KEGG   ORTHOLOGY: K11219Help
Entry
K11219                      KO                                     
Name
TYK2
Definition
non-receptor tyrosine-protein kinase TYK2 [EC:2.7.10.2]
Pathway
Osteoclast differentiation
Jak-STAT signaling pathway
Toxoplasmosis
Hepatitis C
Measles
Influenza A
Herpes simplex infection
Epstein-Barr virus infection
Disease
H00107  
Other well-defined immunodeficiency syndromes
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04630 Jak-STAT signaling pathway
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
 Organismal Systems
  Development
   04380 Osteoclast differentiation
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
 Human Diseases
  Infectious diseases
   05162 Measles
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
   05164 Influenza A
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
   05160 Hepatitis C
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
   05168 Herpes simplex infection
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
   05169 Epstein-Barr virus infection
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
   05145 Toxoplasmosis
    K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
Protein kinases [BR:ko01001]
 Tyrosine protein kinases
  JAK family
   K11219  TYK2; non-receptor tyrosine-protein kinase TYK2
BRITE hierarchy
Other DBs
GO: 
Genes
HSA: 
7297(TYK2)
PTR: 
455703(TYK2)
PPS: 
100979090(TYK2)
GGO: 
101129051(TYK2)
PON: 
100439493(TYK2)
MCC: 
574130(TYK2)
MMU: 
54721(Tyk2)
RNO: 
100361294(Tyk2)
CFA: 
476714(TYK2)
AML: 
100468422(TYK2)
FCA: 
101090171(TYK2)
BTA: 
512484(TYK2)
SSC: 
397363(TYK2)
MDO: 
100012931(TYK2)
SHR: 
100927743(TYK2)
GGA: 
430113(TYK2)
MGP: 
100542141(TYK2)
XLA: 
444089(tyk2)
XTR: 
100489432
DRE: 
100536675(tyk2)
TRU: 
101080190
OLA: 
101155851
 » show all
TaxonomyKoalaUniProt
Reference
PMID:2216457
  Authors
Firmbach-Kraft I, Byers M, Shows T, Dalla-Favera R, Krolewski JJ
  Title
tyk2, prototype of a novel class of non-receptor tyrosine kinase genes.
  Journal
Oncogene 5:1329-36 (1990)
Reference
PMID:7526154
  Authors
Colamonici O, Yan H, Domanski P, Handa R, Smalley D, Mullersman J, Witte M, Krishnan K, Krolewski J
  Title
Direct binding to and tyrosine phosphorylation of the alpha subunit of the type I interferon receptor by p135tyk2 tyrosine kinase.
  Journal
Mol Cell Biol 14:8133-42 (1994)
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