KEGG   ORTHOLOGY: K10437
Entry
K10437                      KO                                     
Symbol
PHAA, PHACA, CYP504A1
Name
phenylacetate 2-hydroxylase [EC:1.14.14.54]
Pathway
map00360  Phenylalanine metabolism
map00643  Styrene degradation
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Reaction
R05487  phenylacetate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00360 Phenylalanine metabolism
    K10437  PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
  09111 Xenobiotics biodegradation and metabolism
   00643 Styrene degradation
    K10437  PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K10437  PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.54  phenylacetate 2-hydroxylase
     K10437  PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, fungi type
  CYP504 family
   K10437  PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
Other DBs
COG: COG2124
GO: 0018631
Genes
PPA: PAS_chr3_0864
DHA: DEHA2D03168g
PIC: PICST_49761
PGU: PGUG_01534
SPAA: SPAPADRAFT_48604
CAL: CAALFM_C404360WA(CaO19.1411)
CTP: CTRG_03930
COT: CORT_0E04490
CDU: CD36_44030
CTEN: CANTEDRAFT_117516
MGR: MGG_04684
PGRI: PgNI_02910
MAW: MAC_08608
MAJ: MAA_10366
CMT: CCM_02553
MBE: MBM_06099
ABE: ARB_03198
TVE: TRV_03913
ZTR: MYCGRDRAFT_32609(CYP-22) MYCGRDRAFT_83782(CYP-33)
TASA: A1Q1_06336
CCAC: CcaHIS019_0108630(CcaverHIS019_0108630)
AG: AAF00011(pahA)
 » show all
Reference
  Authors
Mingot JM, Penalva MA, Fernandez-Canon JM
  Title
Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction.
  Journal
J Biol Chem 274:14545-50 (1999)
DOI:10.1074/jbc.274.21.14545
  Sequence
Reference
  Authors
Rodriguez-Saiz M, Barredo JL, Moreno MA, Fernandez-Canon JM, Penalva MA, Diez B.
  Title
Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains.
  Journal
J Bacteriol 183:5465-71 (2001)
DOI:10.1128/JB.183.19.5465-5471.2001
  Sequence

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