KEGG ORTHOLOGY: K09451

ORTHOLOGY: K09451

Entry

K09451                      KO

Symbol

ALX4

Name

homeobox protein aristaless-like 4

Disease

H00475

Enlarged parietal foramina/cranium bifidum

H00528

Frontonasal dysplasia

H02160

Craniosynostoses

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09451  ALX4; homeobox protein aristaless-like 4
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Homeo domain Paired-related
    K09451  ALX4; homeobox protein aristaless-like 4

Genes

HSA:	60529(ALX4)

PTR:	466496(ALX4)

PPS:	100992931(ALX4)

GGO:	101131165(ALX4)

PON:	100435790(ALX4)

NLE:	100603231(ALX4)

HMH:	116476324(ALX4)

MCC:	715652(ALX4)

MCF:	102135462(ALX4)

MTHB:

126936271

MNI:	105471615(ALX4)

CSAB:

103237034(ALX4)

CATY:

105586841(ALX4)

PANU:

101017788(ALX4)

TGE:	112606828(ALX4)

MLEU:

105554778(ALX4)

RRO:	104673883(ALX4)

RBB:	108519257(ALX4)

TFN:	117081395(ALX4)

PTEH:

111544933(ALX4)

CANG:

105527087(ALX4)

CJC:	100412287(ALX4)

SBQ:	101039733(ALX4)

CIMI:

108304906(ALX4)

MMUR:

105885488(ALX4)

LCAT:

123642623(ALX4)

PCOQ:

105819144(ALX4)

OGA:	100950241(ALX4)

MMU:	11695(Alx4)

MCAL:

110290493(Alx4)

MPAH:

110318567(Alx4)

RNO:	296511(Alx4)

MCOC:

116090517(Alx4)

ANU:	117704510(Alx4)

MUN:	110554143(Alx4)

CGE:	100750505(Alx4)

MAUA:

101833638(Alx4)

PROB:

127222214(Alx4)

PLEU:

114699728(Alx4)

MORG:

121440564(Alx4)

MFOT:

126504518

AAMP:

119815453(Alx4)

NGI:	103751551(Alx4)

HGL:	101715465(Alx4)

CPOC:

100715494(Alx4)

CCAN:

109686417(Alx4)

DORD:

105996047(Alx4)

DSP:	122100747(Alx4)

PLOP:

125362322(Alx4)

NCAR:

124960330

MMMA:

107134541(Alx4)

OCU:

100347124

OPI:	101535841(ALX4)

TUP:	102489685(ALX4)

GVR:	103596581(ALX4)

CFA:	609979(ALX4)

CLUD:

112663259(ALX4)

VVP:	112924117(ALX4)

VLG:	121471825(ALX4)

NPO:	129503162(ALX4)

AML:	100476015(ALX4)

UMR:	103672402(ALX4)

UAH:	113264885(ALX4)

UAR:	123799569(ALX4)

ELK:

111150196

LLV:

125079083

MPUF:

101672646(ALX4)

MNP:	132008239 132008416

MLK:	131839549(ALX4)

NVS:	122914312(ALX4)

ORO:	101366197(ALX4)

EJU:	114215154(ALX4)

ZCA:	113915233(ALX4)

MLX:	118015786(ALX4)

NSU:	110575742(ALX4)

LWW:	102727981 102745214(ALX4)

FCA:	101083878(ALX4)

PYU:	121043514(ALX4)

PCOO:

112865944(ALX4)

PBG:	122483729(ALX4)

PVIV:

125146760(ALX4)

LRUF:

124504568

PTG:	102950465(ALX4)

PPAD:

109279212(ALX4)

PUC:

125912821

AJU:

113603390

HHV:	120228494(ALX4)

BTA:	594846(ALX4)

BOM:	102278186(ALX4)

BBUB:

102416377(ALX4)

BBIS:

104982779(ALX4)

CHX:	102182521(ALX4)

OAS:	101116426(ALX4)

BTAX:

128060961(ALX4)

ODA:	120876913(ALX4)

CCAD:

122450218(ALX4)

MBEZ:

129554775(ALX4)

SSC:	100738855(ALX4)

CFR:	102514391(ALX4)

CBAI:

105076486(ALX4)

CDK:	105106839(ALX4)

VPC:	102542156(ALX4)

BACU:

103000008(ALX4)

BMUS:

118899924(ALX4)

LVE:	103090750(ALX4)

OOR:	101281206(ALX4)

DLE:	111184116(ALX4)

PCAD:

102979583(ALX4)

PSIU:

116758467(ALX4)

NASI:

112402487(ALX4)

ECB:	100055958(ALX4)

EPZ:	103556460(ALX4)

EAI:	106843972(ALX4)

MYB:	102243643(ALX4)

MMYO:

118664010(ALX4)

MLF:	102421695(ALX4)

PKL:	118713558(ALX4)

EFUS:

103290861(ALX4)

MNA:	107525501(ALX4)

DRO:	112303384(ALX4)

SHON:

119002974(ALX4)

AJM:	119064471(ALX4)

PDIC:

114499671(ALX4)

PHAS:

123809944(ALX4)

MMF:	118629032(ALX4)

PPAM:

129081522(ALX4)

HAI:	109391958(ALX4)

RFQ:	117029881(ALX4)

PALE:

102890868(ALX4)

PGIG:

120606332(ALX4)

PVP:	105289996(ALX4)

RAY:	107511885(ALX4)

MJV:	108394754(ALX4)

TOD:	119255340(ALX4)

SARA:

101551606(ALX4)

SETR:

126017670(ALX4)

LAV:	100655737(ALX4)

TMU:

101340403

ETF:	101662777(ALX4)

DNM:	101436509(ALX4)

MDO:	100013656(ALX4)

GAS:	123251990(ALX4)

SHR:	100928580(ALX4)

AFZ:

127541099

PCW:	110224052(ALX4)

OAA:	114810230(ALX4)

GGA:	373976(ALX4)

PCOC:

116229132(ALX4)

MGP:	104911117(ALX4)

CJO:	107314817(ALX4)

TPAI:

128085845(ALX4)

LMUT:

125695243(ALX4)

NMEL:

110401312(ALX4)

APLA:

101791005(ALX4)

ACYG:

106040838(ALX4)

CATA:

118250845(ALX4)

AFUL:

116490351(ALX4)

TGU:	100221903(ALX4)

LSR:	110472168(ALX4)

SCAN:

103826715(ALX4)

PMOA:

120512576(ALX4)

OTC:	121332461(ALX4)

PRUF:

121349513(ALX4)

GFR:	102039344(ALX4)

FAB:	101814472(ALX4)

OMA:	130254398(ALX4)

PHI:	102107660(ALX4)

PMAJ:

107205294(ALX4)

CCAE:

111930144(ALX4)

CCW:	104688112(ALX4)

CBRC:

103620915(ALX4)

ETL:	114064865(ALX4)

ZAB:	102061985(ALX4)

SVG:	106851512(ALX4)

MMEA:

130572525(ALX4)

HRT:	120754753(ALX4)

FPG:	101923717(ALX4)

FCH:	102056129(ALX4)

CLV:	102087926(ALX4)

EGZ:	104134100(ALX4)

NNI:	104019572(ALX4)

ACUN:

113480528(ALX4)

TALA:

116965820(ALX4)

PADL:

103921726(ALX4)

AFOR:

103897534(ALX4)

ACHC:

115338366(ALX4)

HLE:	104839719(ALX4)

AGEN:

126049455

GCL:

127017428

CCRI:

104166422(ALX4)

CMAC:

104485479(ALX4)

MUI:	104536561 104539785(ALX4)

BREG:

104632667(ALX4)

OHA:	104330182(ALX4)

SHAB:

115606759(ALX4)

DPUB:

104297452(ALX4)

CPEA:

104390388(ALX4)

AVIT:

104279769

RTD:	128908885(ALX4)

CUCA:

104067269(ALX4)

AAM:	106498201(ALX4)

AROW:

112978376(ALX4)

NPD:	112943839(ALX4)

TGT:	104565026(ALX4)

DNE:	112979251(ALX4)

SCAM:

104149275(ALX4)

ASN:	102378791(ALX4)

AMJ:	102561960(ALX4)

CPOO:

109321362(ALX4)

GGN:	109298934(ALX4)

PSS:	102447003(ALX4)

CMY:	102938694(ALX4)

CCAY:

125638922(ALX4)

DCC:	119857682(ALX4)

CPIC:

101949009(ALX4)

TST:	117876972(ALX4)

CABI:

116830768(ALX4)

MRV:	120405431(ALX4)

ACS:	100558644(alx4)

ASAO:

132768468(ALX4)

PVT:	110082461(ALX4)

SUND:

121926615(ALX4)

PBI:	103053646(ALX4)

PMUR:

107302596(ALX4)

CTIG:

120307971(ALX4)

TSR:	106545005(ALX4)

PGUT:

117665493(ALX4)

APRI:

131187437(ALX4)

PTEX:

113439025(ALX4)

NSS:	113410219(ALX4)

VKO:	123026971(ALX4)

PMUA:

114596265(ALX4)

PRAF:

128413510(ALX4)

ZVI:	118085374(ALX4)

HCG:	128340050(ALX4)

GJA:	107122613(ALX4)

STOW:

125427189(ALX4)

EMC:	129325012(ALX4)

XLA:	108713752 108715264

XTR:	100493396(alx4)

NPR:	108786032(ALX4)

RTEM:

120917050(ALX4)

BBUF:

120981040(ALX4)

BGAR:

122920746(ALX4)

MUO:	115467971(ALX4)

GSH:

117352341

DRE:	100006399(alx4a)

SRX:	107746571 107750553 107752273 107754690

SANH:

107656842 107657598 107683603 107688160

SGH:	107554474 107554564 107578512 107585936(alx4) 107593440

CCAR:

109072429 109074536 109083257 109113528

CAUA:

113052038 113061653 113105759(alx4) 113118480

CGIB:

127933870 127962008 127977209 128017047

PTET:

122349072(alx4a) 122362638(alx4b)

LROH:

127168415(alx4a) 127180769(alx4b)

OMC:	131544221(alx4a)

PPRM:

120468016(alx4a) 120487609(alx4b)

RKG:	130089009(alx4b) 130102645(alx4a)

MAMB:

125254817(alx4b) 125264630(alx4a)

CIDE:

127500252 127516480

MASI:

127416825 127442780 127454849 127456083

TROS:

130556178(alx4a) 130562603(alx4b)

TDW:	130424339(alx4a) 130435562(alx4b)

MANU:

129419702 129441628(alx4a)

IPU:	108271351(alx4a)

IFU:	128613390(alx4a)

PHYP:

113536426(alx4)

SMEO:

124390803(alx4a)

TFD:	113663260(alx4a)

TVC:	132842747(alx4a)

AMEX:

103046081(alx4)

CMAO:

118819459(alx4a)

EEE:	113575766(alx4)

CHAR:

105907221 105910397

TRU:	101066273 101079447

TFS:	130521448(alx4a) 130536666

TNG:	GSTEN00017826G001 GSTEN00029796G001

LCO:	104919191 104940611

NCC:	104942814 104963024

TBEN:

117491739

CGOB:

115010022(alx4) 115023959

PGEO:

117447668 117465624(alx4a)

GACU:

117538837 117547698(alx4a)

EMAC:

134863698(alx4a) 134875687

ELY:	117257721(alx4a) 117261729(alx4b)

EFO:	125881293(alx4a) 125887187(alx4b)

PLEP:

121950362 121952321(alx4a)

SLUC:

116034021(alx4a) 116038598

ECRA:

117943855(alx4a) 117949650(alx4b)

ESP:	116688737 116694266(alx4)

PFLV:

114559756 114560475

GAT:	120808563(alx4a) 120809770

PPUG:

119196730(alx4b) 119229343(alx4a)

AFB:

129108792

CLUM:

117732535

PSWI:

130192469(alx4a) 130195178

MSAM:

119890107(alx4a) 119893579

SCHU:

122874716 122875961(alx4a)

CUD:	121512810(alx4a) 121514611

ALAT:

119018314(alx4a) 119023700(alx4b)

MZE:	101473292 101483540(alx4)

ONL:	100695379 100697940

OAU:	116327173(alx4a) 116332633(alx4b)

OLA:	101165626 101168948

OML:	112151723(alx4b) 112160397(alx4a)

CSAI:

133443758(alx4b) 133461588(alx4a)

XMA:	102217741(alx4) 102234190

XCO:	114135217 114142778 114161473

XHE:	116711197(alx4) 116718350

PRET:

103462433 103466406 103481191

PFOR:

103139432(alx4) 103150256

PLAI:

106957623 106958191(alx4)

PMEI:

106915854 106926107(alx4)

GAF:	122821856(alx4a) 122836224

PPRL:

129357920 129366496 129369399

CVG:	107085588(alx4) 107097956 107102389

CTUL:

119776134 119782771(alx4a)

GMU:	124866744(alx4a) 124878515

NFU:	107381444 107388616 107389359

KMR:	108228682(alx4a) 108229875(alx4b)

ALIM:

106526847 106530774(alx4)

AOCE:

111567811 111573648 111574617

MCEP:

125005112(alx4a) 125015506(alx4b)

CSEM:

103378750 103380441(alx4)

POV:	109623595(alx4) 109636798

SSEN:

122772601(alx4a) 122775438(alx4b)

HHIP:

117758304(alx4a) 117762887(alx4b)

HSP:	118109011 118109148(alx4a)

SMAU:

118302886(alx4a) 118314817(alx4b)

LCF:	108876707 108889672

SDU:	111229909 111238425

SLAL:

111654813 111661639(alx4)

XGL:	120793731(alx4b) 120794416(alx4a)

HCQ:	109507645(alx4) 109514467

SSCV:

125967050 125970713

SBIA:

133502103

PEE:	133399177 133402459(alx4b)

PTAO:

133470782 133478594(alx4b)

BPEC:

110169757(alx4) 110173101

MALB:

109963234 109974256

BSPL:

114852236(alx4a) 114857660(alx4b)

SJO:	128357981(alx4a) 128358969

SASA:

106561713 106562319 106573273 106587508

STRU:

115167098 115181518 115203229

OTW:	112239997 112247035(alx4a) 112264223

OMY:	110500713 110506670 110526538

OGO:	124032118 124033639 124035623

ONE:	115112436 115113719 115125622

OKI:	109873167 109881442 109887114

OKE:	118360339 118382694 118393987

SALP:

111952293 111969485(alx4) 112072769

SNH:	120024957 120056877

CCLU:

121568052 121577385 123484465 123484713

ELS:	105018322 105022261

SFM:	108934704 108940457

PKI:	111840713(alx4) 111859449

AANG:

118215431(alx4b) 118227908

LOC:	102689233(alx4)

PSPA:

121294885 121329637

ARUT:

117432033 117434862

PSEX:

120517026(alx4a)

LCM:	102363799(ALX4)

CMK:	103174977(alx4a)

RTP:	109910903(alx4a)

CPLA:

122557656(alx4a)

LERI:

129705554(alx4a)

PMRN:

116939871(ALX1)

LRJ:	133350349 133351435

BFO:	118414178 118414179

BBEL:

109469555 109481696 109481699

SPU:	373521(Alx1) 580069

APLC:

110977982 110978045

AJC:

117112420

SKO:	100329074 100372398

FEX:

SOY:

AGB:

OTU:

MSEX:

BANY:

PPOT:

PXU:

PRAP:

SLIU:

OFU:

PVUL:

PCAN:

BGT:

GAE:

HRJ:	124266198 124273171

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

LAK:	106151260 106175874

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:	124454170 124454444

TAD:	TRIADDRAFT_57021

» show all

Reference

PMID:19692347

Authors

Kayserili H, Uz E, Niessen C, Vargel I, Alanay Y, Tuncbilek G, Yigit G, Uyguner O, Candan S, Okur H, Kaygin S, Balci S, Mavili E, Alikasifoglu M, Haase I, Wollnik B, Akarsu NA

Title

ALX4 dysfunction disrupts craniofacial and epidermal development.

Journal

Hum Mol Genet 18:4357-66 (2009)
DOI:10.1093/hmg/ddp391

Sequence

[hsa:60529]

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   KEGG BRITE (2)   
Disease (3)   
   KEGG DISEASE (3)   
Gene (682)   
   KEGG GENES (548)   
   KEGG MGENES (70)   
   RefGene (59)   
   OC (5)   
Literature (1)   
   PubMed (1)   
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