KEGG   ORTHOLOGY: K11217Help
Entry
K11217                      KO                                     

Name
JAK1
Definition
Janus kinase 1 [EC:2.7.10.2]
Pathway
EGFR tyrosine kinase inhibitor resistance
PI3K-Akt signaling pathway
Necroptosis
Osteoclast differentiation
Signaling pathways regulating pluripotency of stem cells
NOD-like receptor signaling pathway
Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Th17 cell differentiation
Leishmaniasis
Toxoplasmosis
Tuberculosis
Hepatitis C
Hepatitis B
Measles
Influenza A
Human papillomavirus infection
HTLV-I infection
Kaposi's sarcoma-associated herpesvirus infection
Herpes simplex infection
Epstein-Barr virus infection
Pathways in cancer
Viral carcinogenesis
Pancreatic cancer
Module
M00684  
JAK-STAT signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K11217  JAK1; Janus kinase 1
   04151 PI3K-Akt signaling pathway
    K11217  JAK1; Janus kinase 1
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    K11217  JAK1; Janus kinase 1
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11217  JAK1; Janus kinase 1
 Organismal Systems
  Immune system
   04621 NOD-like receptor signaling pathway
    K11217  JAK1; Janus kinase 1
   04658 Th1 and Th2 cell differentiation
    K11217  JAK1; Janus kinase 1
   04659 Th17 cell differentiation
    K11217  JAK1; Janus kinase 1
  Development
   04380 Osteoclast differentiation
    K11217  JAK1; Janus kinase 1
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K11217  JAK1; Janus kinase 1
   05203 Viral carcinogenesis
    K11217  JAK1; Janus kinase 1
   05212 Pancreatic cancer
    K11217  JAK1; Janus kinase 1
  Infectious diseases
   05152 Tuberculosis
    K11217  JAK1; Janus kinase 1
   05166 HTLV-I infection
    K11217  JAK1; Janus kinase 1
   05162 Measles
    K11217  JAK1; Janus kinase 1
   05164 Influenza A
    K11217  JAK1; Janus kinase 1
   05161 Hepatitis B
    K11217  JAK1; Janus kinase 1
   05160 Hepatitis C
    K11217  JAK1; Janus kinase 1
   05168 Herpes simplex infection
    K11217  JAK1; Janus kinase 1
   05167 Kaposi's sarcoma-associated herpesvirus infection
    K11217  JAK1; Janus kinase 1
   05169 Epstein-Barr virus infection
    K11217  JAK1; Janus kinase 1
   05165 Human papillomavirus infection
    K11217  JAK1; Janus kinase 1
   05145 Toxoplasmosis
    K11217  JAK1; Janus kinase 1
   05140 Leishmaniasis
    K11217  JAK1; Janus kinase 1
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K11217  JAK1; Janus kinase 1
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K11217  JAK1; Janus kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11217  JAK1; Janus kinase 1
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  JAK family [OT]
   K11217  JAK1; Janus kinase 1
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3716(JAK1)
PTR: 
743373(JAK1)
PPS: 
100972202(JAK1)
GGO: 
101133331(JAK1)
PON: 
100433477(JAK1)
NLE: 
100588162(JAK1)
MCC: 
677689(JAK1)
MCF: 
102123983(JAK1)
CSAB: 
103224682(JAK1)
RRO: 
104668074(JAK1)
RBB: 
108532886(JAK1)
CJC: 
100385835(JAK1)
SBQ: 
101031615(JAK1)
MMU: 
16451(Jak1)
RNO: 
84598(Jak1)
CGE: 
100754824(Jak1)
NGI: 
103732475(Jak1)
HGL: 
101710283(Jak1)
CCAN: 
109699504(Jak1)
OCU: 
100352594(JAK1)
TUP: 
102471806(JAK1)
CFA: 
442952(JAK1)
AML: 
100473460(JAK1)
UMR: 
103663059(JAK1)
ORO: 
101365648(JAK1)
FCA: 
101084377(JAK1)
PTG: 
102960189(JAK1)
AJU: 
106983739(JAK1)
BTA: 
537201(JAK1)
BOM: 
102286137(JAK1)
BIU: 
109556202(JAK1)
PHD: 
102330456(JAK1)
CHX: 
102182846(JAK1)
OAS: 
101110716(JAK1)
SSC: 
397202(JAK1)
CFR: 
102519873(JAK1)
CDK: 
105107124(JAK1)
BACU: 
103004050(JAK1)
LVE: 
103072682(JAK1)
ECB: 
100054008(JAK1)
EPZ: 
103560394(JAK1)
EAI: 
106838751(JAK1)
MYB: 
102260801(JAK1)
MYD: 
102756517(JAK1)
HAI: 
109384938(JAK1)
RSS: 
109447340(JAK1)
PALE: 
102880365(JAK1)
LAV: 
100655548(JAK1)
TMU: 
MDO: 
100031307(JAK1)
SHR: 
100916991(JAK1)
GGA: 
395681(JAK1)
MGP: 
CJO: 
107317736(JAK1)
APLA: 
101794879(JAK1)
ACYG: 
106043591(JAK1)
TGU: 
100228920(JAK1)
GFR: 
102041288(JAK1)
FAB: 
101805872(JAK1)
PHI: 
102100416(JAK1)
PMAJ: 
107208260(JAK1)
CCW: 
104695136(JAK1)
FPG: 
101921412(JAK1)
FCH: 
102048655(JAK1)
CLV: 
102098386(JAK1)
EGZ: 
104123929(JAK1)
AAM: 
106487285(JAK1)
ASN: 
102382170(JAK1)
AMJ: 
106736893(JAK1)
PSS: 
102454892(JAK1)
CMY: 
102944623(JAK1)
CPIC: 
101947775(JAK1)
ACS: 
100559328(jak1)
PVT: 
110085695(JAK1)
PBI: 
103059257(JAK1)
GJA: 
107124605(JAK1)
XLA: 
XTR: 
100038172(jak1)
NPR: 
108792339(JAK1)
DRE: 
30280(jak1)
SRX: 
SANH: 
SGH: 
CCAR: 
IPU: 
AMEX: 
TRU: 
101072065(jak1)
TNG: 
LCO: 
NCC: 
104950514(jak1)
MZE: 
101464192(jak1)
OLA: 
101175389(jak1)
XMA: 
102225542(jak1)
PRET: 
103463041(jak1)
CSEM: 
103395542(jak1)
LCF: 
108897047(jak1)
HCQ: 
109518981(jak1)
BPEC: 
110167954(jak1)
SASA: 
ELS: 
SFM: 
LCM: 
CMK: 
103189591(jak1)
OBI: 
AQU: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:1848670
  Authors
Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A
  Title
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.
  Journal
Mol Cell Biol 11:2057-65 (1991)
DOI:10.1128/MCB.11.4.2057
  Sequence
[hsa:3716]

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