KEGG   ORTHOLOGY: K11218Help
Entry
K11218                      KO                                     
Name
JAK3
Definition
Janus kinase 3 [EC:2.7.10.2]
Pathway
Chemokine signaling pathway
PI3K-Akt signaling pathway
Jak-STAT signaling pathway
Measles
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Disease
H00091  
T-B+Severe combined immunodeficiencies (SCIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K11218  JAK3; Janus kinase 3
   04151 PI3K-Akt signaling pathway
    K11218  JAK3; Janus kinase 3
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K11218  JAK3; Janus kinase 3
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K11218  JAK3; Janus kinase 3
  Infectious diseases
   05166 HTLV-I infection
    K11218  JAK3; Janus kinase 3
   05162 Measles
    K11218  JAK3; Janus kinase 3
   05169 Epstein-Barr virus infection
    K11218  JAK3; Janus kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11218  JAK3; Janus kinase 3
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  JAK family
   K11218  JAK3; Janus kinase 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3718(JAK3)
PTR: 
455848(JAK3)
PPS: 
100972035(JAK3)
GGO: 
101153232(JAK3)
PON: 
100433988(JAK3)
MCC: 
MMU: 
16453(Jak3)
RNO: 
25326(Jak3)
CFA: 
610004(JAK3)
AML: 
FCA: 
101092339(JAK3)
BTA: 
538276(JAK3)
SSC: 
100518649(JAK3)
ECB: 
100147451(JAK3)
MDO: 
100010720
SHR: 
100920108(JAK3)
GGA: 
395845(JAK3)
XTR: 
100135373(jak3)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8022485
  Authors
Johnston JA, Kawamura M, Kirken RA, Chen YQ, Blake TB, Shibuya K, Ortaldo JR, McVicar DW, O'Shea JJ
  Title
Phosphorylation and activation of the Jak-3 Janus kinase in response to interleukin-2.
  Journal
Nature 370:151-3 (1994)
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