KEGG   ORTHOLOGY: K10771Help
Entry
K10771                      KO                                     
Name
APEX1
Definition
AP endonuclease 1 [EC:4.2.99.18]
Pathway
Base excision repair
Module
M00296  
BER complex
Brite
KEGG Orthology (KO) [BR:ko00001]
 Genetic Information Processing
  Replication and repair
   03410 Base excision repair
    K10771  APEX1; AP endonuclease 1
KEGG pathway modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Repair system
    M00296  BER complex [BR:ko03400]
     K10771  APEX1; AP endonuclease 1
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.99  Other carbon-oxygen lyases
    4.2.99.18  DNA-(apurinic or apyrimidinic site) lyase
     K10771  APEX1; AP endonuclease 1
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   BER (base exicision repair)
    AP endonucleases
     K10771  APEX1; AP endonuclease 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
328(APEX1)
PTR: 
465200(APEX1)
PPS: 
100987860(APEX1)
GGO: 
101131302(APEX1)
PON: 
100453495(APEX1)
MCC: 
702757(APEX1)
MMU: 
11792(Apex1)
RNO: 
79116(Apex1)
CFA: 
482558(APEX1)
AML: 
FCA: 
101101318(APEX1)
BTA: 
281630(APEX1)
SSC: 
100154728(APEX1)
ECB: 
100072588
MDO: 
100029539
SHR: 
100924341(APEX1)
OAA: 
100086075
GGA: 
100431102(APEX1)
TGU: 
100230648
ACS: 
100554177
XLA: 
432324(apex1)
XTR: 
394929(apex1)
DRE: 
406730(apex1)
TRU: 
101069391
OLA: 
101172621
BFO: 
BRAFLDRAFT_225146
CIN: 
100176572
SPU: 
584564
DME: 
Dmel_CG3178(Rrp1)
AGA: 
AgaP_AGAP009587
AAG: 
AaeL_AAEL010781
CQU: 
CpipJ_CPIJ012006
AME: 
551153(Rrp1)
NVI: 
100121546(NV11148)
TCA: 
655158 658053 664052
API: 
100166616
PHU: 
Phum_PHUM026780
CEL: 
CELE_R09B3.1(exo-3) CELE_T05H10.2(apn-1)
CBR: 
CBG18693(Cbr-exo-3)
BMY: 
Bm1_22525 Bm1_24435
TSP: 
Tsp_01310
SMM: 
Smp_051320
NVE: 
NEMVE_v1g129266 NEMVE_v1g129329
HMG: 
100201725
TAD: 
TRIADDRAFT_60990 TRIADDRAFT_62597
AQU: 
100634205
SMO: 
SELMODRAFT_103806 SELMODRAFT_99746
CRE: 
CHLREDRAFT_143864
VCN: 
VOLCADRAFT_56112
OTA: 
Ot03g02610
CME: 
CMG142C CML016C
SCE: 
YKL114C(APN1)
AGO: 
AGOS_ABL054C
ERC: 
Ecym_7413
KLA: 
KLLA0C14256g
LTH: 
KLTH0D05104g
PPA: 
PAS_chr3_0810
VPO: 
Kpol_1033p64
ZRO: 
ZYRO0G02838g
CGR: 
CAGL0K11528g
NCS: 
NCAS_0A04450(NCAS0A04450)
NDI: 
NDAI_0K01490(NDAI0K01490)
TPF: 
TPHA_0G03000(TPHA0G03000)
TBL: 
TBLA_0I01300(TBLA0I01300)
TDL: 
TDEL_0A02340(TDEL0A02340)
KAF: 
KAFR_0D03110(KAFR0D03110)
DHA: 
DEHA2F13838g
PIC: 
PICST_30161
PGU: 
PGUG_00958
LEL: 
LELG_02700
CAL: 
CaO19.7428(APN1)
CTP: 
CTRG_02221
CDU: 
CD36_86400
COT: 
CORT_0C04060
YLI: 
YALI0C12144g
CLU: 
CLUG_05578
NCR: 
NCU10044
SMP: 
SMAC_00377
PAN: 
PODANSg5747
TTT: 
THITE_2113782
MTM: 
MYCTH_114166
MGR: 
MGG_10609
FGR: 
FG01348.1
NHE: 
NECHADRAFT_74423
VAL: 
VDBG_05893
SSL: 
SS1G_13282
BFU: 
BC1G_06700
ANI: 
AN3947.2
NFI: 
NFIA_053780
AFM: 
AFUA_6G08110
AOR: 
AOR_1_208154
ANG: 
ANI_1_1696094(An11g02010)
AFV: 
AFLA_036870
ACT: 
ACLA_082550
CIM: 
CIMG_01149
CPW: 
CPC735_052320
PBL: 
PAAG_01173
URE: 
UREG_01084
ABE: 
ARB_07906
TVE: 
TRV_04130
AJE: 
HCAG_05891
PNO: 
SNOG_15845
PTE: 
PTT_04322
ZTR: 
MYCGRDRAFT_86647
TML: 
GSTUM_00006772001
CNE: 
CNH01280
CNB: 
CNBL1230
CGI: 
CGB_L1330C
PPL: 
POSPLDRAFT_34471 POSPLDRAFT_91820
LBC: 
LACBIDRAFT_251065 LACBIDRAFT_306129
MPR: 
MPER_06696
CCI: 
CC1G_13815
SCM: 
SCHCODRAFT_51823
UMA: 
UM00308.1
MGL: 
MGL_4225
PGR: 
PGTG_14718
NGR: 
NAEGRDRAFT_58770
DDI: 
DDB_G0277701(apeA) DDB_G0279923(apnA)
EHI: 
EHI_046670(213.t00004)
EDI: 
EDI_124000
PFA: 
PF13_0176(apn1)
PFD: 
PFDG_02884
PFH: 
PFHG_02836
PYO: 
PY05725
PCB: 
PC102725.00.0
PBE: 
PB103684.00.0
PKN: 
PKH_122030
PVX: 
PVX_082560
PCY: 
PCYB_123010
TAN: 
TA12590
TPV: 
TP02_0334
BBO: 
BBOV_III005900(17.m07523)
CPV: 
cgd1_310
CHO: 
Chro.10041
TGO: 
TGME49_088680
PTM: 
GSPATT00017292001
TBR: 
Tb927.8.5510(Tb08.26E13.110)
TCR: 
507083.30 509901.170
LMA: 
LMJF_16_0680
LIF: 
LINJ_16_0680
LDO: 
LDBPK_160680
LMI: 
LMXM_16_0680
LBZ: 
LBRM_16_0670
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Tell G, Fantini D, Quadrifoglio F
  Title
Understanding different functions of mammalian AP endonuclease (APE1) as a promising tool for cancer treatment.
  Journal
Cell Mol Life Sci 67:3589-608 (2010)
Reference
  Authors
Fantini D, Vascotto C, Marasco D, D'Ambrosio C, Romanello M, Vitagliano L, Pedone C, Poletto M, Cesaratto L, Quadrifoglio F, Scaloni A, Radicella JP, Tell G
  Title
Critical lysine residues within the overlooked N-terminal domain of human APE1 regulate its biological functions.
  Journal
Nucleic Acids Res 38:8239-56 (2010)
Reference
  Authors
Barnes T, Kim WC, Mantha AK, Kim SE, Izumi T, Mitra S, Lee CH
  Title
Identification of Apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA.
  Journal
Nucleic Acids Res 37:3946-58 (2009)
Reference
  Authors
Laerdahl JK, Korvald H, Nilsen L, Dahl-Michelsen K, Rognes T, Bjoras M, Alseth I
  Title
Schizosaccharomyces pombe encodes a mutated AP endonuclease 1.
  Journal
DNA Repair (Amst) 10:296-305 (2011)
DBGET integrated database retrieval system