ORTHOLOGY: K10437 Help
Entry
Symbol
PHAA, PHACA, CYP504A1
Name
Pathway
map01120 Microbial metabolism in diverse environments
Reaction
R05487 phenylacetate,[reduced NADPH---hemoprotein reductase]:oxygen oxidoreductase (2-hydroxylating)
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09105 Amino acid metabolism
00360 Phenylalanine metabolism
K10437 PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
09111 Xenobiotics biodegradation and metabolism
00643 Styrene degradation
K10437 PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
09180 Brite Hierarchies
09181 Protein families: metabolism
00199 Cytochrome P450
K10437 PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
Enzymes [BR:ko01000 ]
1. Oxidoreductases
1.14 Acting on paired donors, with incorporation or reduction of molecular oxygen
1.14.14 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
1.14.14.54 phenylacetate 2-hydroxylase
K10437 PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
Cytochrome P450 [BR:ko00199 ]
Cytochrome P450, fungi type
CYP504 family
K10437 PHAA, PHACA, CYP504A1; phenylacetate 2-hydroxylase
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Mingot JM, Penalva MA, Fernandez-Canon JM
Title
Disruption of phacA, an Aspergillus nidulans gene encoding a novel cytochrome P450 monooxygenase catalyzing phenylacetate 2-hydroxylation, results in penicillin overproduction.
Journal
Sequence
Reference
Authors
Rodriguez-Saiz M, Barredo JL, Moreno MA, Fernandez-Canon JM, Penalva MA, Diez B.
Title
Reduced function of a phenylacetate-oxidizing cytochrome p450 caused strong genetic improvement in early phylogeny of penicillin-producing strains.
Journal
Sequence