999898(CREB3L2) 103001736(CREB3) 103003868(CREB3L4) 103007680(CREB3L1) 103018056(CREB3L3)
LVE: 
103071696(CREB3L2) 103085711(CREB3L4) 103086171(CREB3) 103087008(CREB3L1) 103091030(CREB3L3)
ECB: 
100057002(CREB3L1) 100062307(CREB3L4) 100063153(CREB3L3) 100064828(CREB3L2) 100067794(CREB3)
MYB: 
102241829(CREB3) 102244833(CREB3L1) 102245296(CREB3L2) 102251355(CREB3L3) 102258024(CREB3L4)
MYD: 
102762431(CREB3) 102764297(CREB3L3) 102768092(CREB3L1) 102772259(CREB3L4) 102773515(CREB3L2)
PALE: 
102878515(CREB3L4) 102879289(CREB3L3) 102882888(CREB3L2) 102886510(CREB3) 102894633(CREB3L1)
MDO: 
100015046(CREB3L1) 100017208(CREB3L2) 100020067(CREB3L4) 100022547(CREB3L3) 103104366(CREB3)
SHR: 
100913890(CREB3L1) 100916355(CREB3) 100917654(CREB3L3) 100923082(CREB3L4) 100926416(CREB3L2)
OAA: 
100076562(CREB3L1) 100078176(CREB3L3) 100092528(CREB3L2) 103165821(CREB3)
GGA: 
100859610(CREB3L1) 418123(CREB3L2) 427417(CREB3) 428333(CREB3L3)
MGP: 
100539552(CREB3L1) 100551035(CREB3L2) 100551184(CREB3L3) 104914805(CREB3)
APLA: 
101792907(CREB3L2) 101793586(CREB3L3) 101795642(CREB3L1) 101798346
TGU: 
100219636(CREB3L2) 100220102(CREB3L1) 100222350(CREB3)
GFR: 
102032931(CREB3L1) 102037565(CREB3L2) 102040985(CREB3L3) 102041988(CREB3)
FAB: 
101807577(CREB3L1) 101807611(CREB3) 101810924(CREB3L2) 101814634(CREB3L3)
PHI: 
102100666(CREB3L1) 102102105(CREB3L3) 102104228(CREB3L2) 102110548(CREB3L4) 102110913(CREB3)
CCW: 
104686582(CREB3) 104696487(CREB3L2) 104697409(CREB3L3) 104698184(CREB3L1)
FPG: 
101915392(CREB3L1) 101915893(CREB3) 101922621(CREB3L2) 101924469(CREB3L3)
FCH: 
102049519(CREB3L3) 102052762(CREB3) 102055433(CREB3L2) 102060195(CREB3L1) 106630837(CREB3L4)
CLV: 
102083943(CREB3L2) 102089621(CREB3L1) 102093765(CREB3L3) 102095967(CREB3)
ASN: 
102371679(CREB3L2) 102375258(CREB3L3) 102378465(CREB3L1) 102380509(CREB3L4) 102387494(CREB3)
AMJ: 
102558288(CREB3L1) 102562994(CREB3L3) 102565945(CREB3) 102571170(CREB3L4) 102574172(CREB3L2)
PSS: 
102446107(CREB3L1) 102446716(CREB3L2) 102457323(CREB3L3)
CMY: 
102939907(CREB3L2) 102940413(CREB3L1) 102941831(CREB3L3) 102946430(CREB3L4) 102948242(CREB3)
ACS: 
100557424(creb3l2) 100565677(creb3l1) 103281351(creb3)
PBI: 
XLA: 
100037168(creb3l2) 735076(creb3-b)
XTR: 
100127204(creb3) 100145418(creb3l2) 100496679(creb3l1) 101733496(creb3l3) 780164(creb3l4)
DRE: 
100333318(creb3l4) 338317(creb3l1) 406853(creb3l3l) 553700(creb3l3a) 791169(creb3l2)
TRU: 
101063133(creb3l4) 101065014(creb3l3) 101067583 101070432(creb3l1) 101078259(creb3l2)
MZE: 
101466226(creb3l4) 101469085(creb3l1) 101480575(creb3l2) 101483965(creb3l3) 101486384 101487513
OLA: 
XMA: 
LCM: 
102350106(CREB3L3) 102352986(CREB3L4) 102353080(CREB3L2) 102357132(CREB3L1) 102361726
CMK: 
103180995(creb3) 103181867(creb3l2) 103183529(creb3l3) 103186023(creb3l1)
BFO: 
CIN: 
778569(creb/atf-a) 778570(creb/atf-b)
SPU: 
SKO: 
DWI: 
AGA: 
AAG: 
CQU: 
AME: 
SOC: 
AEC: 
HST: 
CFO: 
TCA: 
BMOR: 
PXY: 
API: 
PHU: 
ISC: 
BMY: 
LOA: 
TSP: 
HRO: 
LGI: 
CRG: 
OBI: 
SMM: 
NVE: 
HMG: 
TAD: 
AQU: 
SRE: 
ACAN: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lonze BE, Ginty DD
  Title
Function and regulation of CREB family transcription factors in the nervous system.
  Journal
Neuron 35:605-23 (2002)
Reference
  Authors
Mayr B, Montminy M
  Title
Transcriptional regulation by the phosphorylation-dependent factor CREB.
  Journal
Nat Rev Mol Cell Biol 2:599-609 (2001)
Reference
  Authors
Jang SW, Kim YS, Kim YR, Sung HJ, Ko J
  Title
Regulation of human LZIP expression by NF-kappaB and its involvement in monocyte  cell migration induced by Lkn-1.
  Journal
J Biol Chem 282:11092-100 (2007)
  Sequence
[hsa:10488]

DBGET integrated database retrieval system