KEGG   ORTHOLOGY: K10132Help
Entry
K10132                      KO                                     

Name
BBC3, PUMA
Definition
Bcl-2-binding component 3
Pathway
Platinum drug resistance
p53 signaling pathway
Apoptosis
Apoptosis - multiple species
Hippo signaling pathway
Huntington's disease
Measles
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04390 Hippo signaling pathway
    K10132  BBC3, PUMA; Bcl-2-binding component 3
 Cellular Processes
  Cell growth and death
   04210 Apoptosis
    K10132  BBC3, PUMA; Bcl-2-binding component 3
   04215 Apoptosis - multiple species
    K10132  BBC3, PUMA; Bcl-2-binding component 3
   04115 p53 signaling pathway
    K10132  BBC3, PUMA; Bcl-2-binding component 3
 Human Diseases
  Neurodegenerative diseases
   05016 Huntington's disease
    K10132  BBC3, PUMA; Bcl-2-binding component 3
  Infectious diseases
   05162 Measles
    K10132  BBC3, PUMA; Bcl-2-binding component 3
  Drug resistance
   01524 Platinum drug resistance
    K10132  BBC3, PUMA; Bcl-2-binding component 3
BRITE hierarchy
Genes
HSA: 
27113(BBC3)
PTR: 
107969772(BBC3) 746617(BBC3)
PPS: 
100974112(BBC3)
GGO: 
101125453(BBC3)
PON: 
NLE: 
100588342(BBC3)
MCC: 
717955(BBC3)
MCF: 
102119825(BBC3)
CSAB: 
103234932(BBC3)
RRO: 
104673391(BBC3)
CJC: 
100387604(BBC3)
SBQ: 
MMU: 
170770(Bbc3)
RNO: 
317673(Bbc3)
CGE: 
103164214(Bbc3)
NGI: 
103724866(Bbc3)
HGL: 
101714844(Bbc3)
OCU: 
100357703(BBC3)
TUP: 
102499950(BBC3)
CFA: 
612153(BBC3)
AML: 
100474559(BBC3)
UMR: 
103657211(BBC3)
FCA: 
102900443(BBC3)
PTG: 
102955464(BBC3)
BTA: 
782359(BBC3)
BOM: 
102284902(BBC3)
PHD: 
102343353(BBC3)
CHX: 
102171367(BBC3)
OAS: 
SSC: 
100517403(BBC3)
CFR: 
102512800(BBC3)
BACU: 
103003912(BBC3)
LVE: 
103087294(BBC3)
ECB: 
100146714(BBC3)
MYB: 
102253129(BBC3)
MYD: 
102753249(BBC3)
PALE: 
102892591(BBC3)
LAV: 
100671262(BBC3)
MDO: 
100020711(BBC3)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yu J, Zhang L, Hwang PM, Kinzler KW, Vogelstein B
  Title
PUMA induces the rapid apoptosis of colorectal cancer cells.
  Journal
Mol Cell 7:673-82 (2001)
  Sequence
[hsa:27113]
Reference
  Authors
Ren D, Tu HC, Kim H, Wang GX, Bean GR, Takeuchi O, Jeffers JR, Zambetti GP, Hsieh JJ, Cheng EH
  Title
BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
  Journal
Science 330:1390-3 (2010)
  Sequence
[mmu:170770]

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