KEGG   ORTHOLOGY: K10160Help
Entry
K10160                      KO                                     

Name
TLR4
Definition
toll-like receptor 4
Pathway
NF-kappa B signaling pathway
HIF-1 signaling pathway
Phagosome
PI3K-Akt signaling pathway
Toll-like receptor signaling pathway
Pathogenic Escherichia coli infection
Salmonella infection
Pertussis
Legionellosis
Leishmaniasis
Chagas disease (American trypanosomiasis)
Malaria
Toxoplasmosis
Amoebiasis
Tuberculosis
Hepatitis B
Measles
Influenza A
Proteoglycans in cancer
Inflammatory bowel disease (IBD)
Rheumatoid arthritis
Disease
H00821  
Macular degeneration
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K10160  TLR4; toll-like receptor 4
   04066 HIF-1 signaling pathway
    K10160  TLR4; toll-like receptor 4
   04151 PI3K-Akt signaling pathway
    K10160  TLR4; toll-like receptor 4
 Cellular Processes
  Transport and catabolism
   04145 Phagosome
    K10160  TLR4; toll-like receptor 4
 Organismal Systems
  Immune system
   04620 Toll-like receptor signaling pathway
    K10160  TLR4; toll-like receptor 4
 Human Diseases
  Cancers
   05205 Proteoglycans in cancer
    K10160  TLR4; toll-like receptor 4
  Immune diseases
   05323 Rheumatoid arthritis
    K10160  TLR4; toll-like receptor 4
   05321 Inflammatiory bowel disease (IBD)
    K10160  TLR4; toll-like receptor 4
  Infectious diseases
   05130 Pathogenic Escherichia coli infection
    K10160  TLR4; toll-like receptor 4
   05132 Salmonella infection
    K10160  TLR4; toll-like receptor 4
   05133 Pertussis
    K10160  TLR4; toll-like receptor 4
   05134 Legionellosis
    K10160  TLR4; toll-like receptor 4
   05152 Tuberculosis
    K10160  TLR4; toll-like receptor 4
   05162 Measles
    K10160  TLR4; toll-like receptor 4
   05164 Influenza A
    K10160  TLR4; toll-like receptor 4
   05161 Hepatitis B
    K10160  TLR4; toll-like receptor 4
   05146 Amoebiasis
    K10160  TLR4; toll-like receptor 4
   05144 Malaria
    K10160  TLR4; toll-like receptor 4
   05145 Toxoplasmosis
    K10160  TLR4; toll-like receptor 4
   05140 Leishmaniasis
    K10160  TLR4; toll-like receptor 4
   05142 Chagas disease (American trypanosomiasis)
    K10160  TLR4; toll-like receptor 4
Cellular antigens [BR:ko04090]
 Proteins
  K10160  CD284, TLR4; toll-like receptor 4
BRITE hierarchy
Genes
HSA: 
7099(TLR4)
PTR: 
743242(TLR4)
PPS: 
100980644(TLR4)
GGO: 
PON: 
100457237(TLR4)
MCC: 
574360(TLR4)
MCF: 
102136906(TLR4)
MMU: 
21898(Tlr4)
RNO: 
29260(Tlr4)
CGE: 
100689329(Tlr4)
HGL: 
101715916(Tlr4)
TUP: 
102501464(TLR4)
CFA: 
403417(TLR4)
AML: 
FCA: 
493698(TLR4)
PTG: 
102959529(TLR4)
BTA: 
281536(TLR4)
BOM: 
102288174(TLR4)
PHD: 
102341029(TLR4)
CHX: 
100860955(TLR4)
SSC: 
399541(TLR4)
CFR: 
102522349(TLR4)
BACU: 
103015759(TLR4)
LVE: 
103074659(TLR4)
ECB: 
100066890(TLR4)
MYB: 
102253644(TLR4)
MYD: 
102756242(TLR4)
PALE: 
102897365(TLR4)
MDO: 
SHR: 
100927125(TLR4)
GGA: 
417241(TLR4)
MGP: 
TGU: 
100216357(TLR4)
FAB: 
101813378(TLR4)
PHI: 
102101350(TLR4)
APLA: 
101799388(TLR-4)
FPG: 
101922930(TLR4)
FCH: 
102055613(TLR4)
CLV: 
102096659(TLR4)
ASN: 
102383551(TLR4)
AMJ: 
PSS: 
102448887(TLR4)
CMY: 
102941701(TLR4)
ACS: 
PBI: 
DRE: 
403131(tlr4ba) 403132(tlr4bb) 795671(tlr4al)
BFO: 
TCA: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Anand RJ, Kohler JW, Cavallo JA, Li J, Dubowski T, Hackam DJ
  Title
Toll-like receptor 4 plays a role in macrophage phagocytosis during peritoneal sepsis.
  Journal
J Pediatr Surg 42:927-32; discussion 933 (2007)
  Sequence
[mmu:21898]
Reference
  Authors
Schmidt M, Raghavan B, Muller V, Vogl T, Fejer G, Tchaptchet S, Keck S, Kalis C, Nielsen PJ, Galanos C, Roth J, Skerra A, Martin SF, Freudenberg MA, Goebeler M
  Title
Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel.
  Journal
Nat Immunol 11:814-9 (2010)
  Sequence
[hsa:7099]

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