KEGG   ORTHOLOGY: K11218Help
Entry
K11218                      KO                                     

Name
JAK3
Definition
Janus kinase 3 [EC:2.7.10.2]
Pathway
Chemokine signaling pathway
PI3K-Akt signaling pathway
Signaling pathways regulating pluripotency of stem cells
Jak-STAT signaling pathway
Th1 and Th2 cell differentiation
Measles
HTLV-I infection
Epstein-Barr virus infection
Viral carcinogenesis
Module
M00684  
JAK-STAT signaling
Disease
H00091  
T-B+Severe combined immunodeficiencies (SCIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K11218  JAK3; Janus kinase 3
   04151 PI3K-Akt signaling pathway
    K11218  JAK3; Janus kinase 3
 Cellular Processes
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11218  JAK3; Janus kinase 3
 Organismal Systems
  Immune system
   04658 Th1 and Th2 cell differentiation
    K11218  JAK3; Janus kinase 3
   04062 Chemokine signaling pathway
    K11218  JAK3; Janus kinase 3
 Human Diseases
  Cancers
   05203 Viral carcinogenesis
    K11218  JAK3; Janus kinase 3
  Infectious diseases
   05166 HTLV-I infection
    K11218  JAK3; Janus kinase 3
   05162 Measles
    K11218  JAK3; Janus kinase 3
   05169 Epstein-Barr virus infection
    K11218  JAK3; Janus kinase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K11218  JAK3; Janus kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11218  JAK3; Janus kinase 3
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  JAK family [OT]
   K11218  JAK3; Janus kinase 3
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
3718(JAK3)
PPS: 
100972035(JAK3)
GGO: 
101153232(JAK3)
PON: 
100433988(JAK3)
NLE: 
100603367(JAK3)
MCC: 
720040(JAK3)
MCF: 
102134669(JAK3)
CSAB: 
103234155(JAK3)
RRO: 
104660959(JAK3)
CJC: 
100397491(JAK3)
SBQ: 
101034707(JAK3)
MMU: 
16453(Jak3)
RNO: 
25326(Jak3)
CGE: 
100773497(Jak3)
NGI: 
103726892(Jak3)
HGL: 
101715472(Jak3)
TUP: 
102471949(JAK3)
CFA: 
610004(JAK3)
AML: 
100474005(JAK3)
UMR: 
103675167(JAK3)
FCA: 
101092339(JAK3)
PTG: 
102966280(JAK3)
BTA: 
538276(JAK3)
BOM: 
102286011(JAK3)
PHD: 
102327649(JAK3)
CHX: 
102171504(JAK3)
OAS: 
101112816(JAK3)
SSC: 
100518649(JAK3)
CFR: 
102503866(JAK3)
BACU: 
103012385(JAK3)
LVE: 
103081519(JAK3)
ECB: 
100147451(JAK3)
MYB: 
102241153(JAK3)
MYD: 
102767426(JAK3)
PALE: 
102898620(JAK3)
LAV: 
100665896(JAK3)
MDO: 
100010720(JAK3)
SHR: 
100920108(JAK3)
OAA: 
100085612(JAK3)
GGA: 
395845(JAK3)
MGP: 
100544996(JAK3)
CJO: 
107325427(JAK3)
GFR: 
102039894(JAK3)
PHI: 
102110608(JAK3)
FPG: 
101914306(JAK3)
FCH: 
102054762(JAK3)
CLV: 
102096086(JAK3)
AAM: 
106486617(JAK3)
ASN: 
102382453(JAK3)
AMJ: 
102570658(JAK3)
PSS: 
102443764(JAK3)
CMY: 
102943900(JAK3)
PBI: 
103062083(JAK3)
GJA: 
107120632(JAK3)
XTR: 
100135373(jak3)
SPAR: 
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8022790
  Authors
Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR, et al.
  Title
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
  Journal
Proc Natl Acad Sci U S A 91:6374-8 (1994)
  Sequence
[hsa:3718]

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