KEGG   ORTHOLOGY: K10140Help
Entry
K10140                      KO                                     
Name
DDB2
Definition
DNA damage-binding protein 2
Pathway
Nucleotide excision repair
p53 signaling pathway
Ubiquitin mediated proteolysis
Hepatitis B
Module
M00385  
Cul4-DDB1-DDB2 complex
Disease
H00403  
Disorders of nucleotide excision repair
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10140  DDB2; DNA damage-binding protein 2
  Replication and repair
   03420 Nucleotide excision repair
    K10140  DDB2; DNA damage-binding protein 2
 Cellular Processes
  Cell growth and death
   04115 p53 signaling pathway
    K10140  DDB2; DNA damage-binding protein 2
 Human Diseases
  Infectious diseases
   05161 Hepatitis B
    K10140  DDB2; DNA damage-binding protein 2
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00385  Cul4-DDB1-DDB2 complex [BR:ko04121 ko03400]
     K10140  DDB2; DNA damage-binding protein 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  multi subunit Ring-finger type E3
   Cul4 complex
    target recognizing subunit (DCAF)
     K10140  DDB2; DNA damage-binding protein 2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K10140  DDB2; DNA damage-binding protein 2
BRITE hierarchy
Genes
HSA: 
1643(DDB2)
PTR: 
451165(DDB2)
PPS: 
100972583(DDB2)
GGO: 
101128036(DDB2)
PON: 
100454099(DDB2)
MCC: 
713813(DDB2)
MMU: 
107986(Ddb2)
RNO: 
100362121(Ddb2)
CGE: 
100756705(Ddb2)
HGL: 
101715591(Ddb2)
CFA: 
483626(DDB2)
AML: 
100479738
FCA: 
101092211(DDB2)
BTA: 
519357(DDB2)
SSC: 
100513197
ECB: 
100051180(DDB2)
MDO: 
100016157 100021792
SHR: 
100916232(DDB2)
OAA: 
100088212
GGA: 
423185(DDB2)
MGP: 
100548596
TGU: 
100221888(DDB2)
FAB: 
101813959(DDB2)
APLA: 
101791096(DDB2)
FPG: 
101911160(DDB2)
ACS: 
100554400
XTR: 
493565(ddb2)
DRE: 
100004133(ddb2)
TRU: 
101074409
MZE: 
101480006
OLA: 
101159499
BFO: 
BRAFLDRAFT_229150
SPU: 
100892716
PHU: 
Phum_PHUM473480
ISC: 
IscW_ISCW005034
ATH: 
AT5G58760(DDB2)
ALY: 
ARALYDRAFT_496001(DDB2)
GMX: 
100527914 100793506
MTR: 
MTR_5g070310
CAM: 
101499945
FVE: 
101313874
CSV: 
101212319
RCU: 
RCOM_0612100
POP: 
POPTR_829607
VVI: 
100250121
SLY: 
101265575
OSA: 
4325482
DOSA: 
Os01t0141700-01(Os01g0141700)
BDI: 
100842647
SBI: 
SORBI_03g006550(SORBIDRAFT_03g006550)
SITA: 
101761501
SMO: 
SELMODRAFT_21554 SELMODRAFT_31884
PPP: 
PHYPADRAFT_188047
VCN: 
VOLCADRAFT_117128
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Lee J, Zhou P.
  Title
DCAFs, the missing link of the CUL4-DDB1 ubiquitin ligase.
  Journal
Mol Cell 26:775-80 (2007)
Reference
  Authors
Kulaksiz G, Reardon JT, Sancar A
  Title
Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.
  Journal
Mol Cell Biol 25:9784-92 (2005)
Reference
  Authors
Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapic-Otrin V, Levine AS
  Title
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
  Journal
Proc Natl Acad Sci U S A 103:2588-93 (2006)
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