KEGG   ORTHOLOGY: K10151Help
Entry
K10151                      KO                                     

Name
CCND2
Definition
G1/S-specific cyclin-D2
Pathway
FoxO signaling pathway
Cell cycle
p53 signaling pathway
PI3K-Akt signaling pathway
Cellular senescence
Wnt signaling pathway
Hedgehog signaling pathway
Hippo signaling pathway
Focal adhesion
Jak-STAT signaling pathway
Prolactin signaling pathway
Measles
Human papillomavirus infection
HTLV-I infection
Transcriptional misregulation in cancer
Viral carcinogenesis
MicroRNAs in cancer
Module
M00692  
Cell cycle - G1/S transition
Disease
H00023  
Testicular cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04310 Wnt signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
   04340 Hedgehog signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
   04390 Hippo signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
   04630 Jak-STAT signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
   04068 FoxO signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
   04151 PI3K-Akt signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
 Cellular Processes
  Cell growth and death
   04110 Cell cycle
    K10151  CCND2; G1/S-specific cyclin-D2
   04115 p53 signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
   04218 Cellular senescence
    K10151  CCND2; G1/S-specific cyclin-D2
  Cellular community - eukaryotes
   04510 Focal adhesion
    K10151  CCND2; G1/S-specific cyclin-D2
 Organismal Systems
  Endocrine system
   04917 Prolactin signaling pathway
    K10151  CCND2; G1/S-specific cyclin-D2
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K10151  CCND2; G1/S-specific cyclin-D2
   05206 MicroRNAs in cancer
    K10151  CCND2; G1/S-specific cyclin-D2
   05203 Viral carcinogenesis
    K10151  CCND2; G1/S-specific cyclin-D2
  Infectious diseases
   05166 HTLV-I infection
    K10151  CCND2; G1/S-specific cyclin-D2
   05162 Measles
    K10151  CCND2; G1/S-specific cyclin-D2
   05165 Human papillomavirus infection
    K10151  CCND2; G1/S-specific cyclin-D2
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00692  Cell cycle - G1/S transition
     K10151  CCND2; G1/S-specific cyclin-D2
BRITE hierarchy
Genes
HSA: 
894(CCND2)
PTR: 
747123(CCND2)
PPS: 
100990850(CCND2)
GGO: 
101139749(CCND2)
PON: 
100457978(CCND2)
NLE: 
100585770(CCND2)
MCC: 
710379(CCND2)
MCF: 
102119572(CCND2)
CSAB: 
103218410(CCND2)
RRO: 
104658979(CCND2)
RBB: 
108536489(CCND2)
CJC: 
100390172(CCND2)
SBQ: 
101049141(CCND2)
MMU: 
12444(Ccnd2)
RNO: 
64033(Ccnd2)
CGE: 
100771544(Ccnd2)
NGI: 
103727547(Ccnd2)
HGL: 
101721480(Ccnd2)
CCAN: 
OCU: 
100009036(CCND2)
TUP: 
102479902(CCND2)
CFA: 
611782(CCND2)
AML: 
100471517(CCND2)
UMR: 
103675743(CCND2)
FCA: 
101090950(CCND2)
PTG: 
102970259(CCND2)
AJU: 
106965383(CCND2)
BTA: 
615414(CCND2)
BOM: 
102272576(CCND2)
BIU: 
109559745(CCND2)
PHD: 
102326040(CCND2)
CHX: 
102180657(CCND2)
OAS: 
100147799(CCND2)
SSC: 
397162(CCND2)
CDK: 
105091327(CCND2)
BACU: 
103002964(CCND2)
LVE: 
103077970(CCND2)
ECB: 
100051150(CCND2)
EPZ: 
103567717(CCND2)
EAI: 
106831500(CCND2)
MYB: 
102254218(CCND2)
MYD: 
102755701(CCND2)
HAI: 
109392488(CCND2)
RSS: 
109461009(CCND2)
PALE: 
102892640(CCND2)
LAV: 
100668070(CCND2)
MDO: 
100016259(CCND2)
SHR: 
OAA: 
GGA: 
374047(CCND2)
MGP: 
100550222(CCND2)
CJO: 
107318017(CCND2)
APLA: 
101802600(CCND2)
ACYG: 
106046294(CCND2)
TGU: 
100224096(CCND2)
GFR: 
102034688(CCND2)
FAB: 
101818224(CCND2)
PHI: 
102114518(CCND2)
CCW: 
104696177(CCND2)
FPG: 
101920354(CCND2)
FCH: 
102053549(CCND2)
CLV: 
102093196(CCND2)
AAM: 
106489562(CCND2)
ASN: 
102388617(CCND2)
AMJ: 
102564576(CCND2)
PSS: 
102462674(CCND2)
CMY: 
102931445(CCND2)
CPIC: 
101939404(CCND2)
GJA: 
107110411(CCND2)
XLA: 
373667(ccnd2.L) 734882(ccnd2.S)
XTR: 
100038071(ccnd2)
NPR: 
108788361(CCND2)
DRE: 
799608(ccnd2a)
SRX: 
SANH: 
SGH: 
IPU: 
100528326(ccnd2) 108279704(CCND2) 108280826 108281084(ccnd3)
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
103182468(ccnd3) 103185578(ccnd2)
BFO: 
CIN: 
SKO: 
100303589(ccnd)
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD15773(Dsim_GD15773)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
413183(CycD)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
NVI: 
100117434(cycD)
TCA: 
DPA: 
NVL: 
BMOR: 
100862781(cycD)
DPL: 
PXY: 
API: 
DNX: 
PHU: 
TUT: 
CEL: 
CBR: 
CBG02768(Cbr-cyd-1)
BMY: 
LOA: 
HRO: 
LGI: 
CRG: 
OBI: 
LAK: 
NVE: 
ADF: 
HMG: 
TAD: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1386336
  Authors
Xiong Y, Menninger J, Beach D, Ward DC
  Title
Molecular cloning and chromosomal mapping of CCND genes encoding human D-type cyclins.
  Journal
Genomics 13:575-84 (1992)
DOI:10.1016/0888-7543(92)90127-E
  Sequence
[hsa:894]
Reference
PMID:9178893
  Authors
Sweeney KJ, Sarcevic B, Sutherland RL, Musgrove EA
  Title
Cyclin D2 activates Cdk2 in preference to Cdk4 in human breast epithelial cells.
  Journal
Oncogene 14:1329-40 (1997)
DOI:10.1038/sj.onc.1200951
  Sequence
[hsa:894]
Reference
  Authors
Jena N, Deng M, Sicinska E, Sicinski P, Daley GQ
  Title
Critical role for cyclin D2 in BCR/ABL-induced proliferation of hematopoietic cells.
  Journal
Cancer Res 62:535-41 (2002)
  Sequence
[mmu:12444]

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