KEGG   ORTHOLOGY: K10456Help
Entry
K10456                      KO                                     

Name
KLHL19, KEAP1, INRF2
Definition
kelch-like protein 19
Pathway
ko04120  Ubiquitin mediated proteolysis
ko05200  Pathways in cancer
ko05225  Hepatocellular carcinoma
ko05418  Fluid shear stress and atherosclerosis
Disease
H00048  Hepatocellular carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
   05225 Hepatocellular carcinoma
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
BRITE hierarchy
Genes
HSA: 9817(KEAP1)
PTR: 455706(KEAP1)
PPS: 100978540(KEAP1)
GGO: 101133771(KEAP1)
PON: 100173389(KEAP1)
NLE: 100588449(KEAP1)
MCC: 720514(KEAP1)
MCF: 102118980 102144881(KEAP1)
CSAB: 103233900(KEAP1)
RRO: 104670474(KEAP1)
RBB: 108517807 108539981(KEAP1)
CJC: 100409712(KEAP1)
SBQ: 101029728(KEAP1)
MMU: 50868(Keap1)
RNO: 117519(Keap1)
CGE: 100759410(Keap1)
NGI: 103747559(Keap1)
HGL: 101718777(Keap1)
CCAN: 109693174(Keap1)
OCU: 100346935(KEAP1)
TUP: 102490837(KEAP1)
CFA: 476713(KEAP1)
AML: 100467923(KEAP1)
UMR: 103678690(KEAP1)
ORO: 101378046(KEAP1)
FCA: 101091260(KEAP1)
PTG: 102969048(KEAP1)
AJU: 106980317(KEAP1)
BTA: 532791(KEAP1)
BOM: 102288117(KEAP1)
BIU: 109561590(KEAP1)
PHD: 102324180(KEAP1)
CHX: 102182688(KEAP1)
OAS: 101113845(KEAP1)
SSC: 100136900(KEAP1)
CFR: 102508840(KEAP1)
CDK: 105087634(KEAP1)
BACU: 103016742(KEAP1)
LVE: 103083057(KEAP1)
OOR: 101279074(KEAP1)
ECB: 100055128(KEAP1)
EPZ: 103562410(KEAP1)
EAI: 106846624(KEAP1)
MYB: 102247995(KEAP1)
MYD: 102753596(KEAP1)
HAI: 109391648(KEAP1)
RSS: 109454385(KEAP1)
PALE: 102894870(KEAP1)
LAV: 100662208(KEAP1)
TMU: 101356221
MDO: 100012710(KEAP1)
SHR: 100927230(KEAP1)
OAA: 100089243(KEAP1)
MGP: 104917088(KEAP1)
APLA: 106020668(KEAP1)
TGU: 100225218(KEAP1)
PHI: 102101438(KEAP1)
FPG: 101913139(KEAP1)
FCH: 102055868(KEAP1)
CLV: 102089090(KEAP1)
AAM: 106485710(KEAP1)
ASN: 102385105(KEAP1)
AMJ: 102575363(KEAP1)
CMY: 102940504(KEAP1)
CPIC: 101953638(KEAP1)
ACS: 100568087(keap1) 103282722
PVT: 110081732(KEAP1)
PBI: 103056705(KEAP1)
GJA: 107122756(KEAP1)
XTR: 100489128 493386(keap1)
NPR: 108787832 108803810(KEAP1)
DRE: 100003679(keap1b)
IPU: 108268010 108273170(keap1)
AMEX: 103040234 103045265(keap1)
TRU: 101063192 101073020(keap1)
NCC: 104943324(keap1) 104965954
MZE: 101465797 101473586(keap1)
OLA: 101159396 101160787(keap1)
XMA: 102226304 102236560(keap1)
PRET: 103458467 103468321(keap1)
NFU: 107382244(keap1) 107392120
CSEM: 103380129 103384180(keap1)
LCF: 108875034 108875866(keap1)
HCQ: 109511223(keap1) 109517426
BPEC: 110172628(keap1)
ELS: 105012141(keap1) 105019872
SFM: 108921418 108940127(keap1)
LCM: 102349551(KEAP1) 102358487
CMK: 103182030 103188845(keap1)
CIN: 100177101
APLC: 110989567
SKO: 100369057
DME: Dmel_CG3962(Keap1)
DSI: Dsimw501_GD20252(Dsim_GD20252)
MDE: 101898962
AAG: 5566481
AME: 411679
BIM: 100740524
BTER: 100644865
SOC: 105197418
AEC: 105148282
ACEP: 105624460
PBAR: 105429222
HST: 105189091
CFO: 105247947
LHU: 105675225
PGC: 109863072
NVI: 100123910
TCA: 655908
DPA: 109545476
NVL: 108568975
BMOR: 101738440
PMAC: 106714739
PRAP: 110995863
ZNE: 110836765
CRG: 105331401
MYI: 110443663
OBI: 106877646
SHX: MS3_07048
HMG: 100208712
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Furukawa M, Xiong Y.
  Title
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
  Journal
Mol Cell Biol 25:162-71 (2005)
DOI:10.1128/MCB.25.1.162-171.2005
  Sequence
[hsa:9817]
Reference
PMID:9887101
  Authors
Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M
  Title
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
  Journal
Genes Dev 13:76-86 (1999)
DOI:10.1101/gad.13.1.76
  Sequence
[mmu:50868]

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