KEGG   ORTHOLOGY: K10456Help
Entry
K10456                      KO                                     

Name
KLHL19, KEAP1, INRF2
Definition
kelch-like protein 19
Pathway
Ubiquitin mediated proteolysis
Fluid shear stress and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
 Human Diseases
  Cardiovascular diseases
   05418 Fluid shear stress and atherosclerosis
    K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     K10456  KLHL19, KEAP1, INRF2; kelch-like protein 19
BRITE hierarchy
Genes
HSA: 
9817(KEAP1)
PTR: 
455706(KEAP1)
PPS: 
100978540(KEAP1)
GGO: 
101133771(KEAP1)
PON: 
100173389(KEAP1)
NLE: 
100588449(KEAP1)
MCC: 
720514(KEAP1)
MCF: 
CSAB: 
103233900(KEAP1)
RRO: 
104670474(KEAP1)
RBB: 
CJC: 
100409712(KEAP1)
SBQ: 
101029728(KEAP1)
MMU: 
50868(Keap1)
RNO: 
117519(Keap1)
CGE: 
100759410(Keap1)
NGI: 
103747559(Keap1)
HGL: 
101718777(Keap1)
CCAN: 
109693174(Keap1)
OCU: 
100346935(KEAP1)
TUP: 
102490837(KEAP1)
CFA: 
476713(KEAP1)
AML: 
100467923(KEAP1)
UMR: 
103678690(KEAP1)
FCA: 
101091260(KEAP1)
PTG: 
102969048(KEAP1)
AJU: 
106980317(KEAP1)
BTA: 
532791(KEAP1)
BOM: 
102288117(KEAP1)
BIU: 
109561590(KEAP1)
PHD: 
102324180(KEAP1)
CHX: 
102182688(KEAP1)
OAS: 
101113845(KEAP1)
SSC: 
100136900(KEAP1)
CFR: 
102508840(KEAP1)
CDK: 
105087634(KEAP1)
BACU: 
103016742(KEAP1)
LVE: 
103083057(KEAP1)
ECB: 
100055128(KEAP1)
EPZ: 
103562410(KEAP1)
EAI: 
106846624(KEAP1)
MYB: 
102247995(KEAP1)
MYD: 
102753596(KEAP1)
HAI: 
109391648(KEAP1)
RSS: 
109454385(KEAP1)
PALE: 
102894870(KEAP1)
LAV: 
100662208(KEAP1)
MDO: 
100012710(KEAP1)
SHR: 
100927230(KEAP1)
OAA: 
100089243(KEAP1)
MGP: 
104917088(KEAP1)
APLA: 
106020668(KEAP1)
TGU: 
100225218(KEAP1)
PHI: 
102101438(KEAP1)
FPG: 
101913139(KEAP1)
FCH: 
102055868(KEAP1)
CLV: 
102089090(KEAP1)
AAM: 
106485710(KEAP1)
ASN: 
102385105(KEAP1)
AMJ: 
102575363(KEAP1)
CMY: 
102940504(KEAP1)
CPIC: 
101953638(KEAP1)
ACS: 
PBI: 
103056705(KEAP1)
GJA: 
107122756(KEAP1)
XLA: 
XTR: 
NPR: 
DRE: 
100003679(keap1b)
SRX: 
SANH: 
SGH: 
IPU: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
CSEM: 
LCF: 
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
BFO: 
CIN: 
SPU: 
SKO: 
DME: 
DPO: 
DAN: 
DER: 
DPE: 
DSE: 
DSI: 
Dsimw501_GD20252(Dsim_GD20252)
DWI: 
DYA: 
DGR: 
DMO: 
DVI: 
MDE: 
AGA: 
AAG: 
CQU: 
AME: 
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PXY: 
PHU: 
DPX: 
ISC: 
LGI: 
CRG: 
OBI: 
LAK: 
SMM: 
ADF: 
HMG: 
MBR: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Furukawa M, Xiong Y.
  Title
BTB protein Keap1 targets antioxidant transcription factor Nrf2 for ubiquitination by the Cullin 3-Roc1 ligase.
  Journal
Mol Cell Biol 25:162-71 (2005)
DOI:10.1128/MCB.25.1.162-171.2005
  Sequence
[hsa:9817]
Reference
PMID:9887101
  Authors
Itoh K, Wakabayashi N, Katoh Y, Ishii T, Igarashi K, Engel JD, Yamamoto M
  Title
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain.
  Journal
Genes Dev 13:76-86 (1999)
DOI:10.1101/gad.13.1.76
  Sequence
[mmu:50868]

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