KEGG   ORTHOLOGY: K10630Help
Entry
K10630                      KO                                     

Name
RBCK1, HOIL1
Definition
RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.27]
Pathway
Necroptosis
NOD-like receptor signaling pathway
Disease
H01744  
Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
  Multi subunit Ring-finger type E3
   LUBAC complex
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
BRITE hierarchy
Genes
HSA: 
10616(RBCK1)
PTR: 
458025(RBCK1)
PPS: 
100981890(RBCK1)
GGO: 
PON: 
100438712(RBCK1)
NLE: 
100603577(RBCK1)
MCC: 
714692(RBCK1)
MCF: 
102126740(RBCK1)
CSAB: 
103247827(RBCK1)
RRO: 
104660808(RBCK1)
RBB: 
108544535(RBCK1)
CJC: 
100411512(RBCK1)
SBQ: 
101038299(RBCK1)
MMU: 
24105(Rbck1)
RNO: 
60383(Rbck1)
CGE: 
100761016(Rbck1)
NGI: 
103751631(Rbck1)
HGL: 
101721667(Rbck1)
CCAN: 
109687017(Rbck1)
OCU: 
100347560(RBCK1)
TUP: 
102473168(RBCK1)
CFA: 
485818(RBCK1)
AML: 
100471387(RBCK1)
UMR: 
103674489(RBCK1)
ORO: 
101374350(RBCK1)
FCA: 
101083505(RBCK1)
PTG: 
102970756(RBCK1)
AJU: 
106985976(RBCK1)
BTA: 
504400(RBCK1)
BOM: 
102280624(RBCK1)
BIU: 
109567335(RBCK1)
PHD: 
102333071(RBCK1)
CHX: 
102181220(RBCK1)
OAS: 
101122207(RBCK1)
SSC: 
100519985(RBCK1)
CFR: 
102513471(RBCK1)
CDK: 
105100807(RBCK1)
BACU: 
103000245(RBCK1)
LVE: 
103084814(RBCK1)
ECB: 
100067987(RBCK1)
EPZ: 
103556916(RBCK1)
EAI: 
106833755(RBCK1)
MYB: 
102252422(RBCK1)
MYD: 
102759068(RBCK1)
HAI: 
109384455(RBCK1)
RSS: 
109460116(RBCK1)
PALE: 
102884021(RBCK1)
LAV: 
100654220(RBCK1)
TMU: 
MDO: 
100011102(RBCK1)
SHR: 
100919033(RBCK1)
MGP: 
104915434(RBCK1)
CJO: 
APLA: 
ACYG: 
FAB: 
PHI: 
102106906(SHARPIN)
FPG: 
101917453(SHARPIN)
FCH: 
102047647(SHARPIN)
CLV: 
ASN: 
102374341(SHARPIN) 102381829(RBCK1)
AMJ: 
CMY: 
102933957(RBCK1)
CPIC: 
101952313(SHARPIN) 101954121(RBCK1)
ACS: 
100562899(rbck1) 100564158(sharpin)
PVT: 
PBI: 
GJA: 
107117859(SHARPIN) 107119331(RBCK1)
XLA: 
XTR: 
100491300(rbck1)
NPR: 
108802101(RBCK1)
DRE: 
431715(rbck1) 569903(shrprbck1r)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
TNG: 
LCO: 
NCC: 
MZE: 
OLA: 
XMA: 
PRET: 
NFU: 
CSEM: 
LCF: 
HCQ: 
BPEC: 
SASA: 
ELS: 
SFM: 
LCM: 
102349730(SHARPIN) 102349954(RBCK1)
CMK: 
103179690(sharpin) 103188626(rbck1)
BFO: 
CIN: 
100169995(zf(ring/rbz)-1)
SPU: 
APLC: 
AGA: 
AAG: 
CQU: 
AME: 
410462(GB17157)
BIM: 
BTER: 
SOC: 
AEC: 
ACEP: 
PBAR: 
HST: 
CFO: 
LHU: 
PGC: 
NVI: 
TCA: 
DPA: 
NVL: 
BMOR: 
DPL: 
PMAC: 
PRAP: 
API: 
DNX: 
PHU: 
ZNE: 
FCD: 
DPX: 
ISC: 
TUT: 
HRO: 
LGI: 
CRG: 
MYI: 
OBI: 
LAK: 
NVE: 
EPA: 
ADF: 
HMG: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu HB
  Title
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.
  Journal
Cell Res 18:1096-104 (2008)
DOI:10.1038/cr.2008.277
Reference
  Authors
Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K
  Title
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.
  Journal
Nat Cell Biol 5:336-40 (2003)
DOI:10.1038/ncb952
  Sequence
[hsa:10616]

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