KEGG   ORTHOLOGY: K10251Help
Entry
K10251                      KO                                     
Name
HSD17B12, KAR, IFA38
Definition
17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase [EC:1.1.1.62 1.1.1.330]
Pathway
Fatty acid elongation
Steroid hormone biosynthesis
Biosynthesis of unsaturated fatty acids
Module
M00415  
Fatty acid biosynthesis, elongation, endoplasmic reticulum
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00062 Fatty acid elongation
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   00140 Steroid hormone biosynthesis
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
   01040 Biosynthesis of unsaturated fatty acids
    K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
KEGG pathway modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Fatty acid metabolism
    M00415  Fatty acid biosynthesis, elongation, endoplasmic reticulum
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.62  17beta-estradiol 17-dehydrogenase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
    1.1.1.330  very-long-chain 3-oxoacyl-CoA reductase
     K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
Lipid biosynthesis proteins [BR:ko01004]
 Fatty acid synthase
  Component type
   K10251  HSD17B12, KAR, IFA38; 17beta-estradiol 17-dehydrogenase / very-long-chain 3-oxoacyl-CoA reductase
BRITE hierarchy
Other DBs
Genes
HSA: 
51144(HSD17B12)
PTR: 
741010(HSD17B12)
PPS: 
100971612(HSD17B12)
GGO: 
101126579(HSD17B12)
PON: 
100439025(HSD17B12)
MMU: 
56348(Hsd17b12)
RNO: 
84013(Hsd17b12)
CFA: 
475939(HSD17B12)
AML: 
FCA: 
101082595(HSD17B12)
BTA: 
789567(HSD17B12)
SSC: 
100312972(HSD17B12)
ECB: 
100050075
MDO: 
100013277
SHR: 
100917982
OAA: 
100079057
GGA: 
769787(HSD17B12)
TGU: 
100223843(HSD17B12)
ACS: 
100557660
XLA: 
379747(hsd17b12-b) 495218(hsd17b12-a)
XTR: 
100127828 549988(hsd17b12)
DRE: 
322626(hsd17b12b) 327417(hsd17b12a)
TRU: 
101067779
OLA: 
101160884 101163971 101165994
BFO: 
BRAFLDRAFT_267231
CIN: 
445663(17-beta-HSD)
SPU: 
593779
DME: 
Dmel_CG1444
DPO: 
Dpse_GA12987
DAN: 
Dana_GF21190
DER: 
Dere_GG19668
DPE: 
Dper_GL18340
DSE: 
Dsec_GM11981
DSI: 
Dsim_GD16868
DWI: 
Dwil_GK10112
DYA: 
Dyak_GE15745
DGR: 
Dgri_GH13773 Dgri_GH24302
DMO: 
Dmoj_GI17177 Dmoj_GI21544
DVI: 
Dvir_GJ15689
AAG: 
AaeL_AAEL009634
CQU: 
CpipJ_CPIJ000572
TCA: 
660392
API: 
100167470
PHU: 
Phum_PHUM527040
ISC: 
IscW_ISCW003401
TSP: 
Tsp_02573
SMM: 
Smp_009430
NVE: 
NEMVE_v1g104066
HMG: 
100198713
TAD: 
TRIADDRAFT_26050
AQU: 
100635095
ATH: 
AT1G67730(KCR1)
ALY: 
ARALYDRAFT_475877
GMX: 
100814139 100817128
MTR: 
MTR_3g086210
CSV: 
101204853 101230976
RCU: 
RCOM_1082860
POP: 
POPTR_821856
VVI: 
100257681
OSA: 
4336202
DOSA: 
Os04t0483500-01(Os04g0483500)
BDI: 
100833506
SBI: 
SORBI_04g025020(SORBIDRAFT_04g025020)
ZMA: 
542359(gl8)
SMO: 
SELMODRAFT_166350 SELMODRAFT_234639 SELMODRAFT_234921 SELMODRAFT_269375
PPP: 
PHYPADRAFT_105480
CME: 
CMK172C
SCE: 
YBR159W(IFA38)
AGO: 
AGOS_ADR059C
ERC: 
Ecym_2565
KLA: 
KLLA0B09812g
LTH: 
KLTH0E11902g
PPA: 
PAS_chr4_0368
VPO: 
Kpol_513p6
ZRO: 
ZYRO0F08756g
CGR: 
CAGL0H07513g
NCS: 
NCAS_0B02360(NCAS0B02360)
NDI: 
NDAI_0C05330(NDAI0C05330)
TPF: 
TPHA_0L01460(TPHA0L01460)
TBL: 
TBLA_0H03430(TBLA0H03430)
TDL: 
TDEL_0B01260(TDEL0B01260)
KAF: 
KAFR_0E03020(KAFR0E03020)
DHA: 
DEHA2G10780g
PIC: 
PICST_79198(YBO9)
PGU: 
PGUG_04787
LEL: 
LELG_03198
CAL: 
CaO19.11340 CaO19.3859
CTP: 
CTRG_00620
CDU: 
CD36_31530
COT: 
CORT_0D05140
YLI: 
YALI0A06787g
CLU: 
CLUG_05344
NCR: 
NCU11297
SMP: 
SMAC_01146
PAN: 
PODANSg7603
TTT: 
THITE_2114503
MTM: 
MYCTH_2310645
MGR: 
MGG_05096
FGR: 
FG05670.1
NHE: 
NECHADRAFT_47054
VAL: 
VDBG_01135
SSL: 
SS1G_14012
BFU: 
BC1G_11561
ANI: 
AN5861.2
NFI: 
NFIA_086780
AFM: 
AFUA_2G11540
AOR: 
AOR_1_900014(AO090026000492)
ANG: 
ANI_1_488024(An02g03570)
AFV: 
AFLA_134430
ACT: 
ACLA_070510
PCS: 
Pc15g00160
CIM: 
CIMG_08188
CPW: 
CPC735_022060
PBL: 
PAAG_03693
URE: 
UREG_02440
ABE: 
ARB_01315
TVE: 
TRV_00021
AJE: 
HCAG_07127
PNO: 
SNOG_13627
PTE: 
PTT_14300
ZTR: 
MYCGRDRAFT_72043
TML: 
GSTUM_00006244001
SPO: 
SPAC4G9.15
CNE: 
CNI00690
CNB: 
CNBH0660
CGI: 
CGB_H1290C
PPL: 
POSPLDRAFT_27471
LBC: 
LACBIDRAFT_192627
MPR: 
MPER_13572
CCI: 
CC1G_02019
SCM: 
SCHCODRAFT_57944
UMA: 
UM04441.1
MGL: 
MGL_1839
PGR: 
PGTG_05352
EIN: 
Eint_081150
NCE: 
NCER_101810
MBR: 
MONBRDRAFT_38222
NGR: 
NAEGRDRAFT_80123
DDI: 
DDB_G0275049
DPP: 
DICPUDRAFT_78235
EHI: 
EHI_165070(127.t00009)
EDI: 
EDI_326520
PCB: 
PC000268.05.0
PVX: 
PVX_090140
PCY: 
PCYB_053540
TGO: 
TGME49_071890
LIF: 
LINJ_34_0010
LDO: 
LDBPK_340010
LMI: 
LMXM_33_0010
LBZ: 
LBRM_20_0090
GLA: 
GL50803_14626
PTI: 
PHATRDRAFT_25360
TPS: 
THAPSDRAFT_22650
PIF: 
PITG_00127
 » show all
TaxonomyKoalaUniProt
Reference
PMID:12087109 (S.cerevisiae)
  Authors
Han G, Gable K, Kohlwein SD, Beaudoin F, Napier JA, Dunn TM.
  Title
The Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.
  Journal
J Biol Chem 277:35440-9 (2002)
Reference
  Authors
Luu-The V, Tremblay P, Labrie F
  Title
Characterization of type 12 17beta-hydroxysteroid dehydrogenase, an isoform of type 3 17beta-hydroxysteroid dehydrogenase responsible for estradiol formation in women.
  Journal
Mol Endocrinol 20:437-43 (2006)
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