KEGG   ORTHOLOGY: K10054Help
Entry
K10054                      KO                                     
Name
PML, TRIM19
Definition
probable transcription factor PML
Pathway
Ubiquitin mediated proteolysis
Endocytosis
Influenza A
Herpes simplex infection
Pathways in cancer
Transcriptional misregulation in cancer
Acute myeloid leukemia
Disease
H00003  
Acute myeloid leukemia (AML)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10054  PML, TRIM19; probable transcription factor PML
 Cellular Processes
  Transport and catabolism
   04144 Endocytosis
    K10054  PML, TRIM19; probable transcription factor PML
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K10054  PML, TRIM19; probable transcription factor PML
   05202 Transcriptional misregulation in cancers
    K10054  PML, TRIM19; probable transcription factor PML
   05221 Acute myeloid leukemia
    K10054  PML, TRIM19; probable transcription factor PML
  Infectious diseases
   05164 Influenza A
    K10054  PML, TRIM19; probable transcription factor PML
   05168 Herpes simplex infection
    K10054  PML, TRIM19; probable transcription factor PML
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  single Ring-finger type E3
   TRIM/RBCC proteins
    K10054  PML, TRIM19; probable transcription factor PML
BRITE hierarchy
Genes
HSA: 
5371(PML)
PTR: 
453736(PML)
PPS: 
GGO: 
PON: 
MCC: 
700379(PML)
MMU: 
18854(Pml)
RNO: 
315713(Pml)
CFA: 
487641(PML)
AML: 
FCA: 
101086975(PML)
BTA: 
100138545(PML)
SSC: 
100157336(PML)
ECB: 
100062744(PML)
MDO: 
100029464
SHR: 
100925902
OAA: 
100076474
GGA: 
415302(PML) 415304(PML)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP
  Title
The function of PML in p53-dependent apoptosis.
  Journal
Nat Cell Biol 2:730-6 (2000)
Reference
  Authors
Lin HK, Bergmann S, Pandolfi PP
  Title
Cytoplasmic PML function in TGF-beta signalling.
  Journal
Nature 431:205-11 (2004)
Reference
  Authors
Dellaire G, Ching RW, Ahmed K, Jalali F, Tse KC, Bristow RG, Bazett-Jones DP
  Title
Promyelocytic leukemia nuclear bodies behave as DNA damage sensors whose response to DNA double-strand breaks is regulated by NBS1 and the kinases ATM, Chk2, and ATR.
  Journal
J Cell Biol 175:55-66 (2006)
Reference
  Authors
Cuchet D, Sykes A, Nicolas A, Orr A, Murray J, Sirma H, Heeren J, Bartelt A, Everett RD
  Title
PML isoforms I and II participate in PML-dependent restriction of HSV-1 replication.
  Journal
J Cell Sci 124:280-91 (2011)
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