Entry |
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Name |
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Definition |
DNA damage-binding protein 2
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Pathway |
| Nucleotide excision repair | | p53 signaling pathway | | Ubiquitin mediated proteolysis | | Hepatitis B | | Pathways in cancer | | Transcriptional misregulation in cancer | | Colorectal cancer | | Pancreatic cancer | | Endometrial cancer | | Glioma | | Thyroid cancer | | Basal cell carcinoma | | Melanoma | | Chronic myeloid leukemia | | Small cell lung cancer | | Non-small cell lung cancer | | Breast cancer | | Hepatocellular carcinoma | | Gastric cancer |
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Module |
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Disease |
| Disorders of nucleotide excision repair | | Xeroderma pigmentosum (XP) |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
Genetic Information Processing
Folding, sorting and degradation
04120 Ubiquitin mediated proteolysis
K10140 DDB2; DNA damage-binding protein 2
Replication and repair
03420 Nucleotide excision repair
K10140 DDB2; DNA damage-binding protein 2
Cellular Processes
Cell growth and death
04115 p53 signaling pathway
K10140 DDB2; DNA damage-binding protein 2
Human Diseases
Cancers
05200 Pathways in cancer
K10140 DDB2; DNA damage-binding protein 2
05202 Transcriptional misregulation in cancers
K10140 DDB2; DNA damage-binding protein 2
05210 Colorectal cancer
K10140 DDB2; DNA damage-binding protein 2
05212 Pancreatic cancer
K10140 DDB2; DNA damage-binding protein 2
05225 Hepatocellular carcinoma
K10140 DDB2; DNA damage-binding protein 2
05226 Gastric cancer
K10140 DDB2; DNA damage-binding protein 2
05214 Glioma
K10140 DDB2; DNA damage-binding protein 2
05216 Thyroid cancer
K10140 DDB2; DNA damage-binding protein 2
05220 Chronic myeloid leukemia
K10140 DDB2; DNA damage-binding protein 2
05217 Basal cell carcinoma
K10140 DDB2; DNA damage-binding protein 2
05218 Melanoma
K10140 DDB2; DNA damage-binding protein 2
05213 Endometrial cancer
K10140 DDB2; DNA damage-binding protein 2
05224 Breast cancer
K10140 DDB2; DNA damage-binding protein 2
05222 Small cell lung cancer
K10140 DDB2; DNA damage-binding protein 2
05223 Non-small cell lung cancer
K10140 DDB2; DNA damage-binding protein 2
Infectious diseases
05161 Hepatitis B
K10140 DDB2; DNA damage-binding protein 2
KEGG modules [BR:ko00002]
Structural complex
Genetic information processing
Ubiquitin system
M00385 Cul4-DDB1-DDB2 complex
K10140 DDB2; DNA damage-binding protein 2
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
Multi subunit Ring-finger type E3
Cul4 complex
Target recognizing subunit (DCAF)
K10140 DDB2; DNA damage-binding protein 2
DNA repair and recombination proteins [BR:ko03400]
Eukaryotic Type
SSBR (single strand breaks repair)
NER (nucleotide excision repair)
GGR (global genome repair) factors
Cul4-DDB2 complex
K10140 DDB2; DNA damage-binding protein 2
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Genes |
HSA: | | PTR: | | PPS: | | GGO: | | PON: | | NLE: | | MCC: | | MCF: | | CSAB: | | RRO: | | RBB: | | CJC: | | SBQ: | | MMU: | | RNO: | | CGE: | | NGI: | | HGL: | | CCAN: | | OCU: | | TUP: | | CFA: | | AML: | | UMR: | | ORO: | | FCA: | | PTG: | | AJU: | | BTA: | | BOM: | | BIU: | | PHD: | | CHX: | | OAS: | | SSC: | | CFR: | | CDK: | | BACU: | | LVE: | | OOR: | | ECB: | | EPZ: | | EAI: | | MYB: | | MYD: | | HAI: | | RSS: | | PALE: | | LAV: | | TMU: | | MDO: | | SHR: | | OAA: | | GGA: | | MGP: | | CJO: | | APLA: | | ACYG: | | TGU: | | GFR: | | FAB: | | PHI: | | PMAJ: | | CCW: | | FPG: | | FCH: | | CLV: | | EGZ: | | AAM: | | ASN: | | AMJ: | | PSS: | | CMY: | | CPIC: | | ACS: | | PVT: | | PBI: | | GJA: | | XLA: | | XTR: | | NPR: | | DRE: | | SRX: | | SANH: | | SGH: | | CCAR: | | AMEX: | | TRU: | | TNG: | | LCO: | | NCC: | | MZE: | | OLA: | | XMA: | | PRET: | | NFU: | | CSEM: | | LCF: | | HCQ: | | BPEC: | | SASA: | | ELS: | | SFM: | | BFO: | | SPU: | | APLC: | | SKO: | | PHU: | | FCD: | | DPX: | | ISC: | | TUT: | | LGI: | | CRG: | | MYI: | | LAK: | | AQU: | | ATH: | | ALY: | | CSAT: | | EUS: | | BRP: | | BNA: | | BOE: | | THJ: | | CPAP: | | CIT: | | CIC: | | TCC: | | GRA: | | GHI: | | DZI: | | EGR: | | GMX: | | PVU: | | VRA: | | VAR: | | CCAJ: | | MTR: | | CAM: | | ADU: | | AIP: | | LJA: | | LANG: | | FVE: | | PPER: | | PMUM: | | PAVI: | | MDM: | | PXB: | | ZJU: | | CSV: | | CMO: | | MCHA: | | CMAX: | | CMOS: | | RCU: | | JCU: | | HBR: | | JRE: | | VVI: | | SLY: | | SPEN: | | SOT: | | CANN: | | NTA: | | NSY: | | NTO: | | INI: | | SIND: | | OEU: | | HAN: | | BVG: | | SOE: | | NNU: | | OSA: | | DOSA: | | OBR: | | BDI: | | ATS: | | SBI: | | ZMA: | | SITA: | | PDA: | | EGU: | | MUS: | | DCT: | | AOF: | | ATR: | | SMO: | | VCN: | | CSL: | | CVR: | | APRO: | | GSL: | | CCP: | | » show all
   |
Reference |
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Authors |
Kulaksiz G, Reardon JT, Sancar A |
Title |
Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties. |
Journal |
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Sequence |
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Reference |
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Authors |
Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapic-Otrin V, Levine AS |
Title |
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites. |
Journal |
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Sequence |
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Reference |
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Authors |
Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S |
Title |
Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein. |
Journal |
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Sequence |
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