KEGG   ORTHOLOGY: K10140Help
Entry
K10140                      KO                                     

Name
DDB2
Definition
DNA damage-binding protein 2
Pathway
Nucleotide excision repair
p53 signaling pathway
Ubiquitin mediated proteolysis
Hepatitis B
Transcriptional misregulation in cancer
Colorectal cancer
Pancreatic cancer
Endometrial cancer
Glioma
Thyroid cancer
Basal cell carcinoma
Melanoma
Chronic myeloid leukemia
Small cell lung cancer
Non-small cell lung cancer
Breast cancer
Hepatocellular carcinoma
Module
M00385  
Cul4-DDB1-DDB2 complex
Disease
H00403  
Disorders of nucleotide excision repair
H01428  
Xeroderma pigmentosum (XP)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10140  DDB2; DNA damage-binding protein 2
  Replication and repair
   03420 Nucleotide excision repair
    K10140  DDB2; DNA damage-binding protein 2
 Cellular Processes
  Cell growth and death
   04115 p53 signaling pathway
    K10140  DDB2; DNA damage-binding protein 2
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K10140  DDB2; DNA damage-binding protein 2
   05210 Colorectal cancer
    K10140  DDB2; DNA damage-binding protein 2
   05212 Pancreatic cancer
    K10140  DDB2; DNA damage-binding protein 2
   05225 Hepatocellular carcinoma
    K10140  DDB2; DNA damage-binding protein 2
   05214 Glioma
    K10140  DDB2; DNA damage-binding protein 2
   05216 Thyroid cancer
    K10140  DDB2; DNA damage-binding protein 2
   05220 Chronic myeloid leukemia
    K10140  DDB2; DNA damage-binding protein 2
   05217 Basal cell carcinoma
    K10140  DDB2; DNA damage-binding protein 2
   05218 Melanoma
    K10140  DDB2; DNA damage-binding protein 2
   05213 Endometrial cancer
    K10140  DDB2; DNA damage-binding protein 2
   05224 Breast cancer
    K10140  DDB2; DNA damage-binding protein 2
   05222 Small cell lung cancer
    K10140  DDB2; DNA damage-binding protein 2
   05223 Non-small cell lung cancer
    K10140  DDB2; DNA damage-binding protein 2
  Infectious diseases
   05161 Hepatitis B
    K10140  DDB2; DNA damage-binding protein 2
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00385  Cul4-DDB1-DDB2 complex
     K10140  DDB2; DNA damage-binding protein 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul4 complex
    Target recognizing subunit (DCAF)
     K10140  DDB2; DNA damage-binding protein 2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K10140  DDB2; DNA damage-binding protein 2
BRITE hierarchy
Genes
HSA: 
1643(DDB2)
PTR: 
451165(DDB2)
PPS: 
100972583(DDB2)
GGO: 
101128036(DDB2)
PON: 
100454099(DDB2)
NLE: 
100605065(DDB2)
MCC: 
713813(DDB2)
MCF: 
102124623(DDB2)
CSAB: 
103236219(DDB2)
RRO: 
104668405(DDB2)
RBB: 
108521962(DDB2)
CJC: 
100390419(DDB2)
SBQ: 
101027903(DDB2)
MMU: 
107986(Ddb2)
RNO: 
100362121(Ddb2)
CGE: 
100756705(Ddb2)
NGI: 
103742505(Ddb2)
HGL: 
101715591(Ddb2)
CCAN: 
109696190(Ddb2)
OCU: 
100352386(DDB2)
TUP: 
102472614(DDB2)
CFA: 
483626(DDB2)
AML: 
100479738(DDB2)
UMR: 
103672315(DDB2)
FCA: 
101092211(DDB2)
PTG: 
102961097(DDB2)
AJU: 
106978021(DDB2)
BTA: 
519357(DDB2)
BOM: 
102272760(DDB2)
BIU: 
109569541(DDB2)
PHD: 
102338184(DDB2)
CHX: 
102171356(DDB2)
OAS: 
101116344(DDB2)
SSC: 
100513197(DDB2)
CFR: 
102523860(DDB2)
CDK: 
105106872(DDB2)
BACU: 
103017537(DDB2)
LVE: 
103079116(DDB2)
ECB: 
100051180(DDB2)
EPZ: 
103566732(DDB2)
EAI: 
106844006(DDB2)
MYB: 
102256502(DDB2)
MYD: 
102756511(DDB2)
HAI: 
109390202(DDB2)
RSS: 
109440541 109453668(DDB2)
PALE: 
102879479(DDB2)
LAV: 
100665802(DDB2)
MDO: 
100016157(DDB2) 100021792
SHR: 
100916232(DDB2)
OAA: 
100088212(DDB2)
GGA: 
423185(DDB2)
MGP: 
100548596(DDB2)
CJO: 
107314743(DDB2)
APLA: 
101791096(DDB2)
ACYG: 
106043656(DDB2)
TGU: 
100221888(DDB2)
GFR: 
102035276(DDB2)
FAB: 
101813959(DDB2)
PHI: 
102113625(DDB2)
PMAJ: 
107205447(DDB2)
CCW: 
104697960(DDB2)
FPG: 
101911160(DDB2)
FCH: 
102048021(DDB2)
CLV: 
102087151(DDB2)
AAM: 
106498364(DDB2)
ASN: 
102374438(DDB2)
AMJ: 
102570152(DDB2)
PSS: 
102461762(DDB2)
CMY: 
102941615(DDB2)
CPIC: 
101941863(DDB2)
ACS: 
100554400(ddb2)
PVT: 
110081991(DDB2)
PBI: 
103059573(DDB2)
GJA: 
107123208(DDB2)
XLA: 
108713786(ddb2.L) 108715228(ddb2.S)
XTR: 
493565(ddb2)
NPR: 
108791609(DDB2)
DRE: 
100004133(ddb2)
SRX: 
107708220 107738696
SANH: 
107686311(ddb2)
SGH: 
107583755 107596991
AMEX: 
103036503(ddb2)
TRU: 
101074409(ddb2)
TNG: 
GSTEN00012482G001
LCO: 
104922334(ddb2)
NCC: 
104945738(ddb2)
MZE: 
101480006(ddb2)
OLA: 
101159499(ddb2)
XMA: 
102226772(ddb2)
CSEM: 
103380265(ddb2)
LCF: 
108886614(ddb2)
HCQ: 
109519449(ddb2)
BPEC: 
110160813(ddb2)
SASA: 
106584815(ddb2)
ELS: 
105029687(ddb2)
SFM: 
108941276(ddb2)
BFO: 
BRAFLDRAFT_229150
SPU: 
100892716
APLC: 
110979161
SKO: 
100376707 100377457
PHU: 
Phum_PHUM473480
FCD: 
110853733
DPX: 
DAPPUDRAFT_39221
ISC: 
IscW_ISCW005034
TUT: 
107359138
LGI: 
LOTGIDRAFT_53959
CRG: 
105347658
LAK: 
106171869
AQU: 
105313700
ATH: 
AT5G58760(DDB2)
ALY: 
ARALYDRAFT_496001(DDB2)
CRB: 
CARUB_v10028053mg
CSAT: 
104726455 104736015 104761975
EUS: 
EUTSA_v10013126mg
BRP: 
103851625
BNA: 
106387387 106388037
BOE: 
106322698
THJ: 
104814912
CIT: 
102616830
CIC: 
CICLE_v10028135mg
TCC: 
18590503
GRA: 
105782070
GHI: 
107891962 107936460
EGR: 
104432651
GMX: 
100527914 100793506
PVU: 
PHAVU_008G261700g
VRA: 
106763140
VAR: 
108343861
CCAJ: 
109795279
MTR: 
MTR_5g070310
CAM: 
101499945
ADU: 
107458384
AIP: 
107609534
LJA: 
Lj2g3v2256250.1(Lj2g3v2256250.1) Lj2g3v2256250.2(Lj2g3v2256250.2)
LANG: 
109355773
FVE: 
101313874
PPER: 
18774206
PMUM: 
103320795
MDM: 
103447396
PXB: 
103939228 103960749
ZJU: 
107410820
CSV: 
101212319
CMO: 
103502024
MCHA: 
111017106
RCU: 
8286445
JCU: 
105630445
POP: 
POPTR_0001s25810g(POPTRDRAFT_829607)
VVI: 
100250121
SLY: 
101265575
SPEN: 
107029211
SOT: 
102582170
CANN: 
107842722
NTA: 
107759199 107760564
NSY: 
104244550
NTO: 
104111780
INI: 
109163509
SIND: 
105165177
BVG: 
104902748
NNU: 
104601256
OSA: 
4325482(P0019D06.8)
DOSA: 
Os01t0141700-01(Os01g0141700)
OBR: 
102710627
BDI: 
100842647
ATS: 
F775_16273
SBI: 
8060824
ZMA: 
100381699
SITA: 
101761501
PDA: 
103704021
EGU: 
105046232
MUS: 
103972285
DCT: 
110108807
ATR: 
18437948
SMO: 
SELMODRAFT_21554 SELMODRAFT_31884
PPP: 
PHYPADRAFT_188047
VCN: 
VOLCADRAFT_117128
CSL: 
COCSUDRAFT_2514
CVR: 
CHLNCDRAFT_26064
APRO: 
F751_3019
GSL: 
Gasu_51510
CCP: 
CHC_T00004000001
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Kulaksiz G, Reardon JT, Sancar A
  Title
Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.
  Journal
Mol Cell Biol 25:9784-92 (2005)
DOI:10.1128/MCB.25.22.9784-9792.2005
  Sequence
[hsa:1643]
Reference
  Authors
Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapic-Otrin V, Levine AS
  Title
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
  Journal
Proc Natl Acad Sci U S A 103:2588-93 (2006)
DOI:10.1073/pnas.0511160103
  Sequence
[hsa:1643]
Reference
PMID:8530102
  Authors
Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S
  Title
Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.
  Journal
Genomics 29:62-9 (1995)
DOI:10.1006/geno.1995.1215
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