KEGG   ORTHOLOGY: K11218Help
Entry
K11218                      KO                                     

Name
JAK3
Definition
Janus kinase 3 [EC:2.7.10.2]
Pathway
ko04062  Chemokine signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04217  Necroptosis
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04630  Jak-STAT signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko05162  Measles
ko05166  HTLV-I infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05223  Non-small cell lung cancer
Module
M00684  JAK-STAT signaling
Disease
H00091  T-B+Severe combined immunodeficiencies (SCIDs)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K11218  JAK3; Janus kinase 3
   04151 PI3K-Akt signaling pathway
    K11218  JAK3; Janus kinase 3
 Cellular Processes
  Cell growth and death
   04217 Necroptosis
    K11218  JAK3; Janus kinase 3
  Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11218  JAK3; Janus kinase 3
 Organismal Systems
  Immune system
   04658 Th1 and Th2 cell differentiation
    K11218  JAK3; Janus kinase 3
   04659 Th17 cell differentiation
    K11218  JAK3; Janus kinase 3
   04062 Chemokine signaling pathway
    K11218  JAK3; Janus kinase 3
 Human Diseases
  Cancers
   05200 Pathways in cancer
    K11218  JAK3; Janus kinase 3
   05203 Viral carcinogenesis
    K11218  JAK3; Janus kinase 3
   05223 Non-small cell lung cancer
    K11218  JAK3; Janus kinase 3
  Infectious diseases
   05166 HTLV-I infection
    K11218  JAK3; Janus kinase 3
   05162 Measles
    K11218  JAK3; Janus kinase 3
   05169 Epstein-Barr virus infection
    K11218  JAK3; Janus kinase 3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00684  JAK-STAT signaling
     K11218  JAK3; Janus kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11218  JAK3; Janus kinase 3
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   K11218  JAK3; Janus kinase 3
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 3718(JAK3)
PPS: 100972035(JAK3)
GGO: 101153232(JAK3)
PON: 100433988(JAK3)
NLE: 100603367(JAK3)
MCC: 720040(JAK3)
MCF: 102134669(JAK3)
CSAB: 103234155(JAK3)
RRO: 104660959(JAK3)
RBB: 108534230(JAK3)
CJC: 100397491(JAK3)
SBQ: 101034707(JAK3)
MMU: 16453(Jak3)
RNO: 25326(Jak3)
CGE: 100773497(Jak3)
NGI: 103726892(Jak3)
HGL: 101715472(Jak3)
CCAN: 109698332(Jak3)
TUP: 102471949(JAK3)
CFA: 610004(JAK3)
AML: 100474005(JAK3)
UMR: 103675167(JAK3)
ORO: 101369142(JAK3)
FCA: 101092339(JAK3)
PTG: 102966280(JAK3)
AJU: 106969157(JAK3)
BTA: 538276(JAK3)
BOM: 102286011(JAK3)
BIU: 109561426(JAK3)
PHD: 102327649(JAK3)
CHX: 102171504(JAK3)
OAS: 101112816(JAK3)
SSC: 100518649(JAK3)
CFR: 102503866(JAK3)
CDK: 105101858(JAK3)
BACU: 103012385(JAK3)
LVE: 103081519(JAK3)
OOR: 101283171(JAK3)
ECB: 100147451(JAK3)
EPZ: 103542314(JAK3) 103542962
EAI: 106830858(JAK3)
MYB: 102241153(JAK3)
MYD: 102767426(JAK3)
HAI: 109382346(JAK3)
RSS: 109450092(JAK3)
PALE: 102898620(JAK3)
LAV: 100665896(JAK3)
TMU: 101345231
MDO: 100010720(JAK3)
SHR: 100920108(JAK3)
OAA: 100085612(JAK3)
GGA: 395845(JAK3)
MGP: 100544996(JAK3)
CJO: 107325427(JAK3)
GFR: 102039894(JAK3)
PHI: 102110608(JAK3)
PMAJ: 107199430
FPG: 101914306(JAK3)
FCH: 102054762(JAK3)
CLV: 102096086(JAK3)
AAM: 106486617(JAK3)
ASN: 102382453(JAK3)
AMJ: 102570658(JAK3) 109286140
PSS: 102443764(JAK3)
CMY: 102943900(JAK3)
CPIC: 101946232(JAK3)
PVT: 110072505(JAK3)
PBI: 103062083(JAK3)
GJA: 107120632(JAK3)
XLA: 378531(jak3.L)
XTR: 100135373(jak3)
NPR: 108790798(JAK3)
SPAR: SPRG_12528
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8022790
  Authors
Kawamura M, McVicar DW, Johnston JA, Blake TB, Chen YQ, Lal BK, Lloyd AR, Kelvin DJ, Staples JE, Ortaldo JR, et al.
  Title
Molecular cloning of L-JAK, a Janus family protein-tyrosine kinase expressed in natural killer cells and activated leukocytes.
  Journal
Proc Natl Acad Sci U S A 91:6374-8 (1994)
DOI:10.1073/pnas.91.14.6374
  Sequence
[hsa:3718]

DBGET integrated database retrieval system